Biodefense in the Age of Synthetic Biology
Biodefense in the Age of Synthetic Biology

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2019-01-05

Total Pages: 189

ISBN-13: 0309465184

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Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Breeding Bio Insecurity
Breeding Bio Insecurity

Author: Lynn C. Klotz

Publisher: University of Chicago Press

Published: 2009-10-15

Total Pages: 269

ISBN-13: 0226444074

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In the years since the 9/11 attacks—and the subsequent lethal anthrax letters—the United States has spent billions of dollars on measures to defend the population against the threat of biological weapons. But as Lynn C. Klotz and Edward J. Sylvester argue forcefully in Breeding Bio Insecurity, all that money and effort hasn’t made us any safer—in fact, it has made us more vulnerable. Breeding Bio Insecurity reveals the mistakes made to this point and lays out the necessary steps to set us on the path toward true biosecurity. The fundamental problem with the current approach, according to the authors, is the danger caused by the sheer size and secrecy of our biodefense effort. Thousands of scientists spread throughout hundreds of locations are now working with lethal bioweapons agents—but their inability to make their work public causes suspicion among our enemies and allies alike, even as the enormous number of laboratories greatly multiplies the inherent risk of deadly accidents or theft. Meanwhile, vital public health needs go unmet because of this new biodefense focus. True biosecurity, the authors argue, will require a multipronged effort based in an understanding of the complexity of the issue, guided by scientific ethics, and watched over by a vigilant citizenry attentive to the difference between fear mongering and true analysis of risk. An impassioned warning that never loses sight of political and scientific reality, Breeding Bio Insecurity is a crucial first step toward meeting the evolving threats of the twenty-first century.

Applied Biosecurity: Global Health, Biodefense, and Developing Technologies
Applied Biosecurity: Global Health, Biodefense, and Developing Technologies

Author: Ryan N. Burnette

Publisher: Springer Nature

Published: 2021-05-31

Total Pages: 170

ISBN-13: 303069464X

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This book describes an adaptable biothreat assessment process to complement overall biorisk management programs, incorporating threat management and the unique natures of biological assets. Further, this book examines the nexus between public health, international security, and developing technologies, building a case for augmenting biosecurity to levels beyond the laboratory constraints. With the face of biological and biomedical sciences changing, this book describes how with proper biosecurity development, these can become assets, rather than liabilities, to secure our world from natural and man-made biological disasters. The world is changing rapidly with respect to developing threats, such as terrorism, and dual-use technologies, such as synthetic biology, that are challenging how we think about biosafety and biosecurity. Further, the fields of public health and international security are colliding, as both of these share the common enemy: intentional or natural biological incidents. To date, biosecurity has been limited to laboratory-level application, and complicating efforts, and lacks credentialed biosecurity professionals skilled in both the biological sciences and threat management techniques. The result is a fragmented field of practice, with tremendous need, from the lab to the outbreak. Underpinning these principles is the SARS-CoV-2 coronavirus pandemic, providing a historic milestone to examine biosecurity through a global lens. This book describes biosecurity as a set of practices and principles to be augmented out of the constrained laboratory environment, and applied to larger efforts, such as international threat reduction and biological incident management.

American Biodefense
American Biodefense

Author: Frank L. Smith III

Publisher: Cornell University Press

Published: 2014-09-19

Total Pages: 205

ISBN-13: 0801455154

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Biological weapons have threatened U.S. national security since at least World War II. Historically, however, the U.S. military has neglected research, development, acquisition, and doctrine for biodefense. Following September 11 and the anthrax letters of 2001, the United States started spending billions of dollars per year on medical countermeasures and biological detection systems. But most of this funding now comes from the Department of Health and Human Services rather than the Department of Defense. Why has the U.S. military neglected biodefense and allowed civilian organizations to take the lead in defending the country against biological attacks? In American Biodefense, Frank L. Smith III addresses this puzzling and largely untold story about science, technology, and national security.Smith argues that organizational frames and stereotypes have caused both military neglect and the rise of civilian biodefense. In the armed services, influential ideas about kinetic warfare have undermined defense against biological warfare. The influence of these ideas on science and technology challenges the conventional wisdom that national security policy is driven by threats or bureaucratic interests. Given the ideas at work inside the U.S. military, Smith explains how the lessons learned from biodefense can help solve other important problems that range from radiation weapons to cyber attacks.

Biosecurity and Bioterrorism
Biosecurity and Bioterrorism

Author: Jeffrey Ryan

Publisher: Butterworth-Heinemann

Published: 2016-02-18

Total Pages: 394

ISBN-13: 0128020571

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Biosecurity and Bioterrorism, Second Edition, takes a holistic approach to biosecurity, with coverage of pathogens, prevention, and response methodology. It addresses these hazards in the context of vulnerability assessments and the planning strategies government and industry can use to prepare for and respond to such events. The book is organized into four thematic sections: Part I provides a conceptual understanding of biowarfare, bioterrorism and the laws we have to counteract this; Part II investigates known bioagents and the threat from emerging diseases; Part III focuses on agricultural terrorism and food security; and Part IV outlines international, US, and local initiatives for biodefense and biosecurity. Case studies illustrate biodefense against both intentional terrorism and natural outbreaks. - Covers emerging threats of pandemic influenza, antibiotic resistant strains of bacterial pathogens, and severe respiratory diseases caused by novel viruses - Offers increased international coverage, including initiatives to counter biological weapons and threats, and food security - Updated throughout with latest protocols for dealing with biological threats and new case studies - Includes online instructor ancillaries - PowerPoint lecture slides, test questions, and an instructor manual, for increased classroom functionality

