Transition States of Biochemical Processes

Transition States of Biochemical Processes

Author: R. Gandour

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 625

ISBN-13: 1468499785

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The transItIOn-state theory has been, from the point of its inception, the most influential principle in the development of our knowledge of reaction mechanisms in solution. It is natural that as the field of biochemical dynamics has achieved new levels of refinement its students have increasingly adopted the concepts and methods of transition-state theory. Indeed, every dynamical problem of biochemistry finds its most elegant and economical statement in the terms of this theory. Enzyme catalytic power, for example, derives from the interaction of enzyme and substrate structures in the transition state, so that an understanding of this power must grow from a knowledge of these structures and interactions. Similarly, transition-state interactions, and the way in which they change as protein structure is altered, constitute the pivotal feature upon which molecular evolution must turn. The complete, coupled dynamical system of the organism, incorporating the transport of matter and energy as well as local chemical processes, will eventually have to yield to a description of its component transition-state structures and their energetic response characteristics, even if the form of the description goes beyond present-day transition-state theory. Finally, the importance of biochemical effectors in medicine and agriculture carries the subject into the world of practical affairs, in the use of transition-state information for the construction of ultra potent biological agents.


Transition State

Transition State

Author: Takayuki Fueno

Publisher: CRC Press

Published: 2019-08-16

Total Pages: 328

ISBN-13: 100071747X

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The transition state is the critical configuration of a reaction system situated at the highest point of the most favorable reaction path on the potential-energy surface, its characteristics governing the dynamic behavior of reacting systems decisively. This text presents an accurate survey of current theoretical investigations of chemical reactions, with a focus on the nature of the transition state. Its scope ranges from general basic theories associated with the transition states, to their computer-assisted applications, through to a number of reactions in a state-of-the-art fashion. It covers various types of gas-phase elementary reactions, as well as some specific types of chemical processes taking place in the liquid phase. Also investigated is the recently developing transition state spectroscopy. This text will not only serve as a contemporary reference book on the concept of the transition state, but will also assist the readers in gaining valuable key principles regarding the essence of chemical kinetics and dynamics.


Transition State

Transition State

Author: Takayuki Fueno

Publisher: CRC Press

Published: 2019-08-16

Total Pages: 348

ISBN-13: 1000725294

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The transition state is the critical configuration of a reaction system situated at the highest point of the most favorable reaction path on the potential-energy surface, its characteristics governing the dynamic behavior of reacting systems decisively. This text presents an accurate survey of current theoretical investigations of chemical reactions, with a focus on the nature of the transition state. Its scope ranges from general basic theories associated with the transition states, to their computer-assisted applications, through to a number of reactions in a state-of-the-art fashion. It covers various types of gas-phase elementary reactions, as well as some specific types of chemical processes taking place in the liquid phase. Also investigated is the recently developing transition state spectroscopy. This text will not only serve as a contemporary reference book on the concept of the transition state, but will also assist the readers in gaining valuable key principles regarding the essence of chemical kinetics and dynamics.


Solid States

Solid States

Author: Michael Bell

Publisher: Princeton Architectural Press

Published: 2010-12

Total Pages: 288

ISBN-13: 9781568988955

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DVD features highlights from the conference held at Columbia University.


Reaction Rate Theory and Rare Events

Reaction Rate Theory and Rare Events

Author: Baron Peters

Publisher: Elsevier

Published: 2017-03-22

Total Pages: 636

ISBN-13: 0444594701

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Reaction Rate Theory and Rare Events bridges the historical gap between these subjects because the increasingly multidisciplinary nature of scientific research often requires an understanding of both reaction rate theory and the theory of other rare events. The book discusses collision theory, transition state theory, RRKM theory, catalysis, diffusion limited kinetics, mean first passage times, Kramers theory, Grote-Hynes theory, transition path theory, non-adiabatic reactions, electron transfer, and topics from reaction network analysis. It is an essential reference for students, professors and scientists who use reaction rate theory or the theory of rare events. In addition, the book discusses transition state search algorithms, tunneling corrections, transmission coefficients, microkinetic models, kinetic Monte Carlo, transition path sampling, and importance sampling methods. The unified treatment in this book explains why chemical reactions and other rare events, while having many common theoretical foundations, often require very different computational modeling strategies. - Offers an integrated approach to all simulation theories and reaction network analysis, a unique approach not found elsewhere - Gives algorithms in pseudocode for using molecular simulation and computational chemistry methods in studies of rare events - Uses graphics and explicit examples to explain concepts - Includes problem sets developed and tested in a course range from pen-and-paper theoretical problems, to computational exercises


The Welfare State in Transition

The Welfare State in Transition

Author: Richard B. Freeman

Publisher: University of Chicago Press

Published: 2008-04-15

Total Pages: 490

ISBN-13: 0226261859

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Once heralded in the 1950s and 1960s as a model welfare state, Sweden is now in transition and in trouble since its economic plunge in the early 1990s. This volume presents ten essays that examine Sweden's economic problems from a U.S. perspective. Exploring such diverse topics as income equalization and efficiency, welfare and tax policy, wage determination and unemployment, and international competitiveness and growth, they consider how Sweden's welfare state succeeded in eliminating poverty and became a role model for other countries. They then reflect on Sweden's past economic problems, such as the increase in government spending and the fall in industrial productivity, warning of problems to come. Finally they review the consequences of the collapse of Sweden's economy in the early 1990s, exploring the implications of its efforts to reform its welfare state and reestablish a healthy economy. This volume will be of interest to policymakers and analysts, social scientists, and economists interested in welfare states.


Physics of Transition Metal Oxides

Physics of Transition Metal Oxides

Author: Sadamichi Maekawa

Publisher: Springer Science & Business Media

Published: 2004-06-22

Total Pages: 356

ISBN-13: 9783540212935

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The fact that magnetite (Fe304) was already known in the Greek era as a peculiar mineral is indicative of the long history of transition metal oxides as useful materials. The discovery of high-temperature superconductivity in 1986 has renewed interest in transition metal oxides. High-temperature su perconductors are all cuprates. Why is it? To answer to this question, we must understand the electronic states in the cuprates. Transition metal oxides are also familiar as magnets. They might be found stuck on the door of your kitchen refrigerator. Magnetic materials are valuable not only as magnets but as electronics materials. Manganites have received special attention recently because of their extremely large magnetoresistance, an effect so large that it is called colossal magnetoresistance (CMR). What is the difference between high-temperature superconducting cuprates and CMR manganites? Elements with incomplete d shells in the periodic table are called tran sition elements. Among them, the following eight elements with the atomic numbers from 22 to 29, i. e. , Ti, V, Cr, Mn, Fe, Co, Ni and Cu are the most im portant. These elements make compounds with oxygen and present a variety of properties. High-temperature superconductivity and CMR are examples. Most of the textbooks on magnetism discuss the magnetic properties of transition metal oxides. However, when one studies magnetism using tradi tional textbooks, one finds that the transport properties are not introduced in the initial stages.


Advances in Physical Organic Chemistry

Advances in Physical Organic Chemistry

Author: John P. Richard

Publisher: Academic Press

Published: 2006-12-07

Total Pages: 411

ISBN-13: 0120335417

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Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics. Reviews the application of quantitative and mathematical methods towards understanding chemical problems Multidisciplinary volumes cover organic, organometallic, bioorganic, enzymes and materials topics


Advances in Carbohydrate Chemistry and Biochemistry

Advances in Carbohydrate Chemistry and Biochemistry

Author:

Publisher: Academic Press

Published: 2014-12-02

Total Pages: 505

ISBN-13: 0128008059

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Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. - Features contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field