Androgen Deficiency and Testosterone Replacement
Androgen Deficiency and Testosterone Replacement

Author: Wayne J.G. Hellstrom

Publisher: Springer Science & Business Media

Published: 2012-11-28

Total Pages: 159

ISBN-13: 1627031790

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Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement. Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages.

Testosterone and Aging
Testosterone and Aging

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2004-03-12

Total Pages: 239

ISBN-13: 0309090636

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Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an "antiaging tonic," testosterone's reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.

Testosterone
Testosterone

Author: Susan Nieschlag

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 296

ISBN-13: 3662008149

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New developments in testosterone therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in fourteen chapters. The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Three chapters deal with specific aspects of testosterone action, namely its role in spermatogenesis, its psychotropic effects and its effects on bones. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. Causes and symptoms of male hypogonadism, the major indication for testosterone treatment, are described. Five chapters are devoted to the pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations. The new transdermal testosterone application is described in detail. Side effects of testosterone treatment are reviewed. The possible role of androgens in the development of prostatic hypertrophy and carcinoma is discussed extensively since this question is of major concern to the clinician.

Testosterone Deficiency in Men
Testosterone Deficiency in Men

Author: Hugh Jones

Publisher: Oxford University Press, USA

Published: 2008-09-25

Total Pages: 179

ISBN-13: 0199545138

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This book provides a background of essential knowledge on testosterone deficiency in men, including diagnosis and treatment. It also explores the associations of testosterone deficiency with organ systems and their diseases e.g diabetes, osteoporosis.

Fertility Preservation in Male Cancer Patients
Fertility Preservation in Male Cancer Patients

Author: John P. Mulhall

Publisher: Cambridge University Press

Published: 2013-02-21

Total Pages: 365

ISBN-13: 1107012120

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Written by international authorities, this book is aimed at clinicians dealing with male patients rendered infertile by cancer therapy.

Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Author: Franck Mauvais-Jarvis

Publisher: Springer

Published: 2017-12-08

Total Pages: 630

ISBN-13: 3319701789

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The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Androgens and the Aging Male
Androgens and the Aging Male

Author: B.J. Oddens

Publisher: CRC Press

Published: 1996-11-15

Total Pages: 266

ISBN-13: 9781850707639

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While menopause in women is a well-established and well documented phenomenon, the andropause in men is a relatively new concept. The terms male menopauseand andropausesuggest that this is an abrupt phenomenon related to a sudden deprivation of sex hormones. Unlike the menopause, which has a relatively sudden onset, the andropause appears to be a gradual process. It has been hypothesized that an androgen deficiency might develop with aging. Androgens and the Aging Male explores this hypothesis. The book focuses on the gradually progressive problems related to the decline in androgens that can occur with advancement of age. It examines the debate about the extent to which an age-dependent decline in androgens leads to health problems that affect or impair the quality of life, and the theory behind it. In addition, it reviews studies evaluating the effects of androgen supplementation. Androgens and the Aging Male comprehensively covers androgen function and how it changes over time.

Testosterone
Testosterone

Author: Alexandre Hohl

Publisher: Springer Nature

Published: 2023

Total Pages: 515

ISBN-13: 3031315014

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Even though research on testosterone is increasing, there is still much controversy regarding its physiology and clinical use. This book provides a broad overview on testosterone, from its basic features to the most recent evidence of clinical applicability. In addition, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. The testes are vital organs for reproduction of the human species, besides being the main source of testosterone production in men. Although not essential for survival, these singular structures represent the essence of male biological function. Testosterone is the most important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Also, there is increasing evidence that serum testosterone is a major biomarker status of men's health in general. Hypogonadism in a male refers to a decrease in one or both of the two major functions of the testes: sperm production or testosterone production. These abnormalities can result from disease of the testes (primary hypogonadism) or disease of the pituitary or hypothalamus (secondary hypogonadism). Currently, the clinical features of male hypogonadism are sufficiently well-recognized, the causes are well-known, and the tests of the hypothalamic-pituitary-testicular axis are accurate enough for the diagnosis in most patients. Testosterone, the focus hormone of this book, is used in different forms and routes of administration. Several authors unravel its peculiarities and assist in choosing the most suitable form in each case, as well as the possible risks of its misuse or even abuse in men and women, seeking alternatives to help patients in this situation.

Testosterone Resistance
Testosterone Resistance

Author: Malcolm Carruthers, MD

Publisher: Xlibris Corporation

Published: 2016-03-09

Total Pages: 275

ISBN-13: 1514449110

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This is a controversial account of why, because of the barriers to testosterone action in the body, men can have normal levels of testosterone but still have life-, love-, and health-wrecking symptoms of testosterone deficiency which need treatment. The deficiency is increasingly being linked to common and serious medical conditions such as obesity, diabetes, heart and circulatory disorders, and even Alzheimers disease. This has clearly been shown by the authors pioneering research publications as well as those of other colleagues and researchers worldwide. However, in the majority of cases, they are often denied this because of the lack of understanding of the medical profession and other authorities regulating the treatment. This is a wake-up call to both doctors and patients alike to treat the symptoms of testosterone deficiency and related conditions with what the author argues is the most effective, safest, and economic form of preventive medicine of the twenty-first century.

Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles
Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles

Author: P. Chanson

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 252

ISBN-13: 3662070197

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At the beginning of the 20th century, life expectancy at birth in North America and Western Europe was around 50 years of age. Nowadays, women have gained more than 30 years of age and men are trailing closer. However, according to several sociologists such as Louis Chauvel, the notion of a "greying society" is not entirely adequate since aging people are physically and socially younger and more active for a longer time. Of course, the other side of the medal is to tackle the challenge of preventing age-associated chronic diseases. In this book the extensive field of research on neuroendocrine aging has been reviewed. Aging is one of the most complex biological processes determined by the interactions between genetic and environmental factors.