Topical Applications and the Mucosa
Topical Applications and the Mucosa

Author: C. Surber

Publisher: Karger Medical and Scientific Publishers

Published: 2011-02-10

Total Pages: 174

ISBN-13: 3805596162

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Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed.Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.

Topical Applications and the Mucosa
Topical Applications and the Mucosa

Author: Christian Surber

Publisher: Karger Medical and Scientific Publishers

Published: 2011

Total Pages: 174

ISBN-13: 3805596154

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An excellent summary and review Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed. Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.

Dermatology Made Easy
Dermatology Made Easy

Author: Amanda Oakley

Publisher: Scion Publishing Ltd

Published: 2017-05-06

Total Pages: 438

ISBN-13: 1911510118

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A concise overview of the common dermatological conditions most likely to present in general medicine From reviews: "... a perfect solution to the constant struggle that dermatology diagnosis presents to primary care physicians and other providers... This well-formatted book covers a vast array of topics ranging from common to rare skin disorders. The pictures are immensely helpful in the understanding of various skin rashes...." Fam Med 2019;51(5):451–452. “... easy to read and informative. One cannot emphasise enough the quality and comprehensive nature of the photographic content.... As someone who was interested in dermatology even as a medical student my only regret is that this book was not around when I was a student as it would have very adequately guided me into my beloved subspecialty.” Ulster Med J 2017;86(3):1–1. “The introduction outlines dermatological conditions by symptom, morphology and body site, providing an excellent index prior to delving into greater detail in the following chapters. The logical approach and level of detail make this text perfect for medical students, interns/residents, primary care physicians and other specialists who wish to quickly identify differential diagnoses or refresh their knowledge of dermatological conditions.” A Lecturer in Dermatology Dermatology Made Easy is based on the hugely popular DermNet New Zealand website and is designed to help GPs, medical students and dermatologists diagnose skin conditions with confidence. The book starts by providing a series of comprehensive tables, complete with over 500 thumbnail photos, to aid diagnosis according to symptoms, morphology, or body site. Once you have narrowed down the diagnosis, cross-references then guide you to more detailed descriptions, and another 700 photographs, covering: common infections inflammatory rashes non-inflammatory conditions skin lesions Every section provides consistent information on the disorder: who gets it and what causes it? what are the clinical features and does it cause any complications? how do you diagnose it? how do you treat it and how long does it take to resolve? The book concludes with a comprehensive section on further investigations and treatment options. Dermatology Made Easy combines the essential focus of the Made Easy book series with the authority and knowledge base of DermNet New Zealand’s unparalleled resources. Printed in full colour throughout.

Bioadhesives in Drug Delivery
Bioadhesives in Drug Delivery

Author: K. L. Mittal

Publisher: John Wiley & Sons

Published: 2020-05-12

Total Pages: 432

ISBN-13: 1119640253

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Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Polymeric Gels
Polymeric Gels

Author: Kunal Pal

Publisher: Woodhead Publishing

Published: 2018-06-15

Total Pages: 570

ISBN-13: 0081021801

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Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks Analyzes and compares experimental data Presents in-depth information on the physical properties of polymeric gels using mathematical models Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances

pH of the Skin: Issues and Challenges
pH of the Skin: Issues and Challenges

Author: C. Surber

Publisher: Karger Medical and Scientific Publishers

Published: 2018-08-21

Total Pages: 214

ISBN-13: 3318063851

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The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research. Reports on results of pH measurements from living skin established the term acid mantle - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is therefore no surprise, that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and "correct" skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity. Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data. In this volume, we present a unique collection of papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.

Dermoscopy in General Dermatology
Dermoscopy in General Dermatology

Author: Aimilios Lallas

Publisher: CRC Press

Published: 2018-09-03

Total Pages: 719

ISBN-13: 1351782886

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This lavishly illustrated guide from experts will enable practitioners to get the most out of dermoscopy for investigations and treatments in general dermatology.

Human Oral Mucosa
Human Oral Mucosa

Author: Christopher Squier

Publisher: John Wiley & Sons

Published: 2010-12-29

Total Pages: 151

ISBN-13: 0470959738

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Human Oral Mucosa: Development, Structure and Function is a new text that reflects the considerable increase in knowledge of oral mucosa that has occurred in recent years. Our understanding of the structure of oral mucosa is now established at a molecular rather than a tissue or cellular level. This in turn has revealed a level of function that was previously not suspected, including a sophisticated barrier to the penetration of exogenous materials, and the synthesis of specific antimicrobial compounds, representing components of the innate immune system. There is also a growing realization of commonality in structure and function between regions of oral mucosa and the mucosae of the esophagus and vagina. The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.

Drug Discovery and Development
Drug Discovery and Development

Author: Omboon Vallisuta

Publisher: BoD – Books on Demand

Published: 2015-06-03

Total Pages: 332

ISBN-13: 9535121286

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It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Topical and Transdermal Drug Delivery
Topical and Transdermal Drug Delivery

Author: Heather A. E. Benson

Publisher: John Wiley & Sons

Published: 2012-02-03

Total Pages: 393

ISBN-13: 1118140494

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Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.