Time, Genetics and Complex Disease
Author: Guang-Zhong Wang
Publisher: Frontiers Media SA
Published: 2023-06-22
Total Pages: 148
ISBN-13: 2832503594
DOWNLOAD EBOOKBiological traits and diseases tend to be very complex. Time is an aspect that deserves particular attention to study and decipher biological traits and disease mechanisms: many processes including biological rhythms, neurodevelopmental and neurodegenerative mechanisms, and aging have a time-dependent trajectory. Biological rhythms, such as circadian rhythms are a reflection of biological processes over 24 hours. In the case of developmental and aging processes, they reflect biological activities over a much longer time scale, typically across years or even decades. In recent years these research fields have been cross-fertilizing each other. Examples include apparent alterations of circadian regulation in adult and aging individuals and a potential link between circadian disruption and Autism Spectrum Disorders, Alzheimer’s Disease, and Major Depressive Disorder. Recent research aimed at decoding these time-related complexities has led to the implementation and utilization of various -omics methods. Transcriptomics and proteomics have matured into “standard” methods for profiling expression changes on a large scale across different time points. Single-cell sequencing technology will gain popularity for decoding cell-type diversity. With regard to data analysis, the identification of differentially expressed genes and proteins across time is of great interest. Granted, there are also topic-specific methods too. For circadian rhythm research, molecules that show rhythmic activity signals are of prime interest, whereas for life span studies the major focus is the identification of genes whose expression changes over long time periods. These topic-specific research methods can greatly benefit from each other’s expertise.
