This book is based on a 1981 German language edition published by Springer Verlag, Vienna, under the title Bioprozesstechnik. Philip Manor has done the translation, for which I am deeply grateful. This book differs from the German edition in many ways besides language. It is substantially enlargened and updated, and examples of computer simula tions have been added together with other appendices to make the work both more comprehensive and more practical. This book is the result of over 15 years of experience in teaching and research. It stems from lectures that I began in 1970 at the Technical University of Graz, Austria, and continued at the University of Western Ontario in London, Canada, 1980; at the Free University of Brussels, 1981; at Chalmers Technical University in G6teborg, Sweden; at the Academy of Sciences in lena, East Germany; at the "Haus der Technik" in Essen, West Germany, 1982; at the Academy of Science in Sofia, Bulgaria; and at the Technical University of Delft, Netherlands, 1986. The main goals of this book are, first, to bridge the gap that always exists between basic principles and applied engineering practice, second, to enhance the integration between biological and physical phenomena, and, third, to contribute to the internal development of the field of biotechnology by describing the process-oriented field of bioprocess technology.
Overview of BioprocessingTypes of FermentationStructure and Anatomy of FermenterTypes of FermenterIsolation and Screening of Industrially Important MicrobesMedia for Industrial FermentationProcess Control in FermentationDownstream ProcessingMicrobial Contamination and Spoilage of FoodGeneral Methods of Preserving FoodProduction of Milk ProductsProduction of Bakery ProductsProduction of Fermented BeveragesSingle Cell ProteinsMushroomVaccinesAntibiotic ProductionIndustrial EnzymesImmobilizationEnzyme KineticsOrganic AcidsVitaminsMicrobial PolysaccharidesBiofertilizersBiopesticidesBioremediation and TransformationBiological Waste TreatmentBiogas ProductionBiofuelsEthanolBiodieselGlossaryReferencesIndex
Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies
The ability of the United States to sustain a dominant global position in biotechnology lies in maintaining its primacy in basic life-science research and developing a strong resource base for bioprocess engineering and bioproduct manufacturing. This book examines the status of bioprocessing and biotechnology in the United States; current bioprocess technology, products, and opportunities; and challenges of the future and what must be done to meet those challenges. It gives recommendations for action to provide suitable incentives to establish a national program in bioprocess-engineering research, development, education, and technology transfer.
This book provides an extensive overview of the latest research in environmentally benign integrated bioprocess technology. The cutting edge bioprocess technologies highlighted in the book include bioenergy from lignocellulose materials, biomass gasification, ethanol, butanol, biodiesel from agro waste, enzymatic bioprocess technology, food fermentation with starter cultures, and intellectual property rights for bioprocesses. This book further addresses niche technologies in bioprocesses that broadens readers’ understanding of downstream processing for bio products and membrane technology for bioprocesses. The latest developments in biomass and bioenergy technology are reviewed exhaustively, including IPR rights, nanotechnology for bioenergy products, biomass gasification, and biomass combustion. This is an ideal book for scientists, engineers, students, as well as members of industry and policy-makers. This book also: Addresses cutting-edge technologies in bioprocesses Broadens readers’ understanding of metabolic engineering, downstream processing for bioproducts, and membrane technology for bioprocesses Reviews exhaustively the latest developments in biomass and bioenergy technology, including nanotechnology for bioenergy products, biomass gasification, biomass combustion, and more
In biotechnology, the concept of recovery and product purification is different for different market sectors. Nevertheless there are many underpinning principles that may be applied at all scales of operation. This text describes those principles and their applications. Attention is directed to providing a thorough predominantly from a technology/engineering perspective enabling a greater understanding of the principles of process development.
With the advancement of computers, the use of modeling to reduce time and expense, and improve process optimization, predictive capability, process automation, and control possibilities, is now an integral part of food science and engineering. New technology and ease of use expands the range of techniques that scientists and researchers have at the
This book presents the select peer-reviewed proceedings of the International Conference on Advances in Bioprocess Engineering and Technology (ICABET 2020). The book covers all aspects of bioprocesses, especially related to fermentation technology, food technology, environmental biotechnology, and sustainable energy. Along with this primary theme, the focus is on recent advances in bioprocessing research such as biosensors, micro-reactors, novel separation techniques, bioprocess control, bio-safety, advanced techniques for waste to wealth generation, and nanobiotechnology. This contents are divided according to the major themes of the conference: (i) Fermentation Technology and Bioreactor, (ii) Food Pharmaceuticals and Health care, (iii) Environment and Agriculture, and (iv) Sustainable Energy. This book is intended to help students, researchers, and industry professionals acquire knowledge on innovative technologies and recent advancements in the field of bioprocess engineering and technology.
In the second edition of this bestselling textbook, new materials have been added, including a new chapter on real time polymerase chain reaction (RTPCR) and a chapter on fungal solid state cultivation. There already exist a number of excellent general textbooks on microbiology and biotechnology that deal with the basic principles of microbial biotechnology. To complement them, this book focuses on the various applications of microbial-biotechnological principles. A teaching-based format is adopted, whereby working problems, as well as answers to frequently asked questions, supplement the main text. The book also includes real life examples of how the application of microbial-biotechnological principles has achieved breakthroughs in both research and industrial production.Although written for polytechnic students and undergraduates, the book contains sufficient information to be used as a reference for postgraduate students and lecturers. It may also serve as a resource book for corporate planners, managers and applied research personnel.
The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems.* * First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists* Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems* Comprehensive, single-authored* 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems* 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors* Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading* Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used* Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.
