Science and Judgment in Risk Assessment
Science and Judgment in Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 1994-01-01

Total Pages: 668

ISBN-13: 030904894X

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The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

Toxicology and Risk Assessment
Toxicology and Risk Assessment

Author: Helmut Greim

Publisher: John Wiley & Sons

Published: 2018-11-05

Total Pages: 838

ISBN-13: 1119135915

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Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Pesticide Toxicity to Non-target Organisms
Pesticide Toxicity to Non-target Organisms

Author: Johnson Stanley

Publisher: Springer

Published: 2016-08-12

Total Pages: 531

ISBN-13: 9401777527

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The pesticide should cause effect on the target pests and be selective enough to spare the non-target beneficial. The book deals with the pesticide toxicity to predators, parasitoids and microbes which are used for pest management in the agroecosystem. The other beneficials exposed to pesticides are pollinators, earthworms, silkworm and fishes. The book contains information on the modes of pesticide exposure and toxicity to the organisms, sub-lethal effects of insecticides and method of toxicity assessment, risk assessment of pesticidal application in the field. The purpose of the work is to compile and present the different procedures to assess pesticide poising in organisms related to the agroecosystem along with discussions on risk assessment procedures with clear comparison of toxicity of pesticides to target pests and non target beneficial organisms.

Toxicity and Risk
Toxicity and Risk

Author: H Paul A Illing

Publisher: CRC Press

Published: 2001-09-20

Total Pages: 165

ISBN-13: 020346804X

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Humans are constantly, and increasingly, exposed to chemicals - some naturally occurring and some manufactured. Exposure to some of these chemicals, or to large amounts of them, can bring risks to human health and the environment. Toxicity and Risk sets out the political, social, legal and scientific basis of risk assessment and risk management. Ta

Toxicological Risk Assessment of Chemicals
Toxicological Risk Assessment of Chemicals

Author: Elsa Nielsen

Publisher: CRC Press

Published: 2008-02-21

Total Pages: 450

ISBN-13: 1420006940

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Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 2007-12-19

Total Pages: 300

ISBN-13: 0309112982

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The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Toxicity-Pathway-Based Risk Assessment
Toxicity-Pathway-Based Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 2010-06-07

Total Pages: 135

ISBN-13: 0309156920

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In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

Science and Decisions
Science and Decisions

Author: National Research Council

Publisher: National Academies Press

Published: 2009-03-24

Total Pages: 422

ISBN-13: 0309120462

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Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Toxicology and Risk Assessment
Toxicology and Risk Assessment

Author: Anna M. Fan

Publisher: CRC Press

Published: 2015-03-04

Total Pages: 1414

ISBN-13: 9814613398

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The presence of chemicals in our environment is a subject of intense interest owing to the many potential adverse health effects to humans following exposure to these chemicals. The principles and practices of risk assessment are used to assess the associated health risks to provide a scientific and health basis for guidance or regulatory standards