The Regulation of Cellular Systems

The Regulation of Cellular Systems

Author: Reinhart Heinrich

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 387

ISBN-13: 1461311616

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There is no doubt that nowadays, biology benefits greatly from mathematics. In particular, cellular biology is, besides population dynamics, a field where tech niques of mathematical modeling are widely used. This is reflected by the large number of journal articles and congress proceedings published every year on the dynamics of complex cellular processes. This applies, among others, to metabolic control analysis, where the number of articles on theoretical fundamentals and experimental applications has increased for about 15 years. Surprisingly, mono graphs and textbooks dealing with the modeling of metabolic systems are still exceptionally rare. We think that now time is ripe to fill this gap. This monograph covers various aspects of the mathematical description of enzymatic systems, such as stoichiometric analysis, enzyme kinetics, dynamical simulation, metabolic control analysis, and evolutionary optimization. We believe that, at present, these are the main approaches by which metabolic systems can be analyzed in mathematical terms. Although stoichiometric analysis and enzyme kinetics are classical fields tracing back to the beginning of our century, there are intriguing recent developments such as detection of elementary biochemical syn thesis routes and rate laws for the situation of metabolic channeling, which we have considered worth being included. Evolutionary optimization of metabolic systems is a rather new field with promising prospects. Its goal is to elucidate the structure and functions of these systems from an evolutionary viewpoint.


Function and Regulation of Cellular Systems

Function and Regulation of Cellular Systems

Author: Andreas Deutsch

Publisher: Birkhäuser

Published: 2012-12-06

Total Pages: 448

ISBN-13: 3034878958

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Current biological research demands the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. This highly interdisciplinary volume focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models. The book may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues such as tumor cell growth, dynamics of the immune system and biotechnology are included.


Bacterial Cellular Metabolic Systems

Bacterial Cellular Metabolic Systems

Author: K. Shimizu

Publisher: Elsevier

Published: 2013-03-26

Total Pages: 497

ISBN-13: 1908818204

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The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. - Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment - Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments - Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system


Handbook of Systems Biology

Handbook of Systems Biology

Author: Marian Walhout

Publisher: Academic Press

Published: 2012-12-31

Total Pages: 553

ISBN-13: 012385945X

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This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers


Cellular and Molecular Physiology of Cell Volume Regulation

Cellular and Molecular Physiology of Cell Volume Regulation

Author: Kevin Strange

Publisher: CRC Press

Published: 2020-01-16

Total Pages: 442

ISBN-13: 1000722082

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The ability to regulate cell volume in the face of osmotic challenge is one of the most fundamental of cellular homeostatic mechanisms. Cellular and Molecular Physiology of Cell Volume Regulation is an integrated collection of articles describing key aspects of cell volume control. The book has been organized around concepts and cellular/molecular processes rather than around mechanisms of volume regulation in specific cell types in order to make it more accessible to a multidisciplinary audience of students, instructors, and researchers.


The Regulation of Cellular Systems

The Regulation of Cellular Systems

Author: Reinhart Heinrich

Publisher: Taylor & Francis US

Published: 1996-08-31

Total Pages: 404

ISBN-13: 9780412032615

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This book deals with problems and approaches to cellular systems and will cover a wide range of cell types and cell systems, including nerve cells. It will be of interest to cell biologists interested in modeling, and to any students interested in the field. It will also apppeal to the theoretical and mathematical biology community, and would have relevance to individuals interested in evolutionary issues as they bear on cellular metabolic models. It will be a solid theoretical book, with an empirical base and an evolution connection, that fits exactly to the initial theme of the theoretical biology series.


Cellular Energy Metabolism and Its Regulation

Cellular Energy Metabolism and Its Regulation

Author: Daniel E. Atkinson

Publisher:

Published: 1977

Total Pages: 320

ISBN-13:

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Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book dea ...


Molecular and Cellular Regulation of Adaptation to Exercise

Molecular and Cellular Regulation of Adaptation to Exercise

Author: Claude Bouchard

Publisher: Academic Press

Published: 2015-11-16

Total Pages: 588

ISBN-13: 0128039922

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Molecular Aspects of Exercise Biology and Exercise Genomics, the latest volume in the Progress in Molecular Biology and Translational Science series includes a comprehensive summary of the evidence accumulated thus far on the molecular and cellular regulation of the various adaptations taking place in response to exercise. Changes in the cellular machinery are described for multiple tissues and organs in terms of signaling pathways, gene expression, and protein abundance. Adaptations to acute exercise as well as exposure to regular exercise are also discussed and considered. - Includes a comprehensive summary of the evidence accumulated thus far on the molecular and cellular regulation of the various adaptations taking place in response to exercise - Contains contributions from leading authorities - Informs and updates on all the latest developments in the field of exercise biology and exercise genomics


Molecular Biology of the Cell 6E - The Problems Book

Molecular Biology of the Cell 6E - The Problems Book

Author: John Wilson

Publisher: Garland Science

Published: 2014-11-21

Total Pages: 984

ISBN-13: 1317497279

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The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be