Validamycin and Its Derivatives

Validamycin and Its Derivatives

Author: Xiaolong Chen

Publisher: Elsevier

Published: 2017-03-31

Total Pages: 342

ISBN-13: 008101113X

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Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications. - Offers complete coverage of validamycin chemistry from a highly experienced team of authors - Encourages the discovery of further novel drugs based on validamycin derivatives - Presents an interesting model for establishing new pharmaceutical leads from agricultural sources - Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines


Advances in Carbohydrate Chemistry and Biochemistry

Advances in Carbohydrate Chemistry and Biochemistry

Author:

Publisher: Academic Press

Published: 1991-01-28

Total Pages: 435

ISBN-13: 0080563074

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Intended for researchers in biochemistry, medicine, nutrition and industry, this book discusses such topics as components of bacterial polysaccharides, fluorinated carbohydrates, and carbon sugars chemistry.


Comprehensive Natural Products III

Comprehensive Natural Products III

Author:

Publisher: Elsevier

Published: 2020-07-22

Total Pages: 4266

ISBN-13: 0081026919

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Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience


Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

Author:

Publisher: Elsevier

Published: 2018-11-29

Total Pages: 542

ISBN-13: 0444641823

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Studies in Natural Products Chemistry, Volume 60 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores


Target Sites of Fungicide Action

Target Sites of Fungicide Action

Author: Wolfram Koeller

Publisher: CRC Press

Published: 2018-01-18

Total Pages: 350

ISBN-13: 1351093983

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Target Sites of Fungicide Action presents a critical examination of the mode of action of antifungal inhibitors, especially the mechanistical aspects of agricultural fungicides and antifungal drugs. It provides an interdisciplinary approach through its discussions of inhibitors with target sites in sterol biosynthesis, molecular studies in fungicide research, and fungal resistance. Researchers and students in plant pathology, mycology, and medicine will find this book to be a comprehensive summary of current knowledge, as well as a source of stimulation for future research in the field of applied mycology.


Carbohydrate Chemistry

Carbohydrate Chemistry

Author: N. R. Williams

Publisher: Royal Society of Chemistry

Published: 1982-05

Total Pages: 249

ISBN-13: 0851861229

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Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.


Biotechnology in China II

Biotechnology in China II

Author: G. T. Tsao

Publisher: Springer

Published: 2010-08-13

Total Pages: 276

ISBN-13: 3642149952

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Past, Present, and Future Industrial Biotechnology in China, by Zhenjiang Li, Xiaojun Ji, Suli Kan, Hongqun Qiao, Min Jiang, Dingqiang Lu, Jun Wang, He Huang, Honghua Jia, Pingkai Ouyuang, and Hanjie Ying.- Organic Chemicals from Bioprocesses in China, by Jin Huang, Lei Huang, Jianping Lin, Zhinan Xu, and Peilin Cen.- Biofuels in China, by Tianwei Tan, Jianliang Yu, Jike Lu, and Tao Zhang.- Bioreactors and Bioseparation, by Siliang Zhang, Xuejun Cao, Ju Chu, Jiangchao Qian, and Yingping Zhuang.- Environmental Biotechnology in China, by Shuang Jiang Liu , Lei Liu , Muhammad Tausif Chaudhry , Lei Wang , Ying Guang Chen , Qi Zhou , He Liu , and Jian Chen.- Traditional Chinese Biotechnology, by Yan Xu , Dong Wang , Wen Lai Fan , Xiao Qing Mu, and Jian Chen.- Modern Biotechnology in China, by Qing-Zhao Wang and Xue-Ming Zhao.


Carbohydrate Chemistry

Carbohydrate Chemistry

Author: Amelia Pilar Rauter

Publisher: Royal Society of Chemistry

Published: 2012-08-31

Total Pages: 461

ISBN-13: 1849734763

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In this volume, glycochemistry and glycobiology have been combined to demonstrate the contribution of organic chemistry, modern analytics, biological and biochemical expertise to the increasingly important field of glycomincs. A polysaccharide immunomodulator with therapeutic implications, carbohydrate vaccines, new findings emphasizing the influence of carbohydrate decoration on the regulation of inflammatory response and new therapeutic approaches in the treatment of acute and chronic inflammatory diseases, recent approachesin the treatment of acute and chronic inflammatory diseases, recent progress on glycoengineering based on a glycosylation, and key aspects of the glycosylation changes associated with bladder cancer are amongst the subjects presented in this volume. The contribution of glycochemistry to innovation in glycosciences is shown with chapters covering highly functionalized exo-glycals for the generation of molecular diversity in a chemoselective manner, imino sugar glycosidase inhibitors, carbasugars, multivalent glycoconjugates, including glycodendrimers, glyconanotubes, and glyconanoparticles, and their uses in medicinal chemistry, as well as artificial saccharide-based and saccharide functionalized gene delivery systems. Siderphores based on monosaccharides (which have proven effective for Gram-negative bacteria and mycobacteria), and the so-called smart materials, (which can modulate and control cell behaviour), complete the volume. Volume 38 of Carbohydrate Chemistry - Chemical and Biological Apporaches contains contributions ranging from glycochemistry to glycobiology. This collection demonstrates in a meaningful way how the interdisciplinary approach of an international glyconetwork can advance the field of carbohydrate research in Europe and worldwide.