Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 150 children and their families. Unfortunately, there is little understanding of the causes of ASD, and, despite their broad societal impact, many people believe that the overall research program for autism is incomplete, particularly as it relates to the role of environmental factors. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders, in response to a request from the U.S. Secretary of Health and Human Services, hosted a workshop called "Autism and the Environment: Challenges and Opportunities for Research." The focus was on improving the understanding of the ways in which environmental factors such as chemicals, infectious agents, or physiological or psychological stress can affect the development of the brain. Autism and the Environment documents the concerted effort which brought together the key public and private stakeholders to discuss potential ways to improve the understanding of the ways that environmental factors may affect ASD. The presentations and discussions from the workshop that are described in this book identify a number of promising directions for research on the possible role of different environmental agents in the etiology of autism.
Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.
The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives.
All-new clinical resource for managing children with developmental and behavioral concerns. Developed by leading experts in developmental and behavioral pediatrics, the all-new AAP Developmental and Behavioral Pediatrics gives one place to turn for expert recommendations to deliver, coordinate, and/or monitor quality developmental/behavioral care within the medical home. The one resource with all the essentials for pediatric primary care providers. Evaluation and care initiation: Interviewing and counseling, Surveillance and screening, Psychoeducational testing, Neurodevelopment.
This is a major international textbook for psychiatrists and other professionals working in the field of mental healthcare. With contributions from opinion-leaders from around the globe, this book will appeal to those in training as well as to those further along the career path seeking a comprehensive and up-to-date overview of effective clinical practice backed by research evidence. The book is divided into cohesive sections moving from coverage of the tools and skills of the trade, through descriptions of the major psychiatric disorders and on to consider special topics and issues surrounding service organization. The final important section provides a comprehensive review of treatments covering all of the major modalities. Previously established as the Essentials of Postgraduate Psychiatry, this new and completely revised edition is the only book to provide this depth and breadth of coverage in an accessible, yet authoritative manner.
The Neuropsychology of Autism provides an up-to-date summary on the neuropsychology of autism spectrum disorders (ASD), written by leaders in the field. It summarizes current knowledge about neurochemistry, neuroanatomy, genetics, and clinical presentations and provides helpful discussions on key functions such as language, memory, attention, executive functions, social cognition, motor and sensory functioning.
First published in 1993. Aexithymia is the single most common cause of poor outcome or outright failure of psychoanalysis and psychoanalytic psychotherapy. The reason that this problem has escaped recognition for so long is part of the mystique and paradox of emotions. Affects are familiar to everyone. They are part of our experiences, so ordinary and common that they are equated with being human. The first part of this book is devoted to those mysterious and much studied experiences: emotions. The second part of the book concerns psychic trauma. Certain aspects of these two subjects have to be established in order to give us a broad enough view to approach the third subject: alexithymia.
In this book a group of international experts guide the reader through the clinical features of adults with autism spectrum disorders, describe the care needs of patients and their families, explain the evolution of the disorders into old age, and highlight what can be done to help. Detailed attention is paid to the medical and psychiatric problems of adults with these disorders and the approach to their education and professional integration. In addition, expert neuroscientists summarize current views on the neurobiology of autism. Autism spectrum disorders are devastating neurodevelopmental disorders. Although diagnosis and therapeutic interventions usually take place in infancy, they are chronic lifelong conditions. Surprisingly, the literature on autism spectrum disorders in adults is scarce. Moreover, most mental health professionals working with adults have little training in autism, and adult mental health services around the world are rarely prepared to address the needs of these patients, which tend to increase with age. This book therefore fills a crucial gap in the literature and will prove useful for all who care for and deal with adults in the Autistic Spectrum.
Respiration is an area of the medical study that undergoes fast developments. A better understanding of the neural and cellular mechanisms underlying respiratory disorders and lung function is essential for the evidence-based pharmacotherapy and for optimizing the patient care and prophylactic measures to improve the health and quality of life. This comprehensive book is a blend of basic and clinical research. The book is thought to promote the translation of science into clinical practice. The book presents an update on the areas of current research and clinical interest in the neurobiology of the respiratory system. Recent innovations in detection and management of respiratory diseases are described. The book will be a base of reference in the field of respiration for years to come and a source of future research ideas. This book is a required text for respiratory scientists, neuropathologists, and for clinicians searching for ‘bench to bedside’ treatments of lung diseases.