Building on the success of their Global Street Design Guide, the National Association of City Transportation Officials (NACTO)-Global Designing Cities Initiative (GDCI) Streets for Kids program has developed child-focused design guidance to inspire leaders, inform practitioners, and empower communities around the world to consider their city from the eyes of a child. The guidance in Designing Streets for Kids captures international best practices, strategies, programs, and policies that cities around the world have used to design streets and public spaces that are safe and appealing to children from their earliest days. The guidance also highlights tactics for engaging children in the design process, an often-overlooked approach that can dramatically transform how streets are designed and used.
This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The science that created this advance and its future promise will be discussed. Phillip Allen Sharp is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for “the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence. He works in Institute Professor Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, US. Este libro recoge los resúmenes de la «Innovation in Pharmacy: Advances and Perspectives» que tuvo lugar en Salamanca (España) en septiembre de 2018. La ciencia primitiva de la química y la microbiología fue la fuente de la mayoría de las drogas hasta la revolución de la ingeniería genética a mediados de la década de 1970. Luego, la biotecnología puso a disposición agentes proteínicos novedosos como interferones, factores sanguíneos y anticuerpos monoclonales que han cambiado la farmacia moderna. Durante el año pasado, surgió una nueva farmacia de oligonucleótidos a partir de la ciencia de la expresión génica, como el empalme de ARN y la interferencia de ARN. La capacidad de diseñar agentes terapéuticos a partir de secuencias genómicas transformará el tratamiento de muchas enfermedades. La ciencia que creó este avance y su promesa futura será discutida. Phillip Allen Sharp es un genetista y biólogo molecular estadounidense que co-descubrió el empalme de ARN. Compartió el Premio Nobel de 1993 en Fisiología o Medicina con Richard J. Roberts por "el descubrimiento de que los genes en eucariotas no son cadenas contiguas, sino que contienen intrones, y que el empalme del ARN mensajero para eliminar esos intrones puede ocurrir de diferentes maneras, produciendo diferentes proteínas de la misma secuencia de ADN. Trabaja en el Instituto Profesor Koch Institute for Integrative Cancer Research, Instituto Tecnológico de Massachusetts (MIT), Cambridge, MA, EE. UU.
Some five hundred miles of superhighway run between the Rio Grande and the Red River-present-day Interstate 35. This towering achievement of modern transportation engineering links 7.7 million people, yet it all evolved from a series of humble little trails.
Traces Galveston's emergence as a key American port city: from its initial conception by risk-taking businessmen and daring civic leaders through the thirty-five years it took to realize the dreams of a world-class harbor.
This edition is abridged and annotated with updated information.A judge from Prussia. A French Texas Ranger. Emigrants from all over the U.S.Their names and stories are mostly now forgotten but were recorded in this 1900 volume by Andrew Jackson Sowell. They were mostly young, hardy, and looking for new opportunities in land they felt was wide open but, in fact, was inhabited by Native Americans. The lives of these early pioneers is part of the history of the American West.The original bound edition of this book ran over 1100 pages and most of that content is here. It's the story of an incredibly violent and adventurous time that was lived by the people whose stories you find here. Sowell talked to them all and created one of the most interesting collections of personal histories of the wild West.
Seventy million dollars in fifty-five years. From Texas' annexation in 1845 until the turn of the twentieth century, the U.S. Army pumped at least that much or more into the economy of the fledgling state, a fact that directly challenges the popular heritage of Texas as the state with roots of pioneer capitalism and fervent independence. In The U.S. Army and the Texas Frontier Economy, 1845-1900, Thomas T. Smith sheds light on just who bankrolled the evolution of Texas into viable statehood. Smith draws on extensive research gathered from both government archives and Texas army posts in order to evaluate the symbiotic relationship between army quartermasters and the economy of the young state. Texas was the army's largest--and most costly--engagement, absorbing up to thirty percent of the total operating budget and channeling that currency into the commercial development of its frontier. Smith expands on historian Robert Wooster's theory that the military was engaged in an alliance with the political authority in Texas, and using documents such as army contracts for freighting, foraging, and fort leasing, he illustrates how federal fiscal activity spurred commercial growth for the citizens of Texas. Besides the obvious development of towns on the skirts of military bases and of roads between them, the establishment of military spending as a bedrock of the Texas economy and the protector of middle class interests shaped the future of the state's commercial prosperity. Writing with exceptional detail and clarity, Smith traces the emergence of the army's influence and includes analyses of information on army spending and development such as the introduction of army weather and telegraph services to the state, as well as accounts of real estate transactions involving the fort building program. Smith also accounts for army failures, maintaining that no one was truly prepared for the reality of western expansion. As an examination of the complex yet mutually beneficial economic relationship between the nation and the state, The U.S. Army and the Texas Frontier Economy, 1845-1900 is ideal for anyone interested in the early days of the state as well as in U.S. military and frontier history.
Capitalism and Classical Social Theory, Second Edition offers solid coverage of the classical triumvirate (Marx, Durkheim, and Weber), but also extends the canon strategically to include Simmel, four early female theorists, and the writings of Du Bois.
"The aim of this report is to define and review this "semi-aquaculture practice", which has been more accurately named "capture-based aquaculture." -- Preface.
The role of water in our communities, from local to regional and right up to global levels, poses a series of key questions about climate change, about the anthropogenic impact on the environment, and about all the interconnected actions and events that affect the availability and quality of the resource. All these questions share a common demand for more scientific knowledge and information. In this particular context the disciplinary boundaries are fading, and there is a growing need to create broader connections and wider collaborative interdisciplinary groups, aimed at building an integrated knowledge-base to serve not only stakeholders but also the whole of society. Only in this way can we hope to respond effectively to the challenges and changing dynamics of human-hydrologic systems. Following this concept, contributors from multiple disciplinary backgrounds, such as Law Studies, Hydrogeology, Monitoring and Information Technologies, Geophysics, Geochemistry, Environmental Sciences, Systems Engineering, Economics and Social Studies, joined forces and interacted in this workshop. The present book reports the proceedings of this three-day ARW (Advanced Research Workshop), and explores different aspects of the environmental security assessment process, focusing on the assessment, monitoring and management of water resources, and giving an overview of the related scientific knowledge.
