Unravelling the Double Helix

Unravelling the Double Helix

Author: Gareth Williams

Publisher: Simon and Schuster

Published: 2019-10-01

Total Pages: 607

ISBN-13: 1643132830

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Unraveling the Double Helix covers the most colorful period in the history of DNA, from the discovery of "nuclein" in the late 1860s to the publication of James Watson's The Double Helix in 1968. These hundred years included the establishment of the Nobel Prize, antibiotics, x-ray crystallography, the atom bomb and two devastating world wars—events which are strung along the thread of DNA like beads on a necklace. The story of DNA is a saga packed with awful mistakes as well as brilliant science, with a wonderful cast of heroes and villains. Surprisingly, much of it is unfamiliar. The elucidation of the double helix was one of the most brilliant gems of twentieth century science, but some of the scientists who paved the way have been airbrushed out of history. James Watson and Francis Crick solved a magnificent mystery, but Gareth Williams shows that their contribution was the last few pieces of a gigantic jigsaw puzzle assembled over several decades.The book is comprehensive in scope, covering the first century of the history of DNA in its entirety, including the eight decades that have been neglected by other authors. It also explores the personalities of the main players, the impact of their entanglement with DNA, and what unique qualities make great scientists tick.


Francis Crick

Francis Crick

Author: Matt Ridley

Publisher: Harper Collins

Published: 2012-01-17

Total Pages: 228

ISBN-13: 0062200666

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Francis Crick—the quiet genius who led a revolution in biology by discovering, quite literally, the secret of life—will be bracketed with Galileo, Darwin, and Einstein as one of the greatest scientists of all time. In his fascinating biography of the scientific pioneer who uncovered the genetic code—the digital cipher at the heart of heredity that distinguishes living from non-living things—acclaimed bestselling science writer Matt Ridley traces Crick's life from middle-class mediocrity in the English Midlands through a lackluster education and six years designing magnetic mines for the Royal Navy to his leap into biology at the age of thirty-one and its astonishing consequences. In the process, Ridley sheds a brilliant light on the man who forever changed our world and how we understand it.


The Annotated and Illustrated Double Helix

The Annotated and Illustrated Double Helix

Author: James D. Watson

Publisher: Simon and Schuster

Published: 2012-11-06

Total Pages: 361

ISBN-13: 1476715513

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On the fiftieth anniversary of Watson and Crick receiving the Nobel Prize, a freshly annotated and illustrated edition of The Double Helix provides new insights into a scientific revolution. Published to mark the fiftieth anniversary of the Nobel Prize for Watson and Crick’s discovery of the structure of DNA, an annotated and illustrated edition of this classic book gives new insights into the personal relationships between James Watson, Frances Crick, Maurice Wilkins, and Rosalind Franklin, and the making of a scientific revolution.


Unraveling DNA

Unraveling DNA

Author: Maxim D. Frank-Kamenetskii

Publisher: Wiley

Published: 1993-07-19

Total Pages: 216

ISBN-13: 9780471188520

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... brilliant ... Yet anybody can understand it: it reads like a detective story.' John Maddox, Editor of Nature ' ... he skillfully imbues us with his joy and fascination with the living world, and the role of DNA in it.' Bruce M. Alberts, President of the National Academy of Sciences Unraveling DNA provides both laymen and scientist readers with a concise highly readable understanding of the structure, properties, and functions of the DNA molecule. The reader will find answers to all major questions about the biological, biotechnological, medical, physical, chemical, and mathematical aspects of DNA. In addition, the book includes an historical retrospective of past DNA research and forecasts future trends in the field. Written by an internationally acclaimed professor of biophysics as well as one of the world's leading authorities in DNA research, Unraveling DNA is designed to help professionals not specializing in molecular biology to understand the recent advances in this rapidly expanding field. The book is also especially useful to advanced high school students, junior college students, and university students interested in modern biology, medicine, physics, chemistry, and mathematics.


