This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
This volume provides a broad and critical presentation of the behavioral and psychosocial treatments of Latinxs with dementia in the United States (U.S.) and across a representative sample of Spanish-speaking countries in the world. The compendium of chapters, written by researchers, practitioners, and policy analysts from multiple disciplines provides a deep exploration of the current state of dementia care for Latinxs in the U.S. and around the globe. The volume is designed to increase and strengthen the collective scientific and sociocultural understanding of the epidemiological and biopsychosocial factors, as well as the overlapping systemic challenges that impact diagnosis and symptom management of Latinxs with dementia. The authors introduce policy options to reduce risk factors for dementia and present culturally-responsive interventions that meet the needs of Latinx patients and their caregivers. Highlighted topics featured in the book include: Contextual, cultural, and socio-political issues of Latinxs with dementia. New meta-analysis of dementia rates in the Americas and Caribbean. Dementia-related behavioral issues and placement considerations. Educational, diagnostic, and supportive psychosocial interventions. Pharmacological, non-pharmacological, and ethnocultural healthcare interventions. Intersectionality as a practice of dementia care for sexual and gender minoritized Latinxs. Prescriptions for policy and programs to empower older Latinxs and their families. Caring for Latinxs with Dementia in a Globalized World: Behavioral and Psychosocial Treatments is a resource that accentuates and contextualizes the heterogeneity in nationality, immigration, race, sexual orientation, gender, and political realities. It is a key reference for a wide range of fields inclusive of demography, geriatrics, gerontology, medicine, mental health, neurology, neuropsychology, nursing, occupational therapy, pharmacology, psychiatry, psychology, rehabilitation, social work, sociology, and statistics all of which, collectively, bear on the problem and the solutions for better care for Latinxs affected by dementia.
Envejecimiento y las demencias presenta los últimos avances neurocientíficos, neuropsicológicos y clínicos sobre el envejecimiento y la demencia desde un acercamiento interdisciplinario, reconociendo las particularidades del paciente de habla hispana. Asimismo, se comparte una visión emergente sobre la promoción del envejecimiento positivo y saludable como punto de partida para la prevención de las alteraciones neurocognoscitivas y las demencias en el adulto mayor. Envejecimiento y las Demencias es una obra práctica y actualizada con la más reciente literatura científica disponible, enriquecida con la amplia experiencia clínica de sus autores. El libro aborda los trastornos neurocognoscitivos y las demencias más prevalentes. En cada capítulo se presenta la definición de la condición, datos epidemiológicos, se identifica la patología con énfasis en los procesos neurofisiológicos implicados, se describen los procesos pertinentes de evaluación neuropsicológica y los tratamientos e intervenciones basados en evidencia que existen en la actualidad. Esto lo convierte en una referencia obligada para los estudiantes y profesionales de la salud interesados en actualizar sus conocimientos en un tema de prioridad para las sociedades del siglo XXI.
This booklet summarizes what scientists have learned so far and where research is headed. There is no definitive evidence yet about what can prevent Alzheimer's or age-related cognitive decline. What we do know is that a healthy lifestyle-one that includes a healthy diet, physical activity, appropriate weight, and no smoking-can maintain and improve overall health and well-being. Making healthy choices can also lower the risk of certain chronic diseases, like heart disease and diabetes, and scientists are very interested in the possibility that a healthy lifestyle might have a beneficial effect on Alzheimer's as well. In the meantime, as research continues to pinpoint what works to prevent Alzheimer's, people of all ages can benefit from taking positive steps to get and stay healthy.
How can positive psychology approaches help us to understand the process of adjustment to, and living well with dementia? As accounts of positive experiences in dementia are increasingly emerging, this book reviews current evidence and explores how psychological constructs such as hope, humour, creativity, spirituality, wisdom, resilience and personal growth may be linked with wellbeing and quality of life in dementia. Expert contributors from a range of academic and clinical backgrounds examine the application of positive psychological concepts to dementia and dementia care practice. The lived experiences of people with dementia are central to the book, and their voices bring life to the ideas explored, highlighting how positive experiences in dementia and dementia care are possible.
The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.
A high percentage of patients with dementia experience debilitating pain. Untreated, it can result in mental and physical impairment; a higher frequency of neuropsychiatric symptoms such as agitation, depression, and sleep problems; and adverse events such as falls, hallucination, and even death. With the help of Pain in Dementia, you can learn new ways to give these patients a better quality of life! A multidisciplinary team of leading experts navigates the complex clinical challenges associated with pain among these patients. They identify the sources of pain, even in patients who have trouble communicating, and recommend the most effective pain treatment options.
Cognitive Stimulation Therapy (CST) has made a huge global, clinical impact since its inception, and this landmark book is the first to draw all the published research together in one place. Edited by experts in the intervention, including members of the workgroup who initially developed the therapy, Cognitive Stimulation Therapy for Dementia features contributions from authors across the globe, providing a broad overview of the entire research programme. The book demonstrates how CST can significantly improve cognition and quality of life for people with dementia, and offers insight on the theory and mechanisms of change, as well as discussion of the practical implementation of CST in a range of clinical settings. Drawing from several research studies, the book also includes a section on culturally adapting and translating CST, with case studies from countries such as Japan, New Zealand and Sub-Saharan Africa. Cognitive Stimulation Therapy for Dementia will be essential reading for academics, researchers and postgraduate students involved in the study of dementia, gerontology and cognitive rehabilitation. It will also be of interest to health professionals, including psychologists, psychiatrists, occupational therapists, nurses and social workers.
This book brings together a cutting-edge selection of the most current applications of mindfulness-based cognitive therapy (MBCT), giving clinicians as well as researchers a concise guide to current and future directions. Each chapter begins with in illustrative case study to give readers an example of how MBCT would be used in the clinical setting, followed by an overview of the condition, the theoretical rationale for using MBCT, modifications of MBCT for that disorder, evidence for MBCT use. Chapters also discuss practical considerations of MBCT, including patient selection, home practice, group size, format, and facilitator training. Written by some of the world’s leading physicians using MBCT, Mindfulness-Based Cognitive Therapy: Innovative Applications is of great value to psychiatrists, psychologists, social workers, and therapists.
