Three Variations on the Theme of Comparative Genomics
Author: Kevin Christopher Chen
Publisher:
Published: 2005
Total Pages: 228
ISBN-13:
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Concepts in Bioinformatics and Genomics
Author: Jamil Momand
Publisher:
Published: 2017
Total Pages: 0
ISBN-13: 9780190610548
DOWNLOAD EBOOKReview of molecular biology 1 -- Information organization and sequence databases -- Molecular evolution -- Substitution matrices -- Pairwise sequence alignment-- Basic local alignment sequence tool and multiple sequence alignment -- Protein structure prediction -- Phylogenetics -- Genomics -- Transcript and protein expression analysis -- Basic probability -- Advanced probability for bioinformatics applications -- Programming basics and applications to bioinformatics -- Developing a bioinformatics tool
The New Science of Metagenomics
Author: National Research Council
Publisher: National Academies Press
Published: 2007-06-24
Total Pages: 170
ISBN-13: 0309106761
DOWNLOAD EBOOKAlthough we can't usually see them, microbes are essential for every part of human life-indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying-one at a time-the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.
The Conifers: Genomes, Variation and Evolution
Author: David B. Neale
Publisher: Springer
Published: 2019-03-23
Total Pages: 593
ISBN-13: 3319468073
DOWNLOAD EBOOKThis book is the first comprehensive volume on conifers detailing their genomes, variations, and evolution. The book begins with general information about conifers such as taxonomy, geography, reproduction, life history, and social and economic importance. Then topics discussed include the full genome sequence, complex traits, phenotypic and genetic variations, landscape genomics, and forest health and conservation. This book also synthesizes the research included to provide a bigger picture and suggest an evolutionary trajectory. As a large plant family, conifers are an important part of economic botany. The group includes the pines, spruces, firs, larches, yews, junipers, cedars, cypresses, and sequoias. Of the phylum Coniferophyta, conifers typically bear cones and evergreen leaves. Recently, there has been much data available in conifer genomics with the publication of several crop and non-crop genome sequences. In addition to their economic importance, conifers are an important habitat for humans and animals, especially in developing parts of the world. The application of genomics for improving the productivity of conifer crops holds great promise to help provide resources for the most needy in the world.
Foundations of Comparative Genomics
Author: Arcady R. Mushegian
Publisher: Elsevier
Published: 2010-07-20
Total Pages: 276
ISBN-13: 0080546099
DOWNLOAD EBOOKThis book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. - Presents an historic overview of genome biology and its achievements - Includes topics not covered in other books such as minimal and ancestral genomes - Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level - Critically reviews horizontal gene transfer and other contentious issues - Covers comparative virology as a somewhat overlooked foundation of modern genome science
Next Steps for Functional Genomics
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2020-12-18
Total Pages: 201
ISBN-13: 0309676738
DOWNLOAD EBOOKOne of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
The Pangenome
Author: Hervé Tettelin
Publisher: Springer Nature
Published: 2020-04-30
Total Pages: 311
ISBN-13: 3030382818
DOWNLOAD EBOOKThis open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Comparative Genomics
Author: João Carlos Setubal
Publisher: Springer Nature
Published:
Total Pages: 622
ISBN-13: 1071638386
DOWNLOAD EBOOKSequence — Evolution — Function
Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
Published: 2013-06-29
Total Pages: 482
ISBN-13: 1475737831
DOWNLOAD EBOOKSequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Solutions Manual for An Introduction to Genetic Analysis
Author: David Scott
Publisher: Macmillan
Published: 2010-12-24
Total Pages: 862
ISBN-13: 1429232552
DOWNLOAD EBOOKSince its inception, Introduction to Genetic Analysis (IGA) has been known for its prominent authorship including leading scientists in their field who are great educators. This market best-seller exposes students to the landmark experiments in genetics, teaching students how to analyze experimental data and how to draw their own conclusions based on scientific thinking while teaching students how to think like geneticists. Visit the preview site at www.whfreeman.com/IGA10epreview
