Cats have come a long way from feral creatures to household pets. Learn about the historical journey these felines have traveled, including their status as sacred beings in ancient Egypt and their role as rodent hunters during the Middle Ages.
Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.
THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.
Sometimes feelings can go wild. . . Lily is a little girl with big emotions. And sometimes she can't keep herself from acting out and being naughty. Or rather, her imaginary friend, Tiger, is the naughty one. So when Tiger convinces her to run away, they have a blast stomping and jumping and going wild. But what is Lily to do when their adventure starts to feel a bit too wild? Tiger Wild gently illustrates how sometimes we all need a little help when certain feelings are hard to express. For there is a time to be wild and a time to be mild.
This smart new paperback guides women and men to the true pleasures of the under-explored seat of love. With Dr. Sadie’s trademark tongue-in-cheek narrative, together with dozens of tasteful illustrations, Tickle My Tush clearly shows how to enjoy these newfound thrills—comfortably, safely and pleasurably. Designed from mild-to-wild, backdoor-curious couples can easily find their personal approach and comfort levels--and at their own pace. From mild outercourse joys like sensual butt massage and gentle fingerplay, to wild orgasmic sensations of butt toys, innercourse and the table-turning thrills of “pegging”, they will feel confident with the tips and techniques that dispel fears and skyrocket pleasures. Tickle My Tush is the perfect companion for the one-third of American couples already engaging in analplay, and are interested in learning new knowledge and techniques that prevent discomfort and promote pleasure. It’s as equally inviting for anyone who’s curious about this adventure, but isn’t sure where to begin. THE PLEASURES YOU SEEK ARE RIGHT BEHIND YOU. Discover exciting new passions with the world’s most approachable “how-to” analplay guide. Stay mild–or go wild! Heat up with sensual butt massage, arouse with gentle fingerpadding, or take your buttplay adventures to the limit. Safeguard your health. Be confident with insider safer sex practices. Stay comfortable and protected – wherever your curiosities take you. Seeing is believing. Learn from over 60 tastefully explicit illustrations that show you the many exciting ways to give–and receive–with ease. Come from behind. Try all the touches and teases that unleash exhilarating climaxes–especially the proud ’n loud prostate orgasm! Double your pleasure. Discover the table-turning thrills of “pegging” and see why so many women—and men—are ecstatic. Go for ultimate arousal. Explore the erotic joys of fingerplay, tongue teases, penetration, butt toys, role reversal, and much more…. “If I’m gonna take advice from someone about my tush, it’s gonna be Dr. Sadie. Her style and humor are pleasant and informative, and she’s not afraid to leave out any embarrassing and important details. Remember...that’s where Cosmo gets its advice from!” -- ELENI SOLOMOU Columnist, Cosmopolitan “Whether you’re solo or with a partner—your fun, safe thrill-ride starts here.” -- CHARLIE GLICKMAN PH.D. Sexuality Educator & Writer “Dr. Sadie demystifies a taboo subject with humor, eloquence and a playful ease that leaves no vital information behind.” --EMILY MORSE Host Sex with Emily & Co-author Hot Sex Finally—a book that reveals all about anal sex in a way that’s simple and fun, reminding us that it’s really all about one thing: pleasure! -- DR. SANDOR GARDOS Licensed Clinical Psychologist & Sex Therapist Dr. Sadie is an exciting, alluring and thought-provoking artist. Each of her books never cease to move me to new heights, like a modern piece of art. --LAURA HENKEL PH.D. Erotic Art Appraiser & Founder Sin City Gallery From the bestselling author of Tickle His Pickle: Your Hands-on Guide to Penis Pleasing, Ride 'Em Cowgirl! Sex Position Secrets for Better Bucking, TOYGASMS! The Insiders Guide to Sex Toys and Techniques and Tickle Your Fancy: A Woman's Guide to Sexual Self-Pleasure.
Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.
From an outsider perspective learning about a sometimes misunderstood cultural pastime, a beautifully written and contrarian narrative about what it means to hunt in America today. When Lily Raff McCaulou traded in an indie film production career in New York for a reporting job in central Oregon, she never imagined that she'd find herself picking up a gun and learning to hunt. She'd been raised as a gun-fearing environmentalist and an animal lover, and though a meat-eater, she'd always abided by the principle that harming animals is wrong. But Raff McCaulou's perspective shifted when she began spending weekends fly-fishing and weekdays interviewing hunters for her articles, realizing that many of them were more thoughtful about animals and the environment than she was. So she embarked upon the project of learning to hunt from square one. From attending a Hunter Safety course designed for children to field dressing an elk and serving it for dinner, she explores the sport of hunting and all it entails, and tackles the big questions surrounding one of the most misunderstood American practices and pastimes. Not just a personal memoir, this book also explores the role of the hunter in the twenty-first century, the tension (at times artificial) between hunters and environmentalists, and new models of sustainable and ethical food procurement.
This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
The emergence of severe acute respiratory syndrome (SARS) in late 2002 and 2003 challenged the global public health community to confront a novel epidemic that spread rapidly from its origins in southern China until it had reached more than 25 other countries within a matter of months. In addition to the number of patients infected with the SARS virus, the disease had profound economic and political repercussions in many of the affected regions. Recent reports of isolated new SARS cases and a fear that the disease could reemerge and spread have put public health officials on high alert for any indications of possible new outbreaks. This report examines the response to SARS by public health systems in individual countries, the biology of the SARS coronavirus and related coronaviruses in animals, the economic and political fallout of the SARS epidemic, quarantine law and other public health measures that apply to combating infectious diseases, and the role of international organizations and scientific cooperation in halting the spread of SARS. The report provides an illuminating survey of findings from the epidemic, along with an assessment of what might be needed in order to contain any future outbreaks of SARS or other emerging infections.