First published as a serialized children's story in 1881-1882, Robert Louis Stevenson's Treasure Island has become an enduring classic. It has all the elements of a great adventure story: a plot full of twists and turns, an escalating sense of treachery and impending disaster, and a quintessential villain. Teenager Jim Hawkins finds a map titled "Treasure Island" in the belongings of a stricken lodger at the Admiral Benbow Inn in 1750s England. He soon finds himself aboard the schooner Hispaniola with a crew of disguised pirates headed to the Caribbean on a quest to find buried treasure. Long John Silver, the peg-legged cook, is the leader of this wretched crew. He is both engaging and ruthless, feared by even his barbarous accomplices, and a shape-shifter, pretending to be Jim's good friend and enemy, secretly plotting a mutiny. When mutiny begins, Jim must save the day. This beloved adventure story is pure fiction--but fiction well grounded in historical and geographical reality. In The Annotated Treasure Island, editor and researcher Simon Barker-Benfield meticulously and lovingly annotates this voyage, offering crucial factual information, a sociopolitical context, and clear technical explanations that bring you closer to the action. Lavishly illustrated with pictures of nautical equipment, parts of ships, and period maps, The Annotated Treasure Island brings the seafaring vernacular to life. You'll learn about "blocks," "backstays," and "shrouds." And you'll see Jim and the crew handle the Hispaniola, whether it's the "simple" chore of raising the anchor--which in a similar, real vessel could require three hours'-worth of hauling in a very slimy cable six inches at a time--or the difficulty and meaning of "warping" and "putting a man in the chains" in order to take depth soundings. The story illustrations by Louis Rhead (1857-1926) deftly draw out the escalating dramatic tension. Would all the risk and hardship have been worth it? Just how much treasure was the crew after? What could one have bought with 700,000 pounds sterling in the 1700s? Even that question is answered in this newly annotated edition: it would have been enough to buy and outfit a fleet of eleven 104-gun battleships of the period. Seven hundred thousand pounds sterling was serious money, enough money that some men would do almost anything to get it.
The ultimate alphabetically arranged thesaurus that will help you find the right word every time—now bigger and better than ever before! This all-new edition of the classic reference work is the one thesaurus no home or office should be without. As easy to use as a dictionary—and just as important for you to own—this is a unique and indispensable treasury of words that will enable you to express your ideas clearly and effectively. With the synonyms and antonyms for each word listed alphabetically for quick, convenient use, this superior reference volume will help you build your vocabulary, improve your writing skills, and enrich your powers of expression. • Simple to use—no index required • More than 5,000 new words and phrases • 2,000 new synonym entry words for more efficient cross-referencing • 30 new categories • Easy-to-read double-column format • Latest colloquial and slang terms • Quotations and phrases that reveal the fascinating history of each word and the ideas it represents
Anagram Solver is the essential guide to cracking all types of quiz and crossword featuring anagrams. Containing over 200,000 words and phrases, Anagram Solver includes plural noun forms, palindromes, idioms, first names and all parts of speech. Anagrams are grouped by the number of letters they contain with the letters set out in alphabetical order so that once the letters of an anagram are arranged alphabetically, finding the solution is as easy as locating the word in a dictionary.
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Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.