Toxicology and Human Environments

Toxicology and Human Environments

Author: Ernest Hodgson

Publisher: Academic Press

Published: 2012-09-28

Total Pages: 452

ISBN-13: 0124158137

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Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them


Human Toxicology of Chemical Mixtures

Human Toxicology of Chemical Mixtures

Author: Harold Zeliger

Publisher: William Andrew

Published: 2011-06-24

Total Pages: 575

ISBN-13: 1437734642

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In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. - Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations – far too many to comprehensively catalog) - A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists - New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures


Environmental Toxicants

Environmental Toxicants

Author: Morton Lippmann

Publisher: John Wiley & Sons

Published: 2009-03-26

Total Pages: 1189

ISBN-13: 0470442883

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Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles


Toxicology and Environmental Health Information Resources

Toxicology and Environmental Health Information Resources

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1997-02-10

Total Pages: 172

ISBN-13: 0309175011

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The environment is increasingly recognized as having a powerful effect on human and ecological health, as well as on specific types of human morbidity, mortality, and disability. While the public relies heavily on federal and state regulatory agencies for protection from exposures to hazardous substances, it often looks to health professionals for information about routes of exposure and the nature and extent of associated adverse health consequences. However, most health professionals acquire only a minimal knowledge of toxicology during their education and training. In 1967 the National Library of Medicine (NLM) created an information resource, known today as the Toxicology and Environmental Health Information Program (TEHIP). In 1995 the NLM asked the Institute of Medicine to examine the accessiblity and utility of the TEHIP databases for the work of health professionals. This resulting volume contains chapters on TEHIP and other toxicology and environmental health databases, on understanding the toxicology and environmental health information needs of health professionals, on increasing awareness of information resources through training and outreach, on accessing and navigating the TEHIP databases, and on program issues and future directions.


Human Biomonitoring for Environmental Chemicals

Human Biomonitoring for Environmental Chemicals

Author: National Research Council

Publisher: National Academies Press

Published: 2006-11-30

Total Pages: 317

ISBN-13: 0309102723

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Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.


Ecosystems and Human Health

Ecosystems and Human Health

Author: Richard B. Philp

Publisher: CRC Press

Published: 2013-03-27

Total Pages: 441

ISBN-13: 146656721X

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Since the second edition of this text was published, many new environmental incidents have occurred, including another nuclear disaster, a mine disaster in the United States, and the Gulf of Mexico oil spill. Updated throughout the text, Ecosystems and Human Health: Toxicology and Environmental Hazards, Third Edition explores the broad range of environmental and human health aspects of chemical and biological hazards—from natural toxins and disasters to man-made pollutants and environmental crises. The book begins with the basic principles of pharmacology and toxicology, risk analysis, and air, water, and soil pollution. It then examines various toxicants and hazards, such as airborne hazards, halogenated hydrocarbons, metals, and organic solvents. Chapters also discuss food additives and contaminants, pesticides, hormone disrupters, radiation hazards, and natural environmental hazards such as venomous and toxic animals. The text reviews the Chernobyl nuclear crisis and the Walkerton drinking water tragedy, as well as other disasters, assessing some of their long-term effects, now that sufficient time has elapsed since their occurrence. With updates in every chapter, this third edition contains significant expansion of information on the genetics of chemical carcinogenesis, global warming, food additives, invasive species in the Great Lakes, nuclear accidents, and more. The book describes how chemical toxins and biological hazards can impact the environment and the people who live in it. The author presents numerous examples of the relationship between ecosystem health and human health. He emphasizes the need to consider the environmental impact of human activities and includes many real-world examples and new case studies.


Systems Biology in Toxicology and Environmental Health

Systems Biology in Toxicology and Environmental Health

Author: Rebecca Fry

Publisher: Academic Press

Published: 2015-06-11

Total Pages: 285

ISBN-13: 0128015683

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Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. - Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology - Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology - Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them


Molecular, Clinical and Environmental Toxicology

Molecular, Clinical and Environmental Toxicology

Author: Andreas Luch

Publisher: Springer Science & Business Media

Published: 2010-03-01

Total Pages: 620

ISBN-13: 3764383380

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Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.


Basic Environmental Toxicology

Basic Environmental Toxicology

Author: Lorris G. Cockerham

Publisher: Routledge

Published: 2019-07-05

Total Pages: 640

ISBN-13: 1351464639

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Basic Environmental Toxicology provides a thorough, systematic introduction to environmental toxicology and addresses many of the effects of pollutants on humans, animals, and the environment. Readers are introduced to the fundamentals of toxicology and ecotoxicology, the effects of different types of toxicants, and how toxicants affect different compartments of the environment. Fundamental aspects of environmental health, occupational health, detection of pollutants, and risk assessment are discussed. The book is excellent for anyone involved in risk assessment or risk management, toxicologists, state and local public health officials, environmental engineers, industrial managers, consultants, and students taking environmental toxicology courses.


Environmental Epigenetics in Toxicology and Public Health

Environmental Epigenetics in Toxicology and Public Health

Author: Rebecca Fry

Publisher: Academic Press

Published: 2020-11-04

Total Pages: 366

ISBN-13: 0128199687

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Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification Features contributions from international experts in the field