My Sister Rosalind Franklin

My Sister Rosalind Franklin

Author: Jenifer Glynn

Publisher: Oxford University Press, USA

Published: 2012-03-22

Total Pages: 187

ISBN-13: 0199699623

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A brief personal account by her sister, of Rosalind Franklin's family life.


Gene Machine

Gene Machine

Author: Venki Ramakrishnan

Publisher: Basic Books

Published: 2018-11-06

Total Pages: 290

ISBN-13: 046509337X

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A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule "Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end." -- Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome -- an enormous molecular machine made up of a million atoms -- that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.


Unravelling the Double Helix

Unravelling the Double Helix

Author: Gareth Williams

Publisher: Weidenfeld & Nicolson

Published: 2019-04-18

Total Pages: 500

ISBN-13: 1474609384

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DNA. The double helix; the blueprint of life; and, during the early 1950s, a baffling enigma that could win a Nobel Prize. Everyone knows that James Watson and Francis Crick discovered the double helix. In fact, they clicked into place the last piece of a huge jigsaw puzzle that other researchers had assembled over decades. Researchers like Maurice Wilkins (the 'Third Man of DNA') and Rosalind Franklin, famously demonised by Watson. Not forgetting the 'lost heroes' who fought to prove that DNA is the stuff of genes, only to be airbrushed out of history. In Unravelling the Double Helix, Professor Gareth Williams sets the record straight. He tells the story of DNA in the round, from its discovery in pus-soaked bandages in 1868 to the aftermath of Watson's best-seller The Double Helix a century later. You don't need to be a scientist to enjoy this book. It's a page-turner that unfolds like a detective story, with suspense, false leads and treachery, and a fabulous cast of noble heroes and back-stabbing villains. But beware: some of the science is dreadful, and the heroes and villains may not be the ones you expect.


DNA Systems Under Internal and External Forcing

DNA Systems Under Internal and External Forcing

Author: Megan Clare Engel

Publisher: Springer Nature

Published: 2019-09-17

Total Pages: 153

ISBN-13: 3030254135

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The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.


What Little I Remember

What Little I Remember

Author: Otto Robert Frisch

Publisher: Plunkett Lake Press

Published: 2019-08-17

Total Pages: 154

ISBN-13:

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Otto Robert Frisch took part in some of the most momentous developments in modern physics, notably the discovery of nuclear fission (a term which he coined). His work on the first atom bomb, which he saw explode in the desert “like the light of a thousand suns”, brought him into contact with figures such as Robert Oppenheimer, Edward Teller, Richard Feynman and the father of electronic computers, John von Neumann. He also encountered the physicists who had made the great discoveries of recent generations: Einstein, Rutherford and Niels Bohr. This characterful book of reminiscences sheds an engagingly personal light on the people and events behind some of the greatest scientific discoveries of this century, illustrated with a series of fascinating photographs and witty sketches by the author himself. “This is a happy book, from which the author's personality and his enjoyment of physics, of music, of life, emerges clearly. It is also a portrait of the pre-War world of physics, of days of small numbers and small apparatus, of times when a physicist could think of an ingenious experiment today and set it up tomorrow.” — Rudolf Peierls, Nature “In writing a charming, light-hearted cameo of his life and times as a scientist, Professor Frisch has revealed more about science than many authors with greater pretensions. This is a book that deserves to be read, and will be enjoyed, by a wide audience.” — The Economist “Despite his modest title, what Frisch ‘manages to remember’ is quite impressive. He loved to tell stories and his many vignettes of his associates... include nearly every outstanding physicist who worked in nuclear physics.” — Science “In the straightforward narrative style he developed writing lay treatments of modern physics, Frisch recounts his memories of significant men and events in the history of physics between 1920 and 1960... Frisch tells his stories well...” — Robert W. Seidel,Isis, A Journal of the History of Science Society


Understanding DNA

Understanding DNA

Author: Chris R. Calladine

Publisher: Elsevier

Published: 2004-03-13

Total Pages: 349

ISBN-13: 0080474667

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The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth. The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA. - Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix - Outlines the methods used to study DNA structure - Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension