Some extraordinary rats come to the aid of a mouse family in this Newbery Medal Award–winning classic by notable children’s author Robert C. O’Brien. Mrs. Frisby, a widowed mouse with four small children, is faced with a terrible problem. She must move her family to their summer quarters immediately, or face almost certain death. But her youngest son, Timothy, lies ill with pneumonia and must not be moved. Fortunately, she encounters the rats of NIMH, an extraordinary breed of highly intelligent creatures, who come up with a brilliant solution to her dilemma. And Mrs. Frisby in turn renders them a great service.
Rhymes from Mother Goose and other classic sources inspired these 85 imaginative illustrations. Humorous and bizarre, they add a new depth and resonance to the familiar verses. Contains mature content.
“Three Years with the Rat is a mind-warping thriller that will make you question reality as you conceive of it. One of the most assured and haunting debuts I’ve read in recent memory.” —Blake Crouch, author of Dark Matter After several years of drifting between school and go-nowhere jobs, a young man is drawn back into the big city of his youth. The magnet is his beloved older sister, Grace: always smart and charismatic even when she was rebelling, and always his hero. Now she is a promising graduate student in psychophysics and the center of a group of friends who take “Little Brother” into their fold, where he finds camaraderie, romance, and even a decent job. But it soon becomes clear that things are not well with Grace. Always acerbic, she now veers into sudden rages that are increasingly directed at her adoring boyfriend, John, who is also her fellow researcher. When Grace disappears, and John shortly thereafter, the narrator makes an astonishing discovery in their apartment: a box big enough to crawl inside, a lab rat, and a note that says This is the only way back for us. Soon he embarks on a mission to discover the truth, a pursuit that forces him to question time and space itself, and ultimately toward a perilous confrontation at the very limits of imagination. This kinetic novel catapults the classic noir plot of a woman gone missing into the twenty-first-century city, where so-called reality crashes into speculative science. Jay Hosking's Three Years with the Rat is simultaneously a mind-twisting mystery that plays with the very nature of time and the story of a young man who must face the dangerously destructive forces we all carry within ourselves.
Emmy was a good girl. At least she tried very hard to be good. She did her homework without being told. She ate all her vegetables, even the slimy ones. And she never talked back to her nanny, Miss Barmy, although it was almost impossible to keep quiet, some days. She really was a little too good. Which is why she liked to sit by the Rat. The Rat was not good at all . . . Hilarious, inventive, and irresistably rodent-friendly, Emmy and the Incredible Shrinking Rat is a fantastic first novel from acclaimed picture book author Lynne Jonell.
For six months in 1942, Stalingrad is the center of a titanic struggle between the Russian and German armies—the bloodiest campaign in mankind's long history of warfare. The outcome is pivotal. If Hitler's forces are not stopped, Russia will fall. And with it, the world.... German soldiers call the battle Rattenkrieg, War of the Rats. The combat is horrific, as soldiers die in the smoking cellars and trenches of a ruined city. Through this twisted carnage stalk two men—one Russian, one German—each the top sniper in his respective army. These two marksmen are equally matched in both skill and tenacity. Each man has his own mission: to find his counterpart—and kill him. But an American woman trapped in Russia complicates this extraordinary duel. Joining the Russian sniper's cadre, she soon becomes one of his most talented assassins—and perhaps his greatest weakness. Based on a true story, this is the harrowing tale of two adversaries enmeshed in their own private war—and whose fortunes will help decide the fate of the world.
Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high prevalence of chronic pain, its management is still no fully satisfactory probably due to the variety of chronic pain conditions with different etiologies (neuropathic, visceral and musculoskeletal pain), and because their pathophysiological mechanisms are only partially known. Therefore, there is a huge need for new effective therapies for the control and/or prevention of the different types of chronic pain. Chronic pain is associated with plastic changes in pain circuits of the peripheral and central nervous system, including changes in the expression of ion channels, neurotransmitters and receptors. In addition, there is growing consensus on non-neuronal mechanisms that can amplify or resolve chronic pain, and cells traditionally thought to act just as coordinators of the inflammatory response (such as immune and glial cells) are now accepted as real modulators of pain signaling. In this regard, animal models of persistent pain, such as models of neuropathic and visceral pain and models of arthritis, are helping to elucidate our understanding of the pathogenesis of chronic pain and make it possible to test experimental treatments.