Natural Poisons and Venoms
Natural Poisons and Venoms

Author: Eberhard Teuscher

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2023-06-06

Total Pages: 485

ISBN-13: 3110724863

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Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs. The present book is the first volume of the 5-volume series "Natural Poisons and Venoms". Volumes 1-3 cover poisons produced by plants, volume 4 summarizes poisons and venoms of animals and volume 5 deal with poisons of fungi, cyanobacteria, and other microorganisms. This volume starts with a fundamental chapter on history, chemistry and pharmacology of natural toxins, importance of the toxins for their producer, potential danger for humans and animals, and general aspects of toxicology including notes for first aid and proposals for clinical measures. The following chapters focus on the poisonous representatives of terpenes and the related steroids. The reader will be informed about the botany and occurrence of plants producing these toxins, the chemistry, the biogenesis and the pharmacology of the toxins, possible causes of poisonings, precautions to avoid poisonings, symptoms of poisonings of humans and animals, proposals for treatment measures and the possible usefulness, in the past, in present and in the future, of these toxins, especially for the development of new medicines. Numerous images of plants and chemical structural formulas complete the book. Extensive lists of literature references are given. The handbook is intended for physicians, veterinarians, pharmacists, chemists, biochemists, food chemists and biologists, for the students in the relevant fields, and also for interested laymen. You will be informed about all aspects of natural toxins based on the latest knowledge.

Venom and Toxin as Targeted Therapy
Venom and Toxin as Targeted Therapy

Author: Hang Fai (Henry) Kwok

Publisher: MDPI

Published: 2019-10-01

Total Pages: 178

ISBN-13: 3039211897

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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Venom and Toxin as Targeted Therapy
Venom and Toxin as Targeted Therapy

Author: Hang Fai Henry Kwok

Publisher:

Published: 2019

Total Pages: 1

ISBN-13: 9783039211906

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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Venoms to Drugs
Venoms to Drugs

Author: Glenn King

Publisher: Royal Society of Chemistry

Published: 2015-02-11

Total Pages: 338

ISBN-13: 1849736634

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This unique book will provide an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book will provide the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

Spider Venoms
Spider Venoms

Author: P. Gopalakrishnakone

Publisher: Springer

Published: 2016-05-10

Total Pages: 0

ISBN-13: 9789400763883

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In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Bee and Wasp Venoms Biological Characteristics and Therapeutic Application
Bee and Wasp Venoms Biological Characteristics and Therapeutic Application

Author:

Publisher:

Published: 2017-02-03

Total Pages:

ISBN-13: 9783038423409

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Bee or wasp venom therapy is the therapeutic application of honeybee venom or wasp venom to the treatment of various diseases. Venoms from either honeybees or wasps are known to possess a wide variety of pharmaceutical properties. Recent studies using these venoms have demonstrated diverse mechanisms on a range of conditions. However, identification of a single constituent out of the venom, the possible mechanisms, and a justification of the route of application and formulation are essential in the future. Understanding the signalling pathways associated with the compound-mediated in vivo dynamics and further communication between cells at the molecular level will facilitate the development of new therapeutics.

Arthropod Venom Components and Their Potential Usage
Arthropod Venom Components and Their Potential Usage

Author: Katsuhiro Konno

Publisher: MDPI

Published: 2020-03-25

Total Pages: 404

ISBN-13: 3039285408

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Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.