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Author: Sunghoon Kim
Publisher: Springer
Published: 2014-04-28
Total Pages: 355
ISBN-13: 9401787018
DOWNLOAD EBOOKThis book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
Author: Michael Ibba
Publisher: CRC Press
Published: 2005-04-01
Total Pages: 0
ISBN-13: 9781587061899
DOWNLOAD EBOOKBy virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.
Author: Anders Liljas
Publisher: World Scientific
Published: 2013-06-06
Total Pages: 494
ISBN-13: 9814531804
DOWNLOAD EBOOKThis highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.
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Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
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Publisher: Academic Press
Published: 2020-10-23
Total Pages: 440
ISBN-13: 0128202610
DOWNLOAD EBOOKBiology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series
Author: Walt Ream
Publisher: Elsevier
Published: 2003-02-28
Total Pages: 322
ISBN-13: 0080479510
DOWNLOAD EBOOKMolecular Microbiology Laboratory is designed to teach molecular biology techniques to upper level undergraduates majoring in the life sciences. An extremely detailed lab preparation manual for teaching assistants accompanies the lab book and contains a general discussion of scientific writing and critical reading, as well as detailed instructions for preparation and peer review of lab reports. Each experimental unit is accompanied by a number of additional writing exercises based upon primary journal articles. The studies in these articles employ the techniques that the students are learning in the lab exercises, which reinforces their understanding of the material. These are techniques that students in any biological science will need to know, making this manual applicable to any life science curriculum.Key Features* Not a typical cookbook lab exercise, offers students the excitement and intellectual challenge of characterizing true unknowns. They could discover a new species! * Success rate greater than 85% for the entire experiment, even with very inexperienced students. * The ONLY manual that incorporates writing exercises into the curriculum. * Co-authored by Dr. Janine Trempy, one of four senior editors of the Journal of Microbiology Education, published by the American Society for Microbiology.
Author: Stefan Jurga
Publisher: Springer
Published: 2016-07-29
Total Pages: 456
ISBN-13: 3319341758
DOWNLOAD EBOOKThis volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Author: Koji Tamura
Publisher: MDPI
Published: 2018-03-23
Total Pages: 203
ISBN-13: 3038427691
DOWNLOAD EBOOKThis book is a printed edition of the Special Issue "The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick" that was published in Life
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Publisher: Academic Press
Published: 2009-07-24
Total Pages: 334
ISBN-13: 0080921639
DOWNLOAD EBOOKBy combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Author: Nikolai N. Smirnov
Publisher: Academic Press
Published: 2017-06-01
Total Pages: 420
ISBN-13: 0128052813
DOWNLOAD EBOOKPhysiology of the Cladocera, Second Edition, is a much-needed summary of foundational information on these increasingly important model organisms. This unique and valuable review is based on the world's literature, including Russian research not previously widely available, and offers systematically arranged data on the physiology of Cladocera, assisting with explanation of their life and distribution. It features the addition of new sections and a vast amount of new information, such as the latest data on feeding, nutrition, pathological physiology, chemical composition, neurosecretion, and behavior, as well as hormonal regulation, antioxidants, and the biochemical background of effects of natural and anthropogenic factors. Additional expertly updated contributions in genetics and cytology, and a new chapter in embryology, round out the physiological chapters, and provide comprehensive insight into the state of knowledge of Cladocera and their underlying mechanisms. Cladocera crustaceans have become globally studied for many purposes, including genetic, molecular, ecological, environmental, water quality, systematics, and evolutionary biology research. Since the genome of Daphnia was sequenced and published, that system has gained much wider exposure, also leading to a rapidly growing awareness of the importance of understanding physiological processes as they relate to evolutionary and ecological genomics as well as ecogenomic toxicology. However, the physiological background on Cladocera has been fragmentary (including on the other 700 known species besides Daphnia), despite the extensive literature on species identification and morphology. This work addresses this issue by collecting and synthesizing from the literature the state of knowledge of cladoceran physiology, including discussion on both adequately and inadequately investigated fields, and thus directions of future research. - Summarizes fundamental information obtained in recent years, including on steroids, antioxidants, hormones, nanoparticles, and impact of wastewater of pharmaceutical industries - Provides the foundational information needed for scientists and practitioners from a variety of fields, including conservation and evolutionary biology, genomics, ecology, ecotoxicology, comparative physiology, limnology, zoology–carcinology, and water quality assessment - Features coverage of both Daphniids and representatives of other families, with attention drawn to little-studied aspects of their physiology, especially of those living in the litt oral zone - Includes guidance to the literature on cladoceran physiology in four languages - Discusses advantages and shortcomings of Cladocera as experimental animals and indicators of water quality
