The Postmortem Brain in Psychiatric Research
The Postmortem Brain in Psychiatric Research

Author: Galila Agam

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 426

ISBN-13: 1475736312

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Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders. This is the first book to summarize this research approach and the meaningful data which has recently been acquired.

The Neurobiological Basis of Suicide
The Neurobiological Basis of Suicide

Author: Yogesh Dwivedi

Publisher: CRC Press

Published: 2012-06-25

Total Pages: 485

ISBN-13: 143983881X

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With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Brain Banking
Brain Banking

Author:

Publisher: Elsevier

Published: 2018-02-27

Total Pages: 448

ISBN-13: 0444636420

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Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. - Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more - Serves as a valuable resource for staff in existing brain banks by highlighting best practices - Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers - Authored by leaders from brain banks around the globe – the broadest, most expert coverage available

Molecular Neuropathology
Molecular Neuropathology

Author: Gareth W. Roberts

Publisher: Cambridge University Press

Published: 1995-06-08

Total Pages: 204

ISBN-13: 9780521425582

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This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

The Postmortem Brain in Psychiatric Research
The Postmortem Brain in Psychiatric Research

Author: Galila Agam

Publisher: Springer Science & Business Media

Published: 2002

Total Pages: 426

ISBN-13: 9780792375548

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Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders. This is the first book to summarize this research approach and the meaningful data which has recently been acquired.

Neuropsychiatric Disorders
Neuropsychiatric Disorders

Author: Manfred Gerlach

Publisher: Springer Science & Business Media

Published: 2007-12-28

Total Pages: 326

ISBN-13: 3211735747

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This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

The Neuropathology of Schizophrenia
The Neuropathology of Schizophrenia

Author: Paul J. Harrison

Publisher:

Published: 2000-08-24

Total Pages: 402

ISBN-13:

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What is schizophrenia? This is one of the most controversial questions in psychiatry and mental health research; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a balanced, comprehensive and up-to-date overview of the neuropathology of schizophrenia and its interpretation, covering the latest evidence derived from all fields of research, from brain scans to microscopy. The authors include many of the foremost international authorities in this rapidly developing field.

Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide
Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide

Author: Brian Dean

Publisher: CRC Press

Published: 2019-02-13

Total Pages: 188

ISBN-13: 1482283417

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Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtain

A Handbook for the Study of Mental Health
A Handbook for the Study of Mental Health

Author: Teresa L. Scheid

Publisher: Cambridge University Press

Published: 2010

Total Pages: 735

ISBN-13: 0521491940

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The second edition of A Handbook for the Study of Mental Health provides a comprehensive review of the sociology of mental health. Chapters by leading scholars and researchers present an overview of historical, social and institutional frameworks. Part I examines social factors that shape psychiatric diagnosis and the measurement of mental health and illness, theories that explain the definition and treatment of mental disorders and cultural variability. Part II investigates effects of social context, considering class, gender, race and age, and the critical role played by stress, marriage, work and social support. Part III focuses on the organization, delivery and evaluation of mental health services, including the criminalization of mental illness, the challenges posed by HIV, and the importance of stigma. This is a key research reference source that will be useful to both undergraduates and graduate students studying mental health and illness from any number of disciplines.

Post-traumatic Stress Disorder (PTSD) and War-related Stress
Post-traumatic Stress Disorder (PTSD) and War-related Stress

Author: Canada. Veterans Affairs Canada

Publisher:

Published: 2006

Total Pages: 36

ISBN-13:

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This document provides information on post-traumatic stress disorder (PTSD) and war-related stress for veterans & their families. It begins with background on PTSD and traumatic events, then describes common symptoms of PTSD and why they develop. The next section reviews problems associated with PTSD, such as depression, anxiety, and impacts on work & family. The final sections provide suggestions on coping with the disorder and describe treatment methods.