Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.
This book reviews the progress made in salivary diagnostics during the past two decades and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of “salivaomics” is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering for future diagnostics is explored. The book closes by considering legal issues and barriers to salivary diagnostic development. Advances in Salivary Diagnostics will be an informative and stimulating reference for both practitioners and students.
Saliva is a complex fluid that maintains oral health and has many physiological functions. It is a noninvasive diagnostic fluid as well. Lately, salivary diagnostics has proven its potential to reach clinical practice in the near future for the early detection, diagnosis, and monitoring of various diseases. Salivary Glands - New Approaches in Diagnostics and Treatment is a comprehensive reference, which brings together information on salivary secretion and its disorders, the novel salivary diagnostic methods for numerous diseases, and new techniques in the treatment of salivary diseases. This book contains information for a diverse audience, including dentists, oral biologists, experimental biologists, molecular biologists, oncologists, radiologists, oral and maxillofacial surgeons, and otorhinolaryngologists.
This book provides the first comprehensive overview of the emerging field of interdisciplinary salivary bioscience. It serves as a foundational reference guide to the collection, analysis, and interpretation of salivary data, as well as its myriad applications in medicine, surveillance and public health. The ease and non-invasive nature of saliva collection makes it highly useful in diverse fields such as pediatrics, dentistry, neuroscience, psychology, animal welfare and precision medicine. This book introduces students and scientists alike to the vast potential of salivary bioscience in both research and practice.
Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems. - Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers - Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications - Offers an insight into how to develop cost-effective diagnostics for early detection of cancer
This monograph equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection. All the methods employed in the oral cancer context are considered, from simple ones like oral screening to more complex emerging optical methods and biomarker identification strategies. Individual chapters focus on conventional oral screening and application of vital stains, optical methods like white light based fluorescence-reflectance imaging, narrow band imaging, direct-oral-microscopy, and more advanced methods like optical coherence tomography, an in-vivo optical biopsy technique, and photo-acoustic imaging that allows visualization of deeper tissue changes. Novel electrical methods like bio-impedance assessment, occult biophysical methods like crystallization test, and the most promising salivary biomarkers and point-of-care opportunities are covered. Helpful information is also provided on essential topics including, oral potentially malignant disorders, biological aspects and molecular mechanisms underlying oral cancer progression, global epidemiology, concept of diagnostic delays, traditional imaging, and classic histopathology and microscopic features. The newer techniques are currently of active research interest, and can soon become powerful chair-side tools with potential to reduce diagnostic delays and improve survival.
Health professionals are more and more aware of the importance of saliva for oral health and well-being. As saliva secretion is steadily compromised with advancing age, it becomes a factor of concern in societies with an aging population, especially with a growing number of people who keep their own teeth. The numerous functions of saliva, like antimicrobial activity, lubrication, wound healing and its role in taste experience are only truly recognized when saliva secretion is hampered. In medical diagnostics, saliva shows its value as a safe and economical alternative to blood. This publication provides a comprehensive overview of the latest developments in salivary research by some of the world’s leading experts in the field. Chapters deal with various aspects: anatomy and physiology, e.g. regeneration of salivary glands, saliva functions, e.g. its protective and rheological properties, and diagnostics and disorders, e.g. xerostomia and hypersalivation. This book is not only recommended to basic scientists working in the field of oral biology, but also to dental students, dentists and health professionals who want to know more about one of the most underestimated bodily fluids.
The Second Edition of The Milan System for Reporting Salivary Gland Cytopathology, like the First Edition, represents a collaborative effort by a multidisciplinary group of cytopathologists, surgical pathologists, molecular pathologists, radiologists, and head and neck surgeons. This international group shares the goal of creating a practical and uniform reporting system for salivary gland fine needle aspiration (FNA). This book is organized into six general diagnostic categories: “Non-Diagnostic,” “Non-Neoplastic,” “Atypia of Undetermined Significance (AUS),” “Neoplasm: Benign,” “Neoplasm: Salivary Gland Neoplasm of Uncertain Malignant Potential (SUMP),” “Suspicious for Malignancy,” and “Malignant.” It includes definitions, morphologic criteria, and explanations for each of the diagnostic categories. Specific chapters are dedicated to the application of the latest available ancillary studies, radiologic features of salivary gland lesions, clinical management, and histological considerations including updates from the most recent 5th Edition WHO blue book. The Milan System for Reporting Salivary Gland Cytopathology 2nd Edition represents an essential step towards increasing the overall effectiveness of salivary gland FNA and fostering better communication between clinicians and between institutions to improve overall patient care.
Textbook and Color Atlas of Salivary Gland Pathology: Diagnosis and Management provides its readers with a new, landmark text/atlas of this important discipline within oral and maxillofacial surgery, otolaryngology/head and neck surgery, and general surgery. Written by well-established clinicians, educators, and researchers in oral and maxillofacial surgery, this book brings together information on the etiology, diagnosis and treatment of all types of salivary gland pathology. Clear and comprehensive, the Textbook and Color Atlas of Salivary Gland Pathology offers complete explanation of all points, supported by a wealth of clinical and surgical illustrations to allow the reader to gain insight into every facet of each pathology and its diagnosis and treatment.
