Heme Oxygenase in Biology and Medicine

Heme Oxygenase in Biology and Medicine

Author: Nader G. Abraham

Publisher: Springer Science & Business Media

Published: 2002-08-31

Total Pages: 542

ISBN-13: 9780306472640

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Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.


Scientific Advances in STEM

Scientific Advances in STEM

Author: Yadir Torres

Publisher: Mdpi AG

Published: 2021-09-10

Total Pages: 362

ISBN-13: 9783036517759

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This book collects the publications of the special Topic Scientific advances in STEM: from Professor to students. The aim is to contribute to the advancement of the Science and Engineering fields and their impact on the industrial sector, which requires a multidisciplinary approach. University generates and transmits knowledge to serve society. Social demands continuously evolve, mainly because of cultural, scientific, and technological development. Researchers must contextualize the subjects they investigate to their application to the local industry and community organizations, frequently using a multidisciplinary point of view, to enhance the progress in a wide variety of fields (aeronautics, automotive, biomedical, electrical and renewable energy, communications, environmental, electronic components, etc.). Most investigations in the fields of science and engineering require the work of multidisciplinary teams, representing a stockpile of research projects in different stages (final year projects, master's or doctoral studies). In this context, this Topic offers a framework for integrating interdisciplinary research, drawing together experimental and theoretical contributions in a wide variety of fields.


Bioceramics 25

Bioceramics 25

Author: Vasile Iulian Antoniac

Publisher: Trans Tech Publications Ltd

Published: 2013-11-15

Total Pages: 451

ISBN-13: 3038262803

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Selected, peer reviewed papers from the 25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (BIOCERAMICS 25), November 7-10, 2013, Bucharest, Romania


BiomMedD V

BiomMedD V

Author: Iulian Antoniac

Publisher: Trans Tech Publications Ltd

Published: 2013-09-10

Total Pages: 181

ISBN-13: 3038262471

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Selected, peer reviewed papers from the 5th International Conference “Biomaterials, Tissue Engineering & Medical Devices” (BiomMedD 2012), August 29 – September 1, 2012, Constanta, Romania


The Engineer's Manual of Construction Site Planning

The Engineer's Manual of Construction Site Planning

Author: Jüri Sutt

Publisher: John Wiley & Sons

Published: 2013-05-28

Total Pages: 117

ISBN-13: 1118556070

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This handbook addresses problems facing the engineer when preparing to build, both during the contract bidding phase and after a contract has been concluded. It offers clear guidelines for planning the resources and machinery on site, as well as the safe positioning of roads, cranes, storage and temporary buildings. Site planning activities are presented here in logical sequence, offering an efficient and safe design of the construction site and of the temporary works. The book describes the process of engineering preparation of on-site construction works in all phases of the construction life-cycle, from the design phase - preparing the financial plan and procurement scheme for the owner before tendering the contract; the tendering phase; and after bid completion. A list of procedures is presented for planning the construction site in order to simplify the engineer’s work of site and temporary works planning. The Engineer’s Manual of Construction Site Planning is for all those involved in the planning of construction sites, construction managers, construction engineers and quantity surveyors, as well as for students in civil engineering and construction.


Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment

Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment

Author: Jorge Coelho

Publisher: Springer Science & Business Media

Published: 2013-03-15

Total Pages: 433

ISBN-13: 9400760108

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This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.


Biologically Responsive Biomaterials for Tissue Engineering

Biologically Responsive Biomaterials for Tissue Engineering

Author: Iulian Vasile Antoniac

Publisher: Springer

Published: 2014-10-15

Total Pages: 0

ISBN-13: 9781489992567

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Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.


Structure—Property Relationships in Polymers

Structure—Property Relationships in Polymers

Author: Charles E. Carraher Jr.

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 234

ISBN-13: 1468447483

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The first concern of scientists who are interested in synthetic polymers has always been, and still is: How are they synthesized? But right after this comes the question: What have I made, and for what is it good? This leads to the important topic of the structure-property relations to which this book is devoted. Polymers are very large and very complicated systems; their character ization has to begin with the chemical composition, configuration, and con formation of the individual molecule. The first chapter is devoted to this broad objective. The immediate physical consequences, discussed in the second chapter, form the basis for the physical nature of polymers: the supermolecular interactions and arrangements of the individual macromolecules. The third chapter deals with the important question: How are these chemical and physical structures experimentally determined? The existing methods for polymer characterization are enumerated and discussed in this chapter. The following chapters go into more detail. For most applications-textiles, films, molded or extruded objects of all kinds-the mechanical and the thermal behaviors of polymers are of pre ponderant importance, followed by optical and electric properties. Chapters 4 through 9 describe how such properties are rooted in and dependent on the chemical structure. More-detailed considerations are given to certain particularly important and critical properties such as the solubility and permeability of polymeric systems. Macromolecules are not always the final goal of the chemist-they may act as intermediates, reactants, or catalysts. This topic is presented in Chapters 10 and 11.


Cost Optimal and Nearly Zero-Energy Buildings (nZEB)

Cost Optimal and Nearly Zero-Energy Buildings (nZEB)

Author: Jarek Kurnitski

Publisher: Springer Science & Business Media

Published: 2013-11-20

Total Pages: 183

ISBN-13: 1447156102

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Cost optimal and nearly zero energy performance levels are principles initiated by the European Union’s (EU) Energy Performance of Buildings Directive which was recast in 2010. These will be major drivers in the construction sector in the next few years, because all new buildings in the EU from 2021 onwards are expected to be nearly zero energy buildings (nZEB). This book introduces the technical definitions, system boundaries, energy calculation methodology and input data needed to set primary energy based minimum/cost optimal and nZEB requirements in national energy frames. Worked examples are provided to illustrate the calculation of delivered, exported and primary energy, and renewable energy contribution. Five case studies of high performance nZEB office buildings across Europe are reported to show alternative technical solutions and to draw some general design rules based on completed nZEB buildings. Specific features of the nZEB design process, especially in the early stages, and architectural competitions are included. These describe important design issues in the scoping and conceptual design phase, allowing design streams to be controlled so that specified targets can be met. This book is intended for readers who need to be aware of or are working with the energy performance of buildings – for decision makers in public and private sectors, architects, engineers, construction clients, consultants, contractors, manufacturers and students. The editor of this book, Professor Jarek Kurnitski has made major contributions to the preparation of the European REHVA nZEB technical definition and has developed energy calculation frames for current Estonian and Finnish energy performance regulations. He is the leader of nZEB research at Tallinn University of Technology in Estonia and Aalto University in Finland, and he has over 300 publications.