Handbook of Biologically Active Peptides

Handbook of Biologically Active Peptides

Author: Abba Kastin

Publisher: Academic Press

Published: 2013-01-26

Total Pages: 2033

ISBN-13: 0123850967

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Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. - Presents all aspects of biologically active peptides in one resource - Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides - Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides - Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications


Handbook of Proteolytic Enzymes, Volume 1

Handbook of Proteolytic Enzymes, Volume 1

Author: Alan J. Barrett

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 1182

ISBN-13: 0080984150

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Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.


Fire under the Ashes

Fire under the Ashes

Author: John Donoghue

Publisher: University of Chicago Press

Published: 2013-11-15

Total Pages: 386

ISBN-13: 022607286X

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In Fire under the Ashes, John Donoghue recovers the lasting significance of the radical ideas of the English Revolution, exploring their wider Atlantic history through a case study of Coleman Street Ward, London. Located in the crowded center of seventeenth-century London, Coleman Street Ward was a hotbed of political, social, and religious unrest. There among diverse and contentious groups of puritans a tumultuous republican underground evolved as the political means to a more perfect Protestant Reformation. But while Coleman Street has long been recognized as a crucial location of the English Revolution, its importance to events across the Atlantic has yet to be explored. Prominent merchant revolutionaries from Coleman Street led England’s imperial expansion by investing deeply in the slave trade and projects of colonial conquest. Opposing them were other Coleman Street puritans, who having crossed and re-crossed the ocean as colonists and revolutionaries, circulated new ideas about the liberty of body and soul that they defined against England’s emergent, political economy of empire. These transatlantic radicals promoted social justice as the cornerstone of a republican liberty opposed to both political tyranny and economic slavery—and their efforts, Donoghue argues, provided the ideological foundations for the abolitionist movement that swept the Atlantic more than a century later.


The Levellers

The Levellers

Author: Rachel Foxley

Publisher: Manchester University Press

Published: 2016-05-16

Total Pages: 425

ISBN-13: 1526112086

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The Leveller movement of the 1640s campaigned for religious toleration and a radical remaking of politics in post-civil war England. This book, the first full-length study of the Levellers for fifty years, offers a fresh analysis of the originality and character of Leveller thought. Challenging received ideas about the Levellers as social contract theorists and Leveller thought as a mere radicalisation of parliamentarian thought, Foxley shows that the Levellers’ originality lay in their subtle and unexpected combination of different strands within parliamentarianism. The book takes full account of recent scholarship, and contributes to historical debates on the development of radical and republican politics in the civil war period, the nature of tolerationist thought, the significance of the Leveller movement and the extent of the Levellers’ influence in the ranks of the New Model Army.