Biomedical Studies Using Free Electron Laser and Other Laser Systems
Biomedical Studies Using Free Electron Laser and Other Laser Systems

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Published: 1995

Total Pages: 40

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Baylor Research Institute, in collaboration with the Dept. of Biomedical Engineering at U.T. Austin and the Dept. of Laser Science at UT-M.D. Anderson hospital in Houston evaluated potential uses for high peak power pulsed and continuous wave lasers and the free-electron lasers at Duke, Stanford, and Vanderbilt for medical use. Resulting developments for potential medical use include eradication of viruses in blood banking, development of photoproducts for use in treatment of AIDS and cancer, photochemicals for non-thermal tissue welding, devices to augment thermal welding, systems for cartilage repair, combined wavelength lasers for tissue hemostasis and ablation, and a new family of photochemicals for use in tracking tumors and with potential as bonding agents in material science. Basic knowledge of laser-tissue interactions was developed.

Biomedical Studies with the Free Electron Laser
Biomedical Studies with the Free Electron Laser

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Published: 1989

Total Pages: 219

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An electrostatic VandeGraff FEL was used to study the effects of infrared radiation on the synthesis of DNA and RNA in living vertebrate cells in culture. The laser was operated at wavelengths of 165 and 200 microns at power densities of 0.1 - 30 KW/sq.cm. Cells were incubated in radioactive precursors to either DNA or RNA following exposure to the FEL and analyzed by light microscope autoradiography. The results indicated that the 200 micron wavelength inhibited DNA but not RNA synthesis in a subpopulation of cells and the 165 micron wavelength inhibited RNA synthesis and not DNA synthesis. The statistical significance for the 200 micron wavelength studies was p = 0.05 and for the 165 micron wavelength studies p = 0.001 - 0.005. Partial Contents: Delayed Retinal Effects of Frequency Doubled YAG Laser (532 nm); Tumor Destruction in Photodynamic Therapy; Comparison of Continuous Wave Lasers for Endarterectomy of Experimental Atheromas; Mechanism of Tumor Destruction Following Photodynamic Therapy with Hematoporphyrin Derivative, Chlorin, and Phthalocyanine; Phycocyanin; Laser Activation, Cytotoxic Effects, and Uptake in Human Atherosclerotic Plague; Basic Laser Physics and Tissue Interaction; Biological Studies on the Free Electron Laser; Ablation of Bone and Methacrylate by a Prototype Mid-Infrared Erbium; YAG Laser; and Corneal Healing after Excimer Laser Surface Ablation.

Medical/Materials Research and Applications of Free Electron Laser and Related Technologies
Medical/Materials Research and Applications of Free Electron Laser and Related Technologies

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Published: 1991

Total Pages: 18

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To investigate biomedical and materials laser-optical systems that have potential clinical and industrial applications. To develop clinical and industrial applications of Free-Electron laser technology and related broadly wavelength tunable, short pulse, ultrafast, high peak power, high average power laser systems that are efficient, compact, reliable and clinically and commercially practical systems. To carry out actual FEL experiments with collaborators at existing FEL facilities at Duke, Vanderbilt and Stanford Universities.

Biomedical Aspects of the Laser
Biomedical Aspects of the Laser

Author: Leon Goldman

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 241

ISBN-13: 3642857973

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This book is a review of past and current studies and future plans of the Laser Laboratory in Cincinnati and some of the contributions of laser research groups in other medical centers. Special thanks are due to the Directing Physicist of the Laser Labora tory, R. James Rockwell. Without his advice, constant supervision and corrections, this enthusiastic investigator would continue to upset even many more people than he has done already. The excuse, of course, is to stimulate much needed interest and controlled research and development of the laser for biology and medicine. The Associate Research Physicist, Ralph Schooley, has worked with many phases of laser research but especially in Q spoiling, Raman spectroscopy, and the almost alchemy of holography. Holography, as of now, provides many opportunities for Gumperson's Law, "If anything can go wrong, it will. " Sincere appreciation is expressed to the Surgeons in the Laser Labora tory, who have supplied clinical and investigative surgical supervision often under great difficulties, Dr. V. E. Siler and Dr. Bruce Henderson. We are grateful for help from the Directing Biologist of the Laser Labo ratory, Edmond Ritter, the Director of Laser Neurosurgery, Dr. Thomas Brown and the Professor of Neurosurgery, Dr. Robert McLaurin, for important and basic work in laser neurosurgery. Special thanks are given to Robert Meyer, who has given most of the treatments in careful and skillful fashion, and his associate, Robert Otten.

