The Ubiquitin-Proteasome System and Disease, Volume 4
The Ubiquitin-Proteasome System and Disease, Volume 4

Author: R. John Mayer

Publisher: John Wiley & Sons

Published: 2007-12-03

Total Pages: 262

ISBN-13: 9783527314362

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This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research. From the contents: * Ubiquitin and cancer * Ubiquitin and liver cancer * Muscle atrophy * Aggresomes and human disease * Parkin and neurodegeneration * Chronic neurodegenerative diseases * Parkinson's disease * Ubiquitin and viruses * Druggability of the ubiquitin-proteasome system Required reading for molecular and cell biologists, as well as physiologists with an interest in the topic.

Ubiquitin Proteasome System
Ubiquitin Proteasome System

Author: Aldrin V. Gomes

Publisher: Nova Medicine & Health

Published: 2018

Total Pages: 0

ISBN-13: 9781536135183

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Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.

Ubiquitin and the Biology of the Cell
Ubiquitin and the Biology of the Cell

Author: Jan-Michael Peters

Publisher: Springer Science & Business Media

Published: 1998-05-31

Total Pages: 498

ISBN-13: 0306456494

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The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.

Ubiquitin Proteasome System
Ubiquitin Proteasome System

Author: Matthew Summers

Publisher: BoD – Books on Demand

Published: 2019-06-19

Total Pages: 228

ISBN-13: 1838804900

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The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Frontiers in Clinical Drug Research - Diabetes and Obesity: Volume 4
Frontiers in Clinical Drug Research - Diabetes and Obesity: Volume 4

Author: Atta-ur-Rahman

Publisher: Bentham Science Publishers

Published: 2019-01-18

Total Pages: 280

ISBN-13: 1681084457

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Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The fourth volume of this series features 7 chapters: -Pharmacologic Obesity Treatment -Interplay Between Bile Acid and GLP-1 Receptor Agonist Signaling Informs the Design of Drugs to Combat Obesity and its Metabolic Complications -Sodium–Glucose Co-Transporters Inhibitors for Type 2 Diabetes Mellitus -The Effects of Traditional Chinese Medicine on Inflammatory Cytokines in Diabetic Nephropathy -Through the Perspective of Histology – The Alzheimer’s Disease Promotion by Obesity and Glucose Metabolism: Type 3 Diabetes -Pharmacological Mechanism of PPARγ Ratio in Diabetes and Obesity -Hydrogen Sulfide and Carbohydrate Metabolism

Reversibility of Chronic Disease and Hypersensitivity, Volume 4
Reversibility of Chronic Disease and Hypersensitivity, Volume 4

Author: William J. Rea

Publisher: CRC Press

Published: 2017-11-22

Total Pages: 1187

ISBN-13: 1315357143

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Reversibility of Chronic Disease and Hypersensitivity, Volume 4: The Environmental Aspects of Chemical Sensitivity is the fourth of an encyclopedic five-volume set describing the basic physiology, chemical sensitivity, diagnosis, and treatment of chronic degenerative disease studied in a 5x less polluted controlled environment. This text focuses on treatment techniques, strategies, protocols, prescriptions, and technologies. Distinguishing itself from previous works on chemical sensitivity, it explains newly understood mechanisms of chronic disease and hypersensitivity, involving core molecular function. The authors discuss new information on ground regulation system, genetics, the autonomic nervous system, and immune and non-immune functions. The book also includes the latest technology and cutting-edge techniques, numerous figures, and supporting research.

Protein Degradation in Health and Disease
Protein Degradation in Health and Disease

Author: Michèle Reboud-Ravaux

Publisher: Springer Science & Business Media

Published: 2002

Total Pages: 152

ISBN-13: 9783540425946

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Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Enzymes—Advances in Research and Application: 2013 Edition
Enzymes—Advances in Research and Application: 2013 Edition

Author:

Publisher: ScholarlyEditions

Published: 2013-06-21

Total Pages: 720

ISBN-13: 1481675397

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Enzymes—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Transferases. The editors have built Enzymes—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Transferases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Enzymes—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Proteostasis and Disease
Proteostasis and Disease

Author: Rosa Barrio

Publisher: Springer Nature

Published: 2020-04-09

Total Pages: 350

ISBN-13: 3030382664

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This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.