The Progress of Experiment
Author: Harry M. Marks
Publisher: Cambridge University Press
Published: 1997
Total Pages: 276
ISBN-13: 9780521785617
DOWNLOAD EBOOKExplores the origins of contemporary drug regulation and the modern clinical trial.
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Experiment-Driven Product Development
Author: Paul Rissen
Publisher: Apress
Published: 2019-11-21
Total Pages: 133
ISBN-13: 1484255283
DOWNLOAD EBOOKImproving your craft is a key skill for product and user experience professionals working in the digital era. There are many established methods of product development to inspire and focus teams—Sprint, Lean, Agile, Kanban—all of which focus on solutions to customer and business problems. Enter XDPD, or Experiment-Driven Product Development—a new approach that turns the spotlight on questions to be answered, rather than on solutions. Within XDPD, discovery is a mindset, not a project phase. In Experiment-Driven Product Development, author Paul Rissen introduces a philosophy of product development that will hone your skills in discovery, research and learning. By guiding you through a practical, immediately applicable framework, you can learn to ask, and answer, questions which will supercharge your product development, making teams smarter and better at developing products and services that deliver for users and businesses alike. When applying the XDPD framework within your organization, the concept of an experiment—a structured way of asking, and answering, questions—becomes the foundation of almost everything you do, instilling a constant sense of discovery that keeps your team inspired. All types of activities, from data analysis to writing software, are seen through the lens of research. Rather than treating research as a separate task from the rest of product development, this book approaches the entire practice as one of research and continuous discovery. Designing successful experiments takes practice. That’s where Rissen’s years of industry expertise come in. In this book, you are given step-by-step tools to ensure that meaningful, efficient progress is made with each experiment. This approach will prove beneficial to your team, your users, and most importantly, to your product’s lasting success. Experiment-Driven Product Development offers a greater appreciation of the craft of experimentation and helps you adapt it in your own context. In our modern age of innovation, XDPD can put you ahead. Go forth and experiment! What You Will LearnKnow how to approach product development in a leaner, more efficient wayUnderstand where and when experiments can be useful, and how they fit into pre-existing organization environments and processesRealize why you should be thinking about the simplest, useful thing rather than the minimum, viable productDiscover how to break down feature and design ideas into the assumptions and the premises that lie behind themAppreciate the importance of designing your experiments, and the statistical concepts that underpin their successMaster the art of communicating the results of experiments back to stakeholders, and help the results guide what happens next Who This Book is For Professionals working in digital product design and development, user experience, and service design. This book is best suited for those who work on digital products every day and want to adopt better approaches to gaining knowledge about their users, what works, and what does not work.
When Experiments Travel
Author: Adriana Petryna
Publisher: Princeton University Press
Published: 2009-04-27
Total Pages: 271
ISBN-13: 1400830826
DOWNLOAD EBOOKThe phenomenal growth of global pharmaceutical sales and the quest for innovation are driving an unprecedented search for human test subjects, particularly in middle- and low-income countries. Our hope for medical progress increasingly depends on the willingness of the world's poor to participate in clinical drug trials. While these experiments often provide those in need with vital and previously unattainable medical resources, the outsourcing and offshoring of trials also create new problems. In this groundbreaking book, anthropologist Adriana Petryna takes us deep into the clinical trials industry as it brings together players separated by vast economic and cultural differences. Moving between corporate and scientific offices in the United States and research and public health sites in Poland and Brazil, When Experiments Travel documents the complex ways that commercial medical science, with all its benefits and risks, is being integrated into local health systems and emerging drug markets. Providing a unique perspective on globalized clinical trials, When Experiments Travel raises central questions: Are such trials exploitative or are they social goods? How are experiments controlled and how is drug safety ensured? And do these experiments help or harm public health in the countries where they are conducted? Empirically rich and theoretically innovative, the book shows that neither the language of coercion nor that of rational choice fully captures the range of situations and value systems at work in medical experiments today. When Experiments Travel challenges conventional understandings of the ethics and politics of transnational science and changes the way we think about global medicine and the new infrastructures of our lives.
The Neglect of Experiment
Author: Allan Franklin
Publisher: Cambridge University Press
Published: 1989-09-29
Total Pages: 308
ISBN-13: 9780521379656
DOWNLOAD EBOOKWhat role have experiments played, and should they play, in physics? How does one come to believe rationally in experimental results? The Neglect of Experiment attempts to provide answers to both of these questions. Professor Franklin's approach combines the detailed study of four episodes in the history of twentieth century physics with an examination of some of the philosophical issues involved. The episodes are the discovery of parity nonconservation ( or the violation of mirror symmetry) in the 1950s; the nondiscovery of parity nonconservation in the 1930s, when the results of experiments indicated, at least in retrospect, the symmetry violation, but the significance of those results was not realized; the discovery and acceptance of CP ( combined parity-charge conjugations, paricle-antiparticle) symmetry; and Millikan's oil-drop experiment. Franklin examines the various roles that experiment plays, including its role in deciding between competing theories, confirming theories, and calling fo new theories. The author argues that one can provide a philosophical justification for these roles. He contends that if experiment plays such important roles, then one must have good reason to believe in experimental results. He then deals with deveral problems concerning such reslults, including the epistemology of experiment, how one comes to believe rationally in experimental results, the question of the influence of theoretical presuppositions on results, and the problem of scientific fruad. This original and important contribution to the study of the philosophy of experimental science is an outgrowth of many years of research. Franklin brings to this work more than a decade of experience as an experimental high-energy physicist, along with his significant contributions to the history and philosophy of science.