Vanderbilt Free Electron Laser Project in Biomedical and Materials Research
Vanderbilt Free Electron Laser Project in Biomedical and Materials Research

Author: Richard F. Haglund

Publisher:

Published: 1988

Total Pages: 17

ISBN-13:

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The Medical Free Electron Laser Program was awarded to develop, construct and operate a free-electron laser facility dedicated to biomedical and materials studies, with particular emphases on: fundamental studies of absorption and localization of electromagnetic energy on and near material surfaces, especially through electronic and other selective, non-statistical processes; non-thermal photon-materials interactions (e.g., electronic bond-breaking or vibrational energy transfer) in physical and biological materials as well as in long-wavelength biopolymer dynamics; development of FEL-based methods to study drug action and to characterize biomolecular properties and metabolic processes in biomembranes; clinical applications in otolaryngology, neurosurgery, ophthalmology and radiology stressing the use of the laser for selective laser-tissue, laser-cellular and laser-molecule interactions in both therapeutic and diagnostic modalities.

The Biomedical Laser
The Biomedical Laser

Author: Leon Goldman

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 341

ISBN-13: 1461259223

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The laser's range of application is extraordinary. Arthur Schawlow says, "What instrument can shuck a bucket of oysters, correct typing errors, fuse atoms, lay a straight line for a garden bed, repair detached retinas, and drill holes in dia monds?"O The laser's specifically biomedical uses cover a similarly broad and interesting spectrum. In this book, I have endeavored to convey some of the fas cination that the laser has long held for me. It is my hope that both clinicians and researchers in the various medical and surgical specialties will find the book a use ful introduction. Biologists, particularly molecular biologists, should also find a great deal of relevant information herein. This volume's distinguished contributors provide admirably lucid discussions of laser principles, instrumentation, and current practice in their respective special ties. Safety, design, capabilities, and costs of various lasers are also reviewed. We have aimed to create a practical text that is comprehensive but not exhaustive. Our emphasis on the practical, rather than the esoteric, is dictated not only by the short history of biomedical laser use, but by the extent of the community to which this information will appeal.

Research to Develop Biomedical Applications of Free Electron Laser Technology
Research to Develop Biomedical Applications of Free Electron Laser Technology

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Published: 2004

Total Pages: 0

ISBN-13:

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Specific Aim 1: Develop and test plaque characterization criteria based on bireftingence. Coronary artenes were obtained at autopsy and imaged with the existing OCT system in our laboratory. The specimens were opened and imaged at normal body temperature (37-C) in saline. To ensure proper registration of OCT images with histolog the image location was marked with ink viewable on the OCT image and in the histology section. Routine histologic processing was performed using H & E, Elastic and Movat's pentachrome stains. Trichrome was used for fibrous tissue identification. Individual images were oriented and scaled to match histology. In the OCT images, the axial periodicity of the birefringence banding was measured using image processing software. A set of 20 correlated OCT and histology pairs were used to identify characterization criteria basal on birefringence. Our results indicated that fibrous plaque provides a strong birefringence as measured by OCT while lipid rich and calcific plaques can be identified by a complete loss of birefringenee.

Laser-Tissue Interactions
Laser-Tissue Interactions

Author: Markolf H. Niemz

Publisher: Springer

Published: 2007-08-15

Total Pages: 316

ISBN-13: 3540721924

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Medical practitioners, scientists and graduate students alike will find this exhaustive survey a vital learning tool. It provides a thorough description of the fundamentals and applications in the field of laser-tissue interactions. Basic concepts such as the optical and thermal properties of tissue, the various types of tissue ablation, and optical breakdown and its related effects are treated in detail. The author pays special attention to mathematical tools (Monte Carlo simulations, the Kubelka-Munk theory etc.) and approved techniques (photodynamic therapy, laser-induced interstitial thermotherapy etc.). A section on applications reviews clinically relevant methods in modern medicine using the latest references.

Laser-Tissue Interactions
Laser-Tissue Interactions

Author: Markolf Niemz

Publisher: Springer Science & Business Media

Published: 2013-03-14

Total Pages: 303

ISBN-13: 3662031930

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Laser--Tissue Interactions provides a thorough description of the fundamentals and applications in this field. Basic conceptions such as optical and thermal properties of tissue, various types of tissue ablation, and optical breakdown with related effects are treated in detail. Special attention is given to mathematical tools (Monte Carlo simulations, Kubelka--Munk theory) and approved techniques (photodynamic therapy, laser-induced interstitial thermotherapy). The part on applications reviews clinically relevant methods in modern medicine according to the latest references. The last chapter includes today's standards of laser safety, with a careful selection of essential guidelines published