Advanced Glycation End-products
Advanced Glycation End-products

Author: Patrik Bast

Publisher: Nova Science Publishers

Published: 2020

Total Pages: 144

ISBN-13: 9781536175479

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"Advanced Glycation End-Products: Sources and Effects attempts to describe the role of advanced glycation end-products, particularly dietary advanced glycation end-products, in the pathological expansion of adipose tissue as well as their implications in the development of obesity associated complications. The effects of advanced glycation end-products on vasculature and their pathological implications are also described, focusing on the epigenetic mechanisms (particularly that of miRNA) modulating their effects. The authors summarize the information available on the impact of hyperglycemia on the influencing factors of non-enzymatic glycosylation, the formation of advanced glycation end-products, and the role of advanced glycation end-products and their specific receptors in diabetes. The role of advanced glycation end-products to diabetic complications is examined in conjunction with the protective role of the endogenous secretory receptor for advanced glycation end-products (esRAGE) and the therapeutic interventions that would mimic esRAGE activity. In closing, poly-L-lysine modified with advanced glycation end-products is prepared and used as an antigen to generate a single-chain fragment variable monoclonal antibody (scFv mAb) through phage display technology"--

Molecular Basis of Nutrition and Aging
Molecular Basis of Nutrition and Aging

Author: Marco Malavolta

Publisher: Academic Press

Published: 2016-04-15

Total Pages: 786

ISBN-13: 0128018275

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Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. - Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging - Explores how nutritional factors are involved in the pathogenesis of aging across body systems - Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Mechanisms Linking Aging, Diseases and Biological Age Estimation
Mechanisms Linking Aging, Diseases and Biological Age Estimation

Author: Sara C. Zapico

Publisher: CRC Press

Published: 2017-03-27

Total Pages: 203

ISBN-13: 1315354209

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This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

Obesity and Diabetes
Obesity and Diabetes

Author: Joel Faintuch

Publisher: Springer Nature

Published: 2020-12-14

Total Pages: 994

ISBN-13: 3030533700

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Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians’ offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.

Nutrition in Kidney Disease
Nutrition in Kidney Disease

Author: Laura D. Byham-Gray

Publisher: Springer Science & Business Media

Published: 2014-01-23

Total Pages: 495

ISBN-13: 1627036857

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Nutrition in Kidney Disease, Second Edition addresses the relationships between nutrition and (1) normal kidney function and disease, (2) the progressiveness of chronic kidney disease (CKD) and strategies to prevent further compromise, and (3) the treatment and management of kidney failure especially during medical crises, such as acute kidney injury and its consequent nutritional therapies (e.g., enteral and parenteral nutrition). Demographic patterns, trends and outcomes in the current health care systems are explored in the United States and abroad. Disease prevention and management are presented over the entire lifespan, beginning with pregnancy, followed by infancy, childhood, adolescence, and adulthood, concluding with the elder years. Foundations for clinical practice are established by devoting a complete section towards conducting a comprehensive nutritional assessment, comprising of anthropometric, biochemical, clinical, physical parameters and psychosocial concerns unique to the kidney disease population. Nutritional therapy is also discussed across the spectrum of kidney disease, and pertinent aspects critical to successful management of disorders and conditions, such as bone disease, obesity, and nephrotic syndrome are explored. Nutrition in Kidney Disease, Second edition highlights cutting edge research in regards to exercise and functional outcomes, malnutrition and the inflammatory response, experimental therapies, and the use of complementary and alternative medicine, with a special emphasis on relevant preventative strategies.

Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus
Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus

Author:

Publisher: Academic Press

Published: 2013-12-24

Total Pages: 513

ISBN-13: 0128002948

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Diabetes mellitus is a disease with tremendous health and economic burden. A better understanding of how normal glucose homeostasis is maintained and the pathogenesis is important to identify new ways for diabetes treatment. This book addresses multiple aspects of this area of research. - Written by experts in the field - Informs on important topics related to the regulation of glucose homeostasis and the pathogenesis of diabetes mellitus, a field of intense research interest

Dietary Interventions in Liver Disease
Dietary Interventions in Liver Disease

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2019-01-10

Total Pages: 430

ISBN-13: 012814467X

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Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. - Provides information on agents that affect metabolism and other health-related conditions in the liver - Explores the impact of composition, including differences based on country of origin and processing techniques - Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function

New Look to Phytomedicine
New Look to Phytomedicine

Author: Mohd Sajjad Ahmad Khan

Publisher: Academic Press

Published: 2018-10-23

Total Pages: 711

ISBN-13: 0128146206

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New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research. - Compiles up-to-date information on the chemotherapeutics used in the treatment of infective and metabolic disorders - Presents advancements in the discovery of new drugs from plants using molecular and nanotechnology tools - Examines detailed information on the use of herbals agents in cancer, HIV and other ailments, including diabetes, malaria and neurological disorders

The A. G. E. Food Guide
The A. G. E. Food Guide

Author: Helen Vlassara

Publisher:

Published: 2017-04

Total Pages: 0

ISBN-13: 9780757004292

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"All foods contain naturally ocurring toxic substances called AGEs - advanced glycation end products. Studies have shown that a buildup of AGEs increases oxidation and free radicals, hardens tissue, and creates chronic inflammation, leading to a host of illnesses. While many foods contain high AGE levels, many others contain very little. By knowing the best foods to choose and their optimal preparation methods, you can lower your consumption of these harmful substances. The AGE Food Guide is designed to help. This comprehensive guide lists hundreds of common foods and their AGE levels. In an easy-to-follow format, the foods are listed both alphabetically and within categories for quick and easy access." -- p. [4] of cover.

Textbook of Aging Skin
Textbook of Aging Skin

Author: Miranda A. Farage

Publisher: Springer Science & Business Media

Published: 2009-12-02

Total Pages: 1255

ISBN-13: 3540896554

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This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.