Solid State Characterization of Pharmaceuticals

Solid State Characterization of Pharmaceuticals

Author: Richard A. Storey

Publisher: John Wiley & Sons

Published: 2011-03-31

Total Pages: 557

ISBN-13: 1119970172

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The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection


Characterisation of Polymers by Thermal Analysis

Characterisation of Polymers by Thermal Analysis

Author: W.M. Groenewoud

Publisher: Elsevier

Published: 2001-05-21

Total Pages: 407

ISBN-13: 0080528937

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Thermal Analysis (TA) has become an indispensable family of analytical techniques in the polymer research. The increased importance of these techniques can be seen as the result of three more or less parallel developments:• a tempestuous development of TA measuring techniques in combination with a high degree of automation,• the strongly increased understanding of the underlaying theory and,• the increasing knowledge of the relation between the polymers' chemical structure and their physical properties.These areas are still in their developmental stages, especially the third area. The increasing knowledge of the dependence of physical properties on chemical structure just accentuated more and more the need for accurate thermoanalytical measurements, and this knowledge is very important for the first stages of the development of new polymeric systems. Besides, the contribution of TA remains necessary for the technical and commercial development of such a new polymer system. The use of the various TA techniques in these processes is described in this book in nine chapters, while chapter ten illustrates the information obtained about different polymers during special case studies.This book illustrates in this way, applications of a wide variety of TA techniques whilst it is written from a materials characterisation rather than from a TA point of view with attention being paid to the chemical structure/physical properties correlations.


Thermoluminescence of Solids

Thermoluminescence of Solids

Author: S. W. S. McKeever

Publisher: Cambridge University Press

Published: 1985

Total Pages: 396

ISBN-13: 9780521368117

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McKeever gives us a comprehensive survey of thermoluminescence, an important, versatile, and widely used experimental technique. Bringing together previously isolated specialized approaches, he stresses the importance of the solid state aspects of the phenomenon. The book contains chapters on analysis and special properties, on instrumentation, and on the variety of defect reaction - using the alkali halides and SiO2 as examples - that can take place within a material to yield thermoluminescence. Three chapters concerning applications discuss the features of the solid state reactions to expain some of the properties observed in practice.


Dielectric Phenomena in Solids

Dielectric Phenomena in Solids

Author: Kwan Chi Kao

Publisher: Academic Press

Published: 2004-03-11

Total Pages: 602

ISBN-13: 0123965616

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The only available, comprehensive reference on dielectric phenomena in solids.


Dual-Phase Depolarization Analysis

Dual-Phase Depolarization Analysis

Author: Jean Pierre Ibar

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2022-05-09

Total Pages: 610

ISBN-13: 3110756749

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The book describes and explains thermally stimulated current depolarization and thermal sampling. Electrical charges are created in the dielectric material by a voltage field. Analyzing how the current discharges provides insights into the atomic structure of the polymer, its organization and free volume. The book also includes case studies teaching how to apply the characterization techniques to understand the behavior of polymers.


Structure and Properties of Ionomers

Structure and Properties of Ionomers

Author: Michel Pineri

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 579

ISBN-13: 9400938292

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Ionomers, that is polymers containing a low concentration of charged units along the chain, have been the subject of increasing interest during the past twenty years. The presence of ionic groups in the poly mer changes some of its properties dramatically. Increases in the modu lus and the viscosity of several orders of magnitude have been observed, and changes in the glass transition of hundreds of degrees are possible. In addition, diffusion coefficients can be modified drastically. These changes are due primarily to the presence of reversible ionic cross links in these materials. Because of the low dielectric constant of most organic polymers, the ions or ionic dipoles tend to aggregate ; this aggregation process, however, is limited, because the ionic groups are covalently bonded to the organic chain. Host of the fundamental research done on these materials has been devoted to a determination of the extent of association, the structure of the aggregates, the limi ting factors, and the correlations between molecular and supermolecular structure and the resul ting properties.