Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
"Violence against women undermines women's core fundamental rights such as dignity, access to justice and gender equality. For example, one in three women has experienced physical and/or sexual violence since the age of 15; one in five women has experienced stalking; every second woman has been confronted with one or more forms of sexual harassment. What emerges is a picture of extensive abuse that affects many women's lives but is systematically underreported to the authorities. The scale of violence against women is therefore not reflected by official data. This FRA survey is the first of its kind on violence against women across the 28 Member States of the European Union (EU). It is based on interviews with 42,000 women across the EU, who were asked about their experiences of physical, sexual and psychological violence, including incidents of intimate partner violence ('domestic violence'). The survey also included questions on stalking, sexual harassment, and the role played by new technologies in women's experiences of abuse. In addition, it asked about their experiences of violence in childhood. Based on the detailed findings, FRA suggests courses of action in different areas that are touched by violence against women and go beyond the narrow confines of criminal law, ranging from employment and health to the medium of new technologies."--Editor.
Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.
Comprehensively examining the relationship between cognition and emotion, this authoritative handbook brings together leading investigators from multiple psychological subdisciplines. Biological underpinnings of the cognition-emotion interface are reviewed, including the role of neurotransmitters and hormones. Contributors explore how key cognitive processes -- such as attention, learning, and memory -- shape emotional phenomena, and vice versa. Individual differences in areas where cognition and emotion interact -- such as agreeableness and emotional intelligence -- are addressed. The volume also analyzes the roles of cognition and emotion in anxiety, depression, borderline personality disorder, and other psychological disorders.
Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.
This eight-volume encyclopedia brings together a comprehensive collection of work highlighting established research and emerging science in all relevant disciplines in gerontology and population aging. It covers the breadth of the field, gives readers access to all major sub-fields, and illustrates their interconnectedness with other disciplines. With more than 1300 cross-disciplinary contributors—including anthropologists, biologists, economists, psychiatrists, public policy experts, sociologists, and others—the encyclopedia delves deep into key areas of gerontology and population aging such as ageism, biodemography, disablement, longevity, long-term care, and much more. Paying careful attention to empirical research and literature from around the globe, the encyclopedia is of interest to a wide audience that includes researchers, teachers and students, policy makers, (non)governmental agencies, public health practitioners, business planners, and many other individuals and organizations.
This book presents the outcomes of the International Conference on Intelligent Manufacturing and Automation (ICIMA 2018) organized by the Departments of Mechanical Engineering and Production Engineering at Dwarkadas J. Sanghvi College of Engineering, Mumbai, and the Indian Society of Manufacturing Engineers. It includes original research and the latest advances in the field, focusing on automation, mechatronics and robotics; CAD/CAM/CAE/CIM/FMS in manufacturing; product design and development; DFM/DFA/FMEA; MEMS and Nanotechnology; rapid prototyping; computational techniques; industrial engineering; manufacturing process management; modelling and optimization techniques; CRM, MRP and ERP; green, lean, agile and sustainable manufacturing; logistics and supply chain management; quality assurance and environment protection; advanced material processing and characterization; and composite and smart materials.
Recent years have witnessed a revival of research in the interplay between cognition and emotion. The reasons for this renaissance are many and varied. In the first place, emotion theorists have come to recognize the pivotal role of cognitive factors in virtually all aspects of the emotion process, and to rely on basic cognitive factors and insight in creating new models of affective space. Also, the successful application of cognitive therapies to affective disorders has prompted clinical psychologists to work towards a clearer understanding of the connections between cognitive processes and emotional problems. And whereas the cognitive revolutionaries of the 1960s regarded emotions with suspicion, viewing them as nagging sources of "hot" noise in an otherwise cool, rational, and computer-like system of information processing, cognitive researchers of the 1990s regard emotions with respect, owing to their potent and predictable effects on tasks as diverse as object perception, episodic recall, and risk assessment. These intersecting lines of interest have made cognition and emotion one of the most active and rapidly developing areas within psychological science. Written in debate format, this book covers developing fields such as social cognition, as well as classic areas such as memory, learning, perception and categorization. The links between emotion and memory, learning, perception, categorization, social judgements, and behavior are addressed. Contributors come from the U.S., Canada, Australia, and France.
This book is a selection of the most relevant contributions to the LCM 2011 conference in Berlin. The material explores scientific and practical solutions to incorporating life cycle approaches into strategic and operational decision making. There are several sections addressing methodological topics such as LCSM approaches, methods and tools, while more application-oriented sections deal with the implementation of these approaches in relevant industrial sectors including agriculture and food, packaging, energy, electronics and ICT, and mobility.
This book highlights fundamental research on the design and application of engineering materials, and predominantly mechanical engineering applications. This area includes a wide range of technologies and materials, including metals, polymers, composites, and ceramics. Advanced applications include manufacturing cutting-edge materials, testing methods, and multi-scale experimental and computational aspects. The book introduces readers to a wealth of engineering applications in transport, civil, packaging and power generation.
