Privileged Scaffolds in Drug Discovery
Privileged Scaffolds in Drug Discovery

Author: Bin Yu

Publisher: Elsevier

Published: 2023-07-19

Total Pages: 988

ISBN-13: 044318612X

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Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs

Progress in the Chemistry of Organic Natural Products 102
Progress in the Chemistry of Organic Natural Products 102

Author: A. Douglas Kinghorn

Publisher: Springer

Published: 2016-07-05

Total Pages: 258

ISBN-13: 3319331728

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The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Medicinal Plants in the Asia Pacific for Zoonotic Pandemics, Volume 2
Medicinal Plants in the Asia Pacific for Zoonotic Pandemics, Volume 2

Author: Christophe Wiart

Publisher: CRC Press

Published: 2021-09-28

Total Pages: 365

ISBN-13: 1000442942

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Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional medical systems of Asia and Pacific medicine for the treatment of microbial infections. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents for each plant the botanical classification, synonyms, scientific names, local names, habitat, distribution, botanical description, traditional medicinal uses, antimicrobial activities, active antimicrobial principles, and commentaries. This volume is a critical reference for anyone involved in the development of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Includes phylogenetic presentations of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses the chemical structure–activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of handmade botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of leads or herbals from Asia-Pacific medicinal plants to safeguard humanity against COVID-19 and the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.

Handbook of Natural Toxins
Handbook of Natural Toxins

Author: R. F. Keeler

Publisher: CRC Press

Published: 1991-03-01

Total Pages: 760

ISBN-13: 9780824783754

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This volume describes some of the new research published since volume 1 of the series, Plant and fungal toxins , was published in 1983. A few chapters update topics previously treated, but most describe in depth the toxicologic and chemical aspects of other topics. Thus volumes 1 and 6 together prov

Terpenoids
Terpenoids

Author: Bimal Krishna Banik

Publisher: CRC Press

Published: 2022-12-23

Total Pages: 1181

ISBN-13: 1000823520

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This unique volume covers specific aspects of the biological chemistry of terpenoids. It provides extensive information related to classification, general methods of extraction and isolation of terpenoids, synthesis and pharmacological activities of monoterpenoids, synthesis and medicinal uses of diterpenoids, biogenesis of terpenoids, synthesis and medicinal uses of sesqui terpenoids and sesterpenoids. Some terpenes are also classified as diterpene alkaloids. Most of the terpenoids with diverse molecular structures are biologically active and are used for the treatment of various diseases such as cancer, malaria, inflammation, tuberculosis and infection, and this is discussed. Features: Activities and biological relationships of terpenes An accurate assessment of where and what terpenes can lead to Discusses how microbes, in particular the actinomycetales, have well over 400 different gene clusters that produce terpenes Arranged by biological activities and usage Provides information on eukaryotic enzymes that have been shown to be a source of “ethnobotanical” terpenes

Novel Plant Natural Product Skeletons
Novel Plant Natural Product Skeletons

Author: Yongxian Cheng

Publisher: Springer Nature

Published: 2024-02-02

Total Pages: 351

ISBN-13: 9819973295

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This book provides an overview of the new plant natural product skeletons discovered from 1999 to 2021. It categorizes these natural products by providing their names, source distributions, structural types, structure characteristics, and bioactivities. A total of 1373 plant products in 99 families are presented, which cover 36 different structure types within the Hypericaceae family of which the majority are alkaloid structures. In addition, it presents the biological profiling in the last 23 years by summarizing the biological activities and potential disadvantages. The new natural products skeleton presented are unprecedented structural scaffolds and could bring new opportunities for biological/pharmaceutical areas and provide new structure templates for synthetic chemists. This book helps readers gain in-depth insight into the past and recent trends of natural products; it also assists those interested in assessing the potential biological function of the natural products.