Asbestiform Fibers

Asbestiform Fibers

Author: Committee on Nonoccupational Health Risks of Asbestiform Fibers

Publisher:

Published: 1984

Total Pages: 356

ISBN-13:

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Much of the more than 30 million tons of asbestos used in the United States since 1900 is still present as insulation in offices and schools, as vinyl-asbestos flooring in homes, and in other common products. This volume presents a comprehensive evaluation of the relation of these fibers to specific diseases and the extent of nonoccupational risks associated with them. It covers sources of asbestiform fibers, properties of the fibers, and carcinogenic and fibrogenic risks they pose.


Mineral Fibers and Health

Mineral Fibers and Health

Author: F.D.K. Liddell

Publisher: CRC Press

Published: 1991-06-04

Total Pages: 398

ISBN-13: 9780849366468

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The part of this book covering pathogensis and modes of action begins with a chapter on the physicochemical properties of asbestos fibers and a chapter on the deposition and retention of fibers within the lung and their clearance. Some of the effects of asbestos can be reproduced in animal experiments, and the book includes a full review of the results from animal studies using various routes of administration of fibers. It is also generally accepted that the effects of fibers on pulmonary macrophages is central to all fiber-induced pathology, and the release of macrophage-associated inflammatory and immunological mediatros is dealt with in a further chapter. Examination of pathogenicity by cell culture is described, and areas covered include the role of free radicals and cellular mechanisms in producing genetic damage. The fiber-induced activation of some second messenger pathways is also described, with consideration of whether or not similar cellular mechanisms are responsible for all the clinical conditions associated with fiber exposure. Knowledge of the mechanisms involved should be valuable in the development of safe fibers and the prevention of human exposure to new materials that are dangerous as asbestos. The final chapters expound and resolve the conflicts in evidence, discuss the importance of fibers for human well-being and the possible health impact on nonmineral alternatives, and evaluate risks to the public


Review of the U.S. Navy's Exposure Standard for Manufactured Vitreous Fibers

Review of the U.S. Navy's Exposure Standard for Manufactured Vitreous Fibers

Author: National Research Council

Publisher: National Academies Press

Published: 2000-09-07

Total Pages: 92

ISBN-13: 0309070937

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Manufactured vitreous fibers (MVF), also known as synthetic vitreous fibers, are considered to be less hazardous than asbestos to human health. They are used in many thermal- and acoustical-insulation applications as an asbestos substitute or as a filtration medium. The Navy uses MVF in shipboard and onshore applications. To protect Navy personnel from harmful exposures to MVF, the U.S. Navy Environmental Health Center (NEHC) developed occupational exposure standards. The documentation assists industrial hygienists, occupational medicine physicians, and other Navy health professionals in assessing and controlling the health hazards linked with exposure to MVF. In 1997, the National Research Council (NRC) was asked to conduct an independent review of the Navy's toxicological assessment of MVF and to evaluate the scientific validity of its exposure standard of 2 fibers per cubic centimeter of air (f/cm3). The NRC assigned the task to the Committee on Toxicology, which established the Subcommittee on Manufactured Vitreous Fibers, a multidisciplinary group of experts, to determine whether all relevant toxicological and epidemiological data were correctly considered in developing the exposure standard; and to examine the uncertainty, variability, and quality of data and the appropriateness of assumptions used in the derivation of the exposure standard. The subcommittee was also asked to identify deficiencies in the MVF database and, where appropriate, to make recommendations for future research and data development. Review of the U.S. Navy's exposure Standard for Manufactured Vitreous Fibers represents the subcommittee's final report. The committee had expanded its review when in January 1999, the Navy revised its Occupational Safety and Health Program Manual (CNO 1999), changing the occupational exposure limit for MVF to the American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value (TLV) of 1 f/cm3. The report features recommendations by the subcommittee as well as information gaps found throughout investigation. Overall, the subcommittee found that the Navy made a good start in assessing the health effects of MVF, but needed further research.


Toxic and Hazardous Materials

Toxic and Hazardous Materials

Author: James K. Webster

Publisher: Greenwood

Published: 1987-01-13

Total Pages: 456

ISBN-13:

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A bibliography of material on hazardous materials and directory of organizations and other producers of further information.


Biological Effects of Fibrous and Particulate Substances

Biological Effects of Fibrous and Particulate Substances

Author: Takemi Otsuki

Publisher: Springer

Published: 2015-09-28

Total Pages: 229

ISBN-13: 4431557326

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This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles. It offers comprehensive information on the latest insights into the immunological effects of various irritants on the human body. Readers will benefit from the contributing authors’ diverse perspectives and extensive discussions of key issues, which include molecular alterations of the immune system and autoimmune diseases in connection with asbestos and silica, among others. The chapters also discuss recommendations, practical methods, and nanosafety science in situations involving exposure to nanotoxic substances. Edited in collaboration with the Japanese Society for Hygiene, this book provides up-to-date information on the immunological effects of nanotoxic substances to researchers interested in environmental and occupational health. Presenting a number of recent concepts and findings in the field, it enables readers to gain a comprehensive knowledge of health problems caused by environmental fibrous and particulate substances.