Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine
Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

Author: Ana Colette Maurício

Publisher: BoD – Books on Demand

Published: 2017-01-11

Total Pages: 260

ISBN-13: 9535128655

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Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Umbilical Cord Blood Banking and Transplantation
Umbilical Cord Blood Banking and Transplantation

Author: Karen Ballen

Publisher: Springer

Published: 2014-08-12

Total Pages: 290

ISBN-13: 3319064444

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This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

Cord Blood Stem Cells Medicine
Cord Blood Stem Cells Medicine

Author: Catherine Stavropoulos-Giokas

Publisher: Elsevier

Published: 2014-12-03

Total Pages: 399

ISBN-13: 0124078362

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Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. - Comprehensive coverage of the medical application of cord blood stem cells - Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine - Covers new applications of cord blood stem cells, particularly transplantation and HIV - Introduces new technologies for cord blood stem cells and regenerative medicine

Regenerative Medicine Using Pregnancy-Specific Biological Substances
Regenerative Medicine Using Pregnancy-Specific Biological Substances

Author: Niranjan Bhattacharya

Publisher: Springer Science & Business Media

Published: 2010-12-25

Total Pages: 455

ISBN-13: 1848827180

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The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.

Stem Cell Banking
Stem Cell Banking

Author: Dusko Ilic

Publisher: Springer

Published: 2014-05-05

Total Pages: 175

ISBN-13: 1493905856

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This book exemplifies experience across the globe in banking of cord blood, mesenchymal, embryonic and induced pluripotent stem cells for clinical use from the United States, Canada, the European Union, Switzerland and Japan to Iran, India and Serbia. The concerns are similar regardless of stem cell type or origin. Implementing core values and common standards depend often on specific circumstances of political and economic setting, which makes flexibility as important as systematic planning. Banking of stem cells is not just building a repository and storing samples. The planning, design, construction and maintenance involve multiple skilled professionals. Stem cell banks are points where technology and medicine converge with ethics, laws and regulations. If properly designed and organized, their utilization will have a broad impact not only on the scientific community and medical professionals but also on the general public.

Cord Blood
Cord Blood

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2005-11-26

Total Pages: 335

ISBN-13: 0309095867

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With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.

Perinatal Stem Cells
Perinatal Stem Cells

Author: Anthony Atala

Publisher: Academic Press

Published: 2018-06-14

Total Pages: 438

ISBN-13: 0128120630

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Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Cord Blood
Cord Blood

Author: Lisandra Vanostrand

Publisher: Nova Science Publishers

Published: 2013

Total Pages: 0

ISBN-13: 9781626180727

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In this book, the authors discuss cord blood banks and banking, the ethical issues involved and the risks and benefits. Topics include the virological risks and benefits of cord blood banking; mesenchymal stem cells and their role in regenerative medicine applications; osteogenic potential of human umbilical cord-derived mesenchymal stromal cells; public versus private cord blood banking; CCR5 deficient cord blood as a means of treatment for HIV-1 infection; and the therapeutic use of umbilical cord blood.

Perinatal Stem Cells
Perinatal Stem Cells

Author: Kyle Cetrulo

Publisher: John Wiley & Sons

Published: 2013-02-04

Total Pages: 438

ISBN-13: 1118497945

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Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers. Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry. With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.