A group of highly esteemed aerosol scientists - physicists, chemists, biologists and toxicologists - met in Warsaw in September, 1995, in order to discuss the latest developments in the field of aerosol health subjects, including inhalation, lung transport and deposition. The relationship of these subjects with the environment was also addressed. This book contains the proceedings of the Workshop and also documents the ensuing panel discussions. Subject Index included.
Inhaled Particles integrates all that is known about inhaled particles in a unified treatment. It aims to provide a scientific framework essential to a reasonable understanding of inhaled particles. The emphasis is placed on demonstrating the key roles of lung morphology on airflow and particle transport as well as identifying physical and biological factors that influence deposition. Special attention is paid to maintaining consistency of treatment and a balance between theoretical modeling and experimental measurements. The book covers all important aspects of inhaled particles including inhalability, aerosol dispersion, particle deposition, and clearance. It reviews concisely the basic background of lung morphology, respiratory physiology, aerodynamics, and aerosol science pertinent to the subject. Essential aspects of health effects and applications are also included. An easy-to-read, self contained introduction to the field An excellent source of updated research information Useful for students and professionals in aerosol science, environmental health science, occupational hygiene, health physics and biomedical engineering
A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system. Three main themes are discussed: Nanoparticle sources and production Nanoparticle inhalation and deposition Toxicological and medical consequences of nanoparticles Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.
This unique textbook examines the basic health and environmental issues associated with air pollution including the relevant toxicology and epidemiology. It provides a foundation for the sampling and analysis of air pollutants as well as an understanding of international air quality regulations. Written for upper-level undergraduate and introductory graduate courses in air pollution, the book is also a valuable desk reference for practicing professionals who need to have a broad understanding of the topic. Key features: - Provides the most up-to-date coverage of the basic health and environmental issues associated with air pollution. - Offers a broader examination of air pollution topics, beyond just the meteorological and engineering aspects of air pollution. - Includes the following Instructor Resources: Instructor's Manual, PowerPoint Presentations, and a TestBank. The Phalens have put together a timely book on a critically important topic that affects all of us -- air pollution - and they do so in a new and highly relevant way: they consider the broad societal health impacts from a fundamental science viewpoint. The epidemiology, toxicology, and risks of air pollutants are included, and ethical issues of concern are highlighted. This book is a must-read for students who wish to become professionals in the air quality field and for students of environmental science whose work includes air pollution issues. The book is a significant contribution to the discipline." - Cliff I. Davidson, Director, Center for Sustainable Engineering; Thomas C. and Colleen L. Wilmot Professor of Engineering, Syracuse Center of Excellence in Environmental and Energy Systems and Department of Civil and Environmental Engineering, Syracuse University "Truly, human well-being and public health in the 21st century may hinge on our ability to anticipate, recognize, evaluate, control, and confirm responsible management of air pollution. This timely, informative, and insightful text provides a solid introduction for students and a technically sound handbook for professionals seeking literacy and critical thinking, real-life examples, understanding (not just rote applications), opportunities for continuous improvement, and modern tools for assessing and managing current and evolving air pollution challenges." - Mark D. Hoover, PhD, CHP, CIH Aerosol and health science researcher, author, and editor
As more attention is dedicated to understanding the occupational health risks associated with the industrial manufacture and use of nanotechnology, Aerosols Handbook: Measurement, Dosimetry, and Health Effects is a timely presentation of time-tested research in the field of aerosol science. The book covers a multitude of topics in indoor, outdoor,
This wide-ranging, comprehensive reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract-utilizing an inter-disciplinary approach that integrates advances in physics, chemistry, and engineering with the epidemiological and biomedical sciences, and focusing on the dynamics of particl
Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.
This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.
Small invisible particles in the urban air, especially those produced by human activities, have recently stimulated intense scrutiny, debate, regulation, and legal proceedings. The stakes are high, both with respect to health impacts and economic costs, and the methods used previously to resolve similar issues are no longer adequate. Everyone on earth inhales thousands to millions of particles in each breath, so if urban particulate air pollution—particulate matter (PM)—is significantly hazardous, the negative impact on health could be staggering. Yet the activities that generate PM, such as farming, manufacturing, mining, transportation, and generating electricity, are themselves essential to human health and welfare. Scientists, regulators, legislators, activists, judges, lawyers, journalists, and representatives of the business community are actively involved in addressing the question of what should be done. This complex issue presents opportunities for critically assessing the relevant knowledge and for adopting more rigorous approaches to this and similar problems. What is the PM controversy, and why is it a good case study for how science and public policy might better interface? The PM controversy is the sum of the frequently heated debates related to the potential health risks from urban PM.
