Clinical Pancreatology for Practising Gastroenterologists and Surgeons
Clinical Pancreatology for Practising Gastroenterologists and Surgeons

Author: Juan Enrique Dominguez-Munoz

Publisher: John Wiley & Sons

Published: 2021-03-17

Total Pages: 752

ISBN-13: 111957014X

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Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

The Exocrine Pancreas
The Exocrine Pancreas

Author: Stephen Pandol

Publisher: Morgan & Claypool Publishers

Published: 2011

Total Pages: 66

ISBN-13: 1615041389

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The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Medical Management of the Surgical Patient E-Book
Medical Management of the Surgical Patient E-Book

Author: Geno J. Merli

Publisher: Elsevier Health Sciences

Published: 2008-04-08

Total Pages: 859

ISBN-13: 1437710581

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This practical handbook delivers complete, to-the-point, evidence-based guidance on the preoperative, perioperative, and post-operative medical care of surgical patients. Each chapter focuses on a particular area of clinical concern, with concise presentations of pathophysiology, assessment and management options, the latest drug treatment information, and essential information on risk stratification and quality improvement. The result is an invaluable source on the management of surgical patients with co-existing medical problems that may be affected by surgery, as well as how to approach medical complications that may occur during or following surgical procedures. Comprehensive discussions at the beginning of each chapter emphasize consultation in surgical patient management. A concise, bulleted format lets you absorb key information at a glance. Extensively updated chapters. Easy-to-read tables present key information on each disorder, including classification, causes, risk factors and indexes, drug treatment information, mortality rates, laboratory findings, and postoperative complications. Recommendations accompanied by an assessment of the quality of supportive evidence, including randomized controlled trials, population based reviews, and consensus guidelines. A topical index takes you immediately to the answers you need. A new, smaller design makes the book easy to carry with you anywhere.

Acute Pancreatitis
Acute Pancreatitis

Author: Hans G. Beger

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 390

ISBN-13: 3642830277

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Provides findings on acute pancreatitis in the fields of morphology, epidemiology, pathophysiology, enzymatic and in- strumental diagnosis, clinical aspects and pharmacological and surgical treatment. Emphasis on clinical implications on the local release and vasoactice and toxic substances, the high rate of bacterial infection in the necroses, and the causes of impairment of cardiocirculatory, pulmonary and re- nal organs.

Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book
Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book

Author: Robert W. Wilmott

Publisher: Elsevier Health Sciences

Published: 2012-02-25

Total Pages: 1163

ISBN-13: 1455740500

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Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.

The Enzyme Treatment of Cancer and Its Scientific Basis
The Enzyme Treatment of Cancer and Its Scientific Basis

Author: John Beard

Publisher:

Published: 2010-01-01

Total Pages: 290

ISBN-13: 9780982196526

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In 1902, the scientist John Beard, at the time Professor at the University of Edinburgh, proposed that the pancreatic enzyme trypsin represents the body'¿¿s primary defense against cancer and would be useful as a cancer treatment. Despite his documentation and reputation '¿¿ he was nominated for the Nobel Prize in 1906 for his work in embryology '¿¿ most cancer experts rejected Beard'¿¿s thesis outright. However, not everyone dismissed Beard. A number of physicians employed pancreatic enzymes in the treatment of patients diagnosed with advanced cancer, often with remarkable results as reported in the scientific literature. These successes provoked a heated debate about the therapy in the first decade of the 20th century. In 1911 Beard published The Enzyme Treatment of Cancer and Its Scientific Basis, outlining his hypothesis, and the compelling results. Though published to some very positive reviews, the book was soon forgotten as the scientific community enthusiastically latched on to Madame Curie'¿¿s claim that radiation represented a simple non-toxic cure for cancer. It would be years before scientists realized radiation cured few cancers and was quite toxic '¿¿ Madame Curie herself died as a result of her exposure to uranium. Though Beard died in relative obscurity in 1924, contemporary evidence from molecular biology confirms many of his precepts.In 2010, nearly 100 years since publication of this book, it is time Beard'¿¿s work be reread. With billions of dollars spent in recent decades on cancer research with only slight success, Beard'¿¿s thesis warrants a thorough reconsideration.

Clinical Investigations in Gastroenterology
Clinical Investigations in Gastroenterology

Author: M.C. Bateson

Publisher: Springer Science & Business Media

Published: 1997-03-31

Total Pages: 266

ISBN-13: 9780792343912

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This volume is an up-to-date review of the basic tests in gastroenterology. It provides a critical analysis of recently developed tests and a thorough appraisal of well-established methods. The text of this edition has been completely revised and re-organised. The selection of tests, their performance and the interpretation of results is presented in a logical and readily accessible format. Most of the chapters deal with the separate organ systems. Copious references to further reading are provided throughout the text, which is enhanced by clear illustrations. Topics covered include: Helicobacter pylori; upper digestive endoscopy; intubation; oesophagus; stomach; duodenum; small and large bowel; absorption; gastrointestinal bleeding; stool examination; pancreas; liver biochemistry, biopsy and radiology; gallbladder and bile ducts; pancreas; laparoscopy and the peritoneum.

Pediatric Respiratory Medicine
Pediatric Respiratory Medicine

Author: Lynn Max Taussig

Publisher: Elsevier Health Sciences

Published: 2008-01-01

Total Pages: 1401

ISBN-13: 0323040489

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This user-friendly text presents current scientific information, diagnostic approaches, and management strategies for the care of children with acute and chronic respiratory diseases. A consistent chapter format enables rapid and effortless location of the most current protocols on manifestations, etiologies, triggers, approaches to treatment, complications, and preventative strategies. Includes guidance on differential diagnosis to help determine which disease or condition the patient may have. Uses extensive color-coded algorithms to facilitate quick diagnosis, management, and treatment decisions. Provides the latest scientific information and diagnostic and management strategies for the care of children with respiratory illnesses. Presents cutting-edge coverage with new information on the biology of, and the influences on, the respiratory system during childhood, as well as the diagnosis and management of both common (ie, wheezing infant, cystic fibrosis, tuberculosis) and.

Therapeutic Enzymes: Function and Clinical Implications
Therapeutic Enzymes: Function and Clinical Implications

Author: Nikolaos Labrou

Publisher: Springer Nature

Published: 2019-09-03

Total Pages: 388

ISBN-13: 981137709X

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Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

History of the Pancreas: Mysteries of a Hidden Organ
History of the Pancreas: Mysteries of a Hidden Organ

Author: John M. Howard

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 763

ISBN-13: 1461505550

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Never before has a comprehensive history of the pancreas like History of the Pancreas been published. It not only is a historical review of the science of medicine, it is liberally interspersed with anecdotal vignettes of the researchers who have worked on this organ. Much of it, such as the discovery of the duct of Wirsüng, of the islets of Langerhans, of insulin, gastrin and their tumors, reads like the adverture, which it is. This book, divided into 14 chapters, is written in a narrative style and is easily readable, as glimpses of the investigators, those who failed as well as those who succeeded, adds both perspective and human interest. Each chapter is completely referenced, totaling over 1500 references. As a reference book for students, teachers, investigators, writers, its detailed hjistorical documentation is unique. From the pre-Christian era of Asia Minor, to Greece, Rome, Europe and America, to the explosive progress in Japan, the history is there. History of the Pancreas: Mysteries of a Hidden Organ fills a gap.