Handbook on Biological Warfare Preparedness
Handbook on Biological Warfare Preparedness

Author: S.J.S. Flora

Publisher: Academic Press

Published: 2019-10-05

Total Pages: 308

ISBN-13: 012812055X

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Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. - Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins - Discusses medical countermeasures, including vaccines and post-exposure therapeutics - Includes a comprehensive review of current methods of detection

Giving Full Measure to Countermeasures
Giving Full Measure to Countermeasures

Author: National Research Council

Publisher: National Academies Press

Published: 2004-04-06

Total Pages: 160

ISBN-13: 0309166519

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In recent years, substantial efforts have been initiated to develop new drugs, vaccines, and other medical interventions against biological agents that could be used in bioterrorist attacks against civilian populations. According to a new congressionally mandated report from the Institute of Medicine and National Research Council of the National Academies, to successfully develop these drugs, vaccines, and other medical interventions against biowarfare agents, Congress should authorize the creation of a new agency within the Office of the Secretary of the U.S. Department of Defense. The committee recommended that Congress should improve liability protections for those who develop and manufacture these products, to stimulate willingness to invest in new research and development for biowarfare protection. Giving Full Measure to Countermeasures also identifies other challengesâ€"such as the need for appropriate animal models and laboratories equipped with high-level biosafety protectionsâ€"that will require attention if DoD efforts to develop new medical countermeasures are to be successful.

Biodefense
Biodefense

Author: Michael S. Bronze

Publisher: Taylor & Francis

Published: 2005

Total Pages: 838

ISBN-13: 9781904933120

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The anthrax attacks by bioterrorists in the USA in October 2001 served to highlight our vulnerability to biological warfare and to act as an impetus for a massive increase in funding for biodefense research. In this timely book, top biodefense experts critically review every aspect of this complex issue. The microbiology, diagnosis, pathogenesis, epidemiology, infection control and novel therapeutics for all the key pathogens involved are comprehensively covered. Biodefense is currently focused on anthrax, smallpox, plague, tularemia, botulism and viral hemorrhagic fevers and entire chapters are devoted to each of these topics. Further chapters cover the bioterrorism threat from other diseases including brucellosis, glanders, melioidosis, psittacosis, Q fever, typhoid, gastroenteritis and cryptosporidiosis. Biological toxins derived from living organisms, such as the epsilon toxin derived from Clostridium perfringens, mycotoxins and plant-derived toxins such as ricin are also reviewed in detail. Two fascinating chapters are devoted to agroterrorism, the use of infectious agents that target animals and plants to decimate the food supply. Additional chapters cover emerging pathogens and novel bio-engineered agents that could be used in bioterrorism. The book also covers hospital preparedness, infection control, psychosocial issues, and the evolving methods for surveillance and detection in biodefence.

Bio-Imperialism
Bio-Imperialism

Author: Gwen Shuni D'Arcangelis

Publisher: Rutgers University Press

Published: 2020-12-18

Total Pages: 117

ISBN-13: 1978815166

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Bio-Imperialism focuses on an understudied dimension of the war on terror: the fight against bioterrorism. This component of the war enlisted the biosciences and public health fields to build up the U.S. biodefense industry and U.S. global disease control. The book argues that U.S. imperial ambitions drove these shifts in focus, aided by gendered and racialized discourses on terrorism, disease, and science. These narratives helped rationalize American research expansion into dangerous germs and bioweapons in the name of biodefense and bolstered the U.S. rationale for increased interference in the disease control decisions of Global South nations. Bio-Imperialism is a sobering look at how the war on terror impacted the world in ways that we are only just starting to grapple with.

Biodefense Research Methodology and Animal Models, Second Edition
Biodefense Research Methodology and Animal Models, Second Edition

Author: James R. Swearengen

Publisher: CRC Press

Published: 2012-02-16

Total Pages: 427

ISBN-13: 1439836329

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Significant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA’s Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, Biodefense Research Methodology and Animal Models, Second Edition spans the spectrum of coverage from basic research to advanced development of medical countermeasures. Topics discussed in this volume include: A history of biological agents as weapons, from the use of corpses to contaminate water supplies to modern day anthrax attacks Concepts and strategies involved in biowarfare and bioterrorism The development, validation, and importance of animal models in biodefense research Infectious disease aerobiology Studies involving anthrax, glanders, plague, tularemia, Q fever, alphaviruses, orthopoxviruses, and a new chapter on brucellosis Animal models for viral hemorrhagic fevers Botulinum and Ricin toxins Staphylococcal and streptococcal superantigens As the scientific community works diligently to protect the world’s population from the misuse of infectious organisms and toxins, it is imperative that researchers stay abreast of the latest techniques for biodefense research. Exploring in vivo and in vitro assays, this volume brings researchers up to date on the latest information on bacterial and viral infectious agents and biological toxins considered to pose the greatest threats to public safety. In addition, the contributors take a step toward minimizing the use of animals in further experiments by presenting documented findings that can be built upon.