Building Tissues

Building Tissues

Author: Joseph W. Freeman

Publisher: CRC Press

Published: 2018-11-08

Total Pages: 309

ISBN-13: 0429768737

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Tissue engineering uniquely applies concepts and techniques from biology and engineering in order to heal or produce new tissues after disease or traumatic injury. A successful tissue engineer must have knowledge of cellular biology, cell signaling, extracellular matrix development, and tissue structure and integrate it with the application of stresses and strains, mass transfer, mechanical properties, and heat transfer. In order to train the next generation of successful tissue engineers, this text gives the reader a background in both the engineering and biology associated with tissue engineering. In reading this text, students will learn about these two different areas of study and how they can be integrated with one another to understand tissues in the human body and solve biomedical problems. Students will be introduced to definitions of engineering concepts, the practical use of stress-strain relationships, material strength, mass transfer, and heat transfer. Through examples and problems, students will apply engineering equations to medical and biomedical situations including actual tissue engineering problems. Students will be introduced to a variety of cell and tissue types and be given the background information necessary to apply the use of cells to the growth and development of new tissues. Students will learn how to select the proper material for the replacement of a particular tissue and why it is important to know about the mechanical properties and degradability of a material prior to implantation. Students will learn how the application of force, material selection, and changes in temperature can positively or negatively affect cell behavior and tissue development. Tissue structure will be described and students will learn about the direct relationship between the structure of a tissue and its properties.


Building Tissues

Building Tissues

Author: Joseph W. Freeman

Publisher: CRC Press

Published: 2018-11-08

Total Pages: 215

ISBN-13: 0429768745

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Tissue engineering uniquely applies concepts and techniques from biology and engineering in order to heal or produce new tissues after disease or traumatic injury. A successful tissue engineer must have knowledge of cellular biology, cell signaling, extracellular matrix development, and tissue structure and integrate it with the application of stresses and strains, mass transfer, mechanical properties, and heat transfer. In order to train the next generation of successful tissue engineers, this text gives the reader a background in both the engineering and biology associated with tissue engineering. In reading this text, students will learn about these two different areas of study and how they can be integrated with one another to understand tissues in the human body and solve biomedical problems. Students will be introduced to definitions of engineering concepts, the practical use of stress-strain relationships, material strength, mass transfer, and heat transfer. Through examples and problems, students will apply engineering equations to medical and biomedical situations including actual tissue engineering problems. Students will be introduced to a variety of cell and tissue types and be given the background information necessary to apply the use of cells to the growth and development of new tissues. Students will learn how to select the proper material for the replacement of a particular tissue and why it is important to know about the mechanical properties and degradability of a material prior to implantation. Students will learn how the application of force, material selection, and changes in temperature can positively or negatively affect cell behavior and tissue development. Tissue structure will be described and students will learn about the direct relationship between the structure of a tissue and its properties.


Principles of Tissue Engineering

Principles of Tissue Engineering

Author: Robert Lanza

Publisher: Elsevier

Published: 2000-05-16

Total Pages: 1039

ISBN-13: 008053967X

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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others


Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.


Essentials of 3D Biofabrication and Translation

Essentials of 3D Biofabrication and Translation

Author: Anthony Atala

Publisher: Academic Press

Published: 2015-07-17

Total Pages: 441

ISBN-13: 0128010150

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Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. - Provides a new and versatile method to fabricating living tissue - Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction - Describes current approaches and future challenges for translational science - Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms


Skeletal Tissue Mechanics

Skeletal Tissue Mechanics

Author: R. Bruce Martin

Publisher: Springer

Published: 2015-10-29

Total Pages: 513

ISBN-13: 1493930028

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This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter


Tissue Engineering

Tissue Engineering

Author: Clemens van Blitterswijk

Publisher: Academic Press

Published: 2014-12-10

Total Pages: 891

ISBN-13: 0124202101

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Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface. - Effectively reviews major foundational topics in tissue engineering in a clear and accessible fashion - Includes state of the art experiments presented in break-out boxes, chapter objectives, chapter summaries, and multiple choice questions to aid learning - New edition contains material on regulatory authorities and commercial considerations in tissue engineering