Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.


Heat Transfer and Fluid Flow in Biological Processes

Heat Transfer and Fluid Flow in Biological Processes

Author: Sid M. Becker

Publisher: Academic Press

Published: 2014-12-31

Total Pages: 428

ISBN-13: 0124079008

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Heat Transfer and Fluid Flow in Biological Processes covers emerging areas in fluid flow and heat transfer relevant to biosystems and medical technology. This book uses an interdisciplinary approach to provide a comprehensive prospective on biofluid mechanics and heat transfer advances and includes reviews of the most recent methods in modeling of flows in biological media, such as CFD. Written by internationally recognized researchers in the field, each chapter provides a strong introductory section that is useful to both readers currently in the field and readers interested in learning more about these areas. Heat Transfer and Fluid Flow in Biological Processes is an indispensable reference for professors, graduate students, professionals, and clinical researchers in the fields of biology, biomedical engineering, chemistry and medicine working on applications of fluid flow, heat transfer, and transport phenomena in biomedical technology. - Provides a wide range of biological and clinical applications of fluid flow and heat transfer in biomedical technology - Covers topics such as electrokinetic transport, electroporation of cells and tissue dialysis, inert solute transport (insulin), thermal ablation of cancerous tissue, respiratory therapies, and associated medical technologies - Reviews the most recent advances in modeling techniques


Interactive Phenomena in the Cardiac System

Interactive Phenomena in the Cardiac System

Author: S. Sideman

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 417

ISBN-13: 1461529468

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The cardiac system represents one of the most exciting challenges to human ingenuity. Critical to our survival, it consists of a tantalizing array of interacting phenomena, from ionic transport, membrane channels and receptors through cellular metabolism, energy production to fiber mechanics, microcirculation, electrical activation to the global, clinically observed, function, which is measured by pressure, volume, coronary flow, heart rate, shape changes and responds to imposed loads and pharmaceutical challenges. It is a complex interdisciplinary system requiring the joint efforts of the life sciences, the exact sciences, engineering and technology to understand and control the pathologies involved. The Henry Goldberg Workshops were set up to address these multivariable, multidisciplinary challenges. Briefly, our goals are: To encourage international cooperation and foster interdisciplinary interaction between scientists from the different areas of cardiology; to relate microscale cellular phenomena to the global, clinically manifested cardiac function; to relate conceptual modeling and quantitative analysis to experimental and clinical data; to gain an integrated view of the various interacting parameters, identify missing links, catalyze new questions, and lead to better understanding of the cardiac system. The outstanding success of past workshops has encouraged their continuation. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between mechanics, electrical activation, perfusion and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects.


Tumor Blood Circulation

Tumor Blood Circulation

Author: Hans-Inge Peterson

Publisher: CRC Press

Published: 2020-04-15

Total Pages: 238

ISBN-13: 1000087042

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First Published in 1979, this book offers a full, insight into the relationship between malignant tumors and blood flow. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.


Transport Phenomena in Biological Systems

Transport Phenomena in Biological Systems

Author: George A. Truskey

Publisher: Prentice Hall

Published: 2009

Total Pages: 889

ISBN-13: 0131569880

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For one-semester, advanced undergraduate/graduate courses in Biotransport Engineering. Presenting engineering fundamentals and biological applications in a unified way, this text provides students with the skills necessary to develop and critically analyze models of biological transport and reaction processes. It covers topics in fluid mechanics, mass transport, and biochemical interactions, with engineering concepts motivated by specific biological problems.


Mechanisms of Vascular Disease

Mechanisms of Vascular Disease

Author: Robert Fitridge

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 589

ISBN-13: 1922064009

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New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.


Cardiovascular Fluid Mechanics

Cardiovascular Fluid Mechanics

Author: Gianni Pedrizzetti

Publisher: Springer

Published: 2014-05-04

Total Pages: 277

ISBN-13: 3709125421

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The book presents the state of the art in the interdisciplinary field of fluid mechanics applied to cardiovascular modelling. It is neither a monograph nor a collection of research papers, rather an extended review in the field. It is arranged in 4 scientific chapters each presenting thoroughly the approach of a leading research team; two additional chapters prepared by biomedical scientists present the topic by the applied perspective. A unique feature is a substantial (approx. one fourth of the book) medical introductory part, written by clinical researchers for scientific readers, that would require a large effort to be collected otherwise.


Biofluid Mechanics

Biofluid Mechanics

Author: Wei Yin

Publisher: Academic Press

Published: 2011-11-02

Total Pages: 411

ISBN-13: 0123813840

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Both broad and deep in coverage, Rubenstein shows that fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement and renal transport. Each section initiates discussion with governing equations, derives the state equations and then shows examples of their usage. Clinical applications, extensive worked examples, and numerous end of chapter problems clearly show the applications of fluid mechanics to biomedical engineering situations. A section on experimental techniques provides a springboard for future research efforts in the subject area. - Uses language and math that is appropriate and conducive for undergraduate learning, containing many worked examples and end of chapter problems - All engineering concepts and equations are developed within a biological context - Covers topics in the traditional biofluids curriculum, as well as addressing other systems in the body that can be described by biofluid mechanics principles, such as air flow through the lungs, joint lubrication, intraocular fluid movement, and renal transport - Clinical applications are discussed throughout the book, providing practical applications for the concepts discussed.


Transport Phenomena in Biomedical Engineering

Transport Phenomena in Biomedical Engineering

Author: Robert A. Peattie

Publisher: CRC Press

Published: 2012-11-20

Total Pages: 205

ISBN-13: 143987462X

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Design, analysis and simulation of tissue constructs is an integral part of the ever-evolving field of biomedical engineering. The study of reaction kinetics, particularly when coupled with complex physical phenomena such as the transport of heat, mass and momentum, is required to determine or predict performance of biologically-based systems whether for research or clinical implementation. Transport Phenomena in Biomedical Engineering: Principles and Practices explores the concepts of transport phenomena alongside chemical reaction kinetics and thermodynamics to introduce the field of reaction engineering as it applies to physiologic systems in health and disease. It emphasizes the role played by these fundamental physical processes. The book first examines elementary concepts such as control volume selection and flow systems. It provides a comprehensive treatment with an overview of major research topics related to transport phenomena pertaining to biomedical engineering. Although each chapter is self-contained, they all bring forth and reinforce similar concepts through applications and discussions. With contributions from world-class experts, the book unmasks the fundamental phenomenological events in engineering devices and explores how to use them to meet the objectives of specific applications. It includes coverage of applications to drug delivery and cell- and tissue-based therapies.