Therapeutics and Human Physiology
Therapeutics and Human Physiology

Author: Elsie E. Gaskell

Publisher: Oxford University Press

Published: 2013-02-14

Total Pages: 228

ISBN-13: 0199655294

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The Integrated Foundations of Pharmacy series is for those at the start of their journey to become a pharmacist. It helps students understand how a drug molecule is made and then turned into a medicine; the role they will have when dispensing; and how the medicine works in the body. Most importantly, it shows how all of these aspects come together.

Respiratory Care Anatomy and Physiology
Respiratory Care Anatomy and Physiology

Author: Will Beachey, PhD, RRT, FAARC

Publisher: Elsevier Health Sciences

Published: 2012-10-22

Total Pages: 483

ISBN-13: 0323078664

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Perfect for both practicing therapists and students in respiratory therapy and associated professions, this well-organized text offers the most clinically relevant and up-to-date information on respiratory applied anatomy and physiology. Content spans the areas of basic anatomy and physiology of the pulmonary, cardiovascular, and renal systems, and details the physiological principles underlying common therapeutic, diagnostic, and monitoring therapies and procedures. Using a clear and easy-to-understand format, this text helps you take a more clinical perspective and learn to think more critically about the subject matter. Open-ended concept questions require reasoned responses based on thorough comprehension of the text, fostering critical thinking and discussion. Clinical Focus boxes throughout the text place key subject matter in a clinical context to connect theory with practice. Chapter outlines, chapter objectives, key terms, and a bulleted chapter summary highlight important concepts and make content more accessible. Appendixes contain helpful tables and definitions of terms and symbols. NEW! Chapter on the physiological basis for treating sleep-disordered breathing clarifies the physiological mechanisms of sleep-disordered breathing and the various techniques required to treat this type of disorder. NEW! Reorganization of content places the section on the renal system before the section on integrated responses in exercise and aging to create a more logical flow of content. NEW! More Clinical Focus scenarios and concept questions provide additional opportunities to build upon content previously learned and to apply new information in the text.

Rational Therapeutics for Infants and Children
Rational Therapeutics for Infants and Children

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2000-04-07

Total Pages: 135

ISBN-13: 0309183642

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The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be convened to conduct a dialogue and exchange information related to the development of drugs, biologics, and medical devices. Members have expertise in clinical medicine, pediatrics, clinical pharmacology, health policy, health insurance, industrial management, and product development; and they represent interests that address all facets of public policy issues. From time to time, the Roundtable requests that a workshop be conducted for the purpose of exploring a specific topic in detail and obtaining the views of additional experts. The first workshop for the Roundtable was held on April 14 and 15, 1998, and was entitled Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making. The summary on that workshop is available from IOM. This workshop summary covers the second workshop, which was held on May 24 and 25, 1999, and which was aimed at facilitating the development and proper use of drugs, biologics, and medical devices for infants and children. It explores the scientific underpinnings and clinical needs, as well as the regulatory, legal, and ethical issues, raised by this area of research and development.

Allostasis, Homeostasis, and the Costs of Physiological Adaptation
Allostasis, Homeostasis, and the Costs of Physiological Adaptation

Author: Jay Schulkin

Publisher: Cambridge University Press

Published: 2004-10-25

Total Pages: 388

ISBN-13: 9780521811415

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The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.

The Physiological Basis of Rehabilitation Medicine
The Physiological Basis of Rehabilitation Medicine

Author: John A. Downey

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 785

ISBN-13: 1483193993

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The Physiological Basis of Rehabilitation Medicine: Second Edition presents a comprehensive examination of the management of patients with functional impairments due to disease or trauma. It discusses the distinction between disabilities and impairments per se. It addresses the method in which the human body adapts and compensates for the stress produced by physical injuries. Some of the topics covered in the book are the physiology of cerebellum and basal ganglia; description of upper and lower motor neurons; anatomy of the vascular supply to the brain; characteristics of the autonomic nervous system; structure, chemistry, and function of skeletal muscle; the receptors in muscle; and cardiopulmonary physiology. The role of muscle spindles in perception of limb position and movement is fully covered. An in-depth account of the physiology of synovial joints and articular cartilage are provided. The cellular and glandular components of the skin are completely presented. A chapter is devoted to the factors involve in wound healing. Another section focuses on the nerve conduction and neuromuscular transmission. The book can provide useful information to doctors, dermatologists, students, and researchers.

Physiological Control Systems
Physiological Control Systems

Author: Michael C. K. Khoo

Publisher: John Wiley & Sons

Published: 2018-04-12

Total Pages: 456

ISBN-13: 1119058805

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A guide to common control principles and how they are used to characterize a variety of physiological mechanisms The second edition of Physiological Control Systems offers an updated and comprehensive resource that reviews the fundamental concepts of classical control theory and how engineering methodology can be applied to obtain a quantitative understanding of physiological systems. The revised text also contains more advanced topics that feature applications to physiology of nonlinear dynamics, parameter estimation methods, and adaptive estimation and control. The author—a noted expert in the field—includes a wealth of worked examples that illustrate key concepts and methodology and offers in-depth analyses of selected physiological control models that highlight the topics presented. The author discusses the most noteworthy developments in system identification, optimal control, and nonlinear dynamical analysis and targets recent bioengineering advances. Designed to be a practical resource, the text includes guided experiments with simulation models (using Simulink/Matlab). Physiological Control Systems focuses on common control principles that can be used to characterize a broad variety of physiological mechanisms. This revised resource: Offers new sections that explore identification of nonlinear and time-varying systems, and provide the background for understanding the link between continuous-time and discrete-time dynamic models Presents helpful, hands-on experimentation with computer simulation models Contains fully updated problems and exercises at the end of each chapter Written for biomedical engineering students and biomedical scientists, Physiological Control Systems, offers an updated edition of this key resource for understanding classical control theory and its application to physiological systems. It also contains contemporary topics and methodologies that shape bioengineering research today.

Biased Signaling in Physiology, Pharmacology and Therapeutics
Biased Signaling in Physiology, Pharmacology and Therapeutics

Author: Brian J Arey

Publisher: Elsevier

Published: 2014-06-05

Total Pages: 317

ISBN-13: 0124115071

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Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. - Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families - Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease - Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling