Biomarkers and Clinical Indicators in Motor Neuron Disease
Author: Pierre-Francois Pradat
Publisher: Frontiers Media SA
Published: 2020-01-24
Total Pages: 393
ISBN-13: 2889634159
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Motor Neuron Disease Research Progress
Author: Raffaele L. Mancini
Publisher: Nova Publishers
Published: 2008
Total Pages: 330
ISBN-13: 9781604561555
DOWNLOAD EBOOKThe motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neurons control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region. Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech. This new book presents the latest research from around the globe.
Toward More Efficient Clinical Trials in Motor Neuron Disease - Total Drug Exposure Analysis and Bulbar Biomarker Development
Author: Haruhiko Banno
Publisher:
Published: 2016
Total Pages:
ISBN-13:
DOWNLOAD EBOOKIn my first article, we used a database of the clinical trial of ceftriaxone. Ceftriaxone, a [beta]-lactam antibiotic, has been shown to increase the glutamate transporter that clears glutamate from the synapse. In the clinical trial of ceftriaxone for ALS, 514 participants in the United States and Canada were enrolled. The trial did not show significant clinical efficacy; however, treatment adherence may have masked potential efficacy. We found total ceftriaxone exposure analysis did not show overall efficacy of ceftriaxone. We concluded that failed clinical trials with intervention adherence problems may need total drug exposure analysis to assess potential effect of the medication.
Challenges and Opportunities in Industrial and Mechanical Engineering: A Progressive Research Outlook
Author: S M Pandey
Publisher: CRC Press
Published: 2024-06-24
Total Pages: 1036
ISBN-13: 1040002315
DOWNLOAD EBOOKPresent time Industry 4.0 is the need of all industries because it connects industries to AI, high productivity, safety, and flexibility, ensures the 100% utilization of resources across diverse manufacturing systems, and could accelerate normal manufacturing systems to advanced manufacturing systems by using robotics, additive manufacturing, and many more. In this book, the collection of selected papers is constituted from the International Conference on Progressive Research in Industrial & Mechanical Engineering (PRIME 2021), which was at the National Institute of Technology (NIT), Patna, India from August 5 to 7, 2021. This conference brings together all academic people, industry experts, and researchers from India as well as abroad for involving thoughts on the needs, challenges, new technology, opportunities threats in the current transformational field of aspire. This book deliberates on several elements and their relevance to hard-core areas of industrial and mechanical engineering including design engineering, production engineering, indus trial engineering, automobile engineering, thermal and fluid engineering, mechatronics control robotics, interdisciplinary, and many new emerging topics that keep potential in several areas of applications. This book focuses on providing versatile knowledge of cut ting-edge practices to all readers, helping to develop a clear vision toward Industry 4.0, robotics automation, and additive manufacturing in this demanding and evolving time. The book will be a treasured reference for students, researchers, and professionals inter ested in mechanical engineering and allied fields.
Motor Neuron Disease in Adults
Author: Mark B. Bromberg
Publisher: Contemporary Neurology
Published: 2014-10-28
Total Pages: 369
ISBN-13: 019978311X
DOWNLOAD EBOOK'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.
Neurodegenerative Disorders
Author: Orla Hardiman
Publisher: Springer
Published: 2016-02-26
Total Pages: 336
ISBN-13: 3319233092
DOWNLOAD EBOOKThis new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.
Motor Neurone Disease
Author:
Publisher: Elsevier
Published: 2024-05-31
Total Pages: 550
ISBN-13: 0443141177
DOWNLOAD EBOOKInternational Review in Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology series Updated release includes the latest information on Motor Neuron Disease
Monitoring Metabolic Status
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2004-08-29
Total Pages: 469
ISBN-13: 0309091594
DOWNLOAD EBOOKThe U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.
Data Mining for Biomedical Applications
Author: Jinyan Li
Publisher: Springer
Published: 2006-02-28
Total Pages: 163
ISBN-13: 3540331050
DOWNLOAD EBOOKThis book constitutes the refereed proceedings of the International Workshop on Data Mining for Biomedical Applications, BioDM 2006, held in Singapore in conjunction with the 10th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006). The 14 revised full papers presented together with one keynote talk were carefully reviewed and selected from 35 submissions. The papers are organized in topical sections
The Management of Motor Neurone Disease
Author: George M. Cochrane
Publisher:
Published: 1987
Total Pages: 124
ISBN-13:
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