Bioassays in Experimental and Preclinical Pharmacology
Bioassays in Experimental and Preclinical Pharmacology

Author: Karuppusamy Arunachalam

Publisher:

Published: 2021

Total Pages: 271

ISBN-13: 9781071612330

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This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Bioassay Techniques for Drug Development
Bioassay Techniques for Drug Development

Author: Atta-ur-Rahman

Publisher: CRC Press

Published: 2001-10-04

Total Pages: 214

ISBN-13: 1135287228

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The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2014-02-06

Total Pages: 107

ISBN-13: 0309292492

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Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Principles of Safety Pharmacology
Principles of Safety Pharmacology

Author: Michael K. Pugsley

Publisher: Springer

Published: 2015-06-19

Total Pages: 477

ISBN-13: 366246943X

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This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

Drug Discovery and Evaluation
Drug Discovery and Evaluation

Author: Hans G. Vogel

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 790

ISBN-13: 366203333X

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This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Textbook of Pharmacology-II (As per PCI regulations and for medical students)
Textbook of Pharmacology-II (As per PCI regulations and for medical students)

Author: Prof. Prasad Neerati

Publisher: Shashwat Publication

Published: 2024-11-04

Total Pages: 439

ISBN-13: 9360871370

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Pharmacology is the study of how drugs interact with biological systems, playing a pivotal role in understanding disease mechanisms and treatment. The content is designed to guide students, healthcare professionals, and researchers through more complex therapeutic classes, drug interactions, and the evolving landscape of pharmacological research. In this book, we explore the pharmacodynamics and pharmacokinetics of various drug classes, as well as their clinical applications and adverse effects. Additionally, we address recent advances in molecular pharmacology, including personalized medicine and the role of biotechnology in drug development. By integrating case studies and real-world examples, we aim to enhance practical understanding and foster critical thinking in applying pharmacological principles to clinical practice. We would like to express our gratitude to the contributors, researchers, and healthcare professionals whose insights and efforts have enriched the content of this volume. This edition also reflects feedback from students and educators, ensuring that the material remains both relevant and accessible. We hope that Pharmacology II serves as a comprehensive resource for mastering advanced pharmacological concepts and equips readers with the knowledge and skills necessary to excel in the dynamic and ever-changing field of pharmacology.

Textbook of Pharmacology-II
Textbook of Pharmacology-II

Author: Dr. Ravindra Chandrakant Sutar, Ms. Krishna Vag , Dr. Anand Mundada , Ms. Varsha Nadkar , Dr. Anant S. Deshpande

Publisher: Shashwat Publication

Published: 2024-09-23

Total Pages: 406

ISBN-13: 9360878669

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The titled book, “Textbook of Pharmacology II” (As per PCI regulation). The idea of book originated by authors to convey a combined database for easy understanding of Pharmacology. The major aim to write this textbook is to provide information in articulate summarized manner to accomplish necessities of undergraduates as per PCI regulation. This volume is designed not only according to curriculum of undergraduate courses in pharmacy by PCI but also to communicate knowledge on Phamacology for post graduate learners. We assured this book will be originated very valuable by graduates, post graduates, professors and industrial learners.

How Tobacco Smoke Causes Disease
How Tobacco Smoke Causes Disease

Author: United States. Public Health Service. Office of the Surgeon General

Publisher:

Published: 2010

Total Pages: 728

ISBN-13:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.