Sharing Clinical Trial Data
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2015-04-20
Total Pages: 236
ISBN-13: 0309316324
DOWNLOAD EBOOKData sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Against Their Will
Author: Allen M. Hornblum
Publisher: St. Martin's Press
Published: 2013-06-25
Total Pages: 284
ISBN-13: 1137363452
DOWNLOAD EBOOKDuring the Cold War, an alliance between American scientists, pharmaceutical companies, and the US military pushed the medical establishment into ethically fraught territory. Doctors and scientists at prestigious institutions were pressured to produce medical advances to compete with the perceived threats coming from the Soviet Union. In Against Their Will, authors Allen Hornblum, Judith Newman, and Gregory Dober reveal the little-known history of unethical and dangerous medical experimentation on children in the United States. Through rare interviews and the personal correspondence of renowned medical investigators, they document how children—both normal and those termed "feebleminded"—from infants to teenagers, became human research subjects in terrifying experiments. They were drafted as "volunteers" to test vaccines, doused with ringworm, subjected to electric shock, and given lobotomies. They were also fed radioactive isotopes and exposed to chemical warfare agents. This groundbreaking book shows how institutional superintendents influenced by eugenics often turned these children over to scientific researchers without a second thought. Based on years of archival work and numerous interviews with both scientific researchers and former test subjects, this is a fascinating and disturbing look at the dark underbelly of American medical history.
Bad Blood
Author: James H. Jones
Publisher: Simon and Schuster
Published: 1993
Total Pages: 324
ISBN-13: 0029166764
DOWNLOAD EBOOKThe modern classic of race and medicine updated with an additional chapter on the Tuskegee experiment's legacy in the age of AIDS.
Experiments in Democracy
Author: Benjamin J. Hurlbut
Publisher: Columbia University Press
Published: 2017-01-31
Total Pages: 376
ISBN-13: 0231542917
DOWNLOAD EBOOKHuman embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.
The Uses of Humans in Experiment
Author:
Publisher: BRILL
Published: 2016-03-11
Total Pages: 309
ISBN-13: 9004286713
DOWNLOAD EBOOKScientific experimentation with humans has a long history. Combining elements of history of science with history of medicine, The Uses of Humans in Experiment illustrates how humans have grappled with issues of consent, and how scientists have balanced experience with empiricism to achieve insights for scientific as well as clinical progress. The modern incarnation of ethics has often been considered a product of the second half of the twentieth century, as enshrined in international laws and codes, but these authors remind us that this territory has long been debated, considered, and revisited as a fundamental part of the scientific enterprise that privileges humans as ideal subjects for advancing research.
Medical Apartheid
Author: Harriet A. Washington
Publisher: Vintage
Published: 2008-01-08
Total Pages: 530
ISBN-13: 076791547X
DOWNLOAD EBOOKNATIONAL BOOK CRITICS CIRCLE AWARD WINNER • The first full history of Black America’s shocking mistreatment as unwilling and unwitting experimental subjects at the hands of the medical establishment. No one concerned with issues of public health and racial justice can afford not to read this masterful book. "[Washington] has unearthed a shocking amount of information and shaped it into a riveting, carefully documented book." —New York Times From the era of slavery to the present day, starting with the earliest encounters between Black Americans and Western medical researchers and the racist pseudoscience that resulted, Medical Apartheid details the ways both slaves and freedmen were used in hospitals for experiments conducted without their knowledge—a tradition that continues today within some black populations. It reveals how Blacks have historically been prey to grave-robbing as well as unauthorized autopsies and dissections. Moving into the twentieth century, it shows how the pseudoscience of eugenics and social Darwinism was used to justify experimental exploitation and shoddy medical treatment of Blacks. Shocking new details about the government’s notorious Tuskegee experiment are revealed, as are similar, less-well-known medical atrocities conducted by the government, the armed forces, prisons, and private institutions. The product of years of prodigious research into medical journals and experimental reports long undisturbed, Medical Apartheid reveals the hidden underbelly of scientific research and makes possible, for the first time, an understanding of the roots of the African American health deficit. At last, it provides the fullest possible context for comprehending the behavioral fallout that has caused Black Americans to view researchers—and indeed the whole medical establishment—with such deep distrust.
