The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
This book constitutes the refereed proceedings of the Third International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2006, held in federation with the Second International Conference on Natural Computation ICNC 2006. The book presents 115 revised full papers and 50 revised short papers. Coverage includes neural computation, quantum computation, evolutionary computation, DNA computation, fuzzy computation, granular computation, artificial life, innovative applications to knowledge discovery, finance, operations research, and more.
This book combines the advantages of high-dimensional data visualization and machine learning in the context of identifying complex n-D data patterns. It vastly expands the class of reversible lossless 2-D and 3-D visualization methods, which preserve the n-D information. This class of visual representations, called the General Lines Coordinates (GLCs), is accompanied by a set of algorithms for n-D data classification, clustering, dimension reduction, and Pareto optimization. The mathematical and theoretical analyses and methodology of GLC are included, and the usefulness of this new approach is demonstrated in multiple case studies. These include the Challenger disaster, world hunger data, health monitoring, image processing, text classification, market forecasts for a currency exchange rate, computer-aided medical diagnostics, and others. As such, the book offers a unique resource for students, researchers, and practitioners in the emerging field of Data Science.
This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. - Profiles paraneoplastic diseases by tumor type - Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis - Presents individual syndromes of the CNS, PNS, NMJ, and muscle - Investigates the role of antibody markers - Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities - Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS - Reviews therapeutic strategies and clinical approach to PNS patients
The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics
Infectious diseases are the leading cause of death worldwide. In The War Within Us, well-known author and infectious disease specialist Cedric Mims makes the intricacies of the immune system and infectious diseases less baffling for the general reader and answers the questions of how things work and why. The story is told in terms of the ancient conflict between the invader (the infectious disease) and the defender (the body's immune system) and the strategies and counter-strategies used by both sides, making it a book that is both informative and interesting to read. The War Within Us is an ideal introduction to the basics of immunity and infection for general readers and students. It also serves as a quick reference book for physicians, researchers, and other health workers. - Parasite versus host - The conflict: how we defend ourselves - The microbe's response to our defence - How microbes cause diseas - Thumbnail sketches of seven selected diseases: - The threat of new diseases
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
