Structure and Physics of Viruses
Structure and Physics of Viruses

Author: Mauricio G. Mateu

Publisher: Springer Science & Business Media

Published: 2013-06-04

Total Pages: 734

ISBN-13: 9400765525

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This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.

Viruses
Viruses

Author: Paula Tennant

Publisher: Academic Press

Published: 2018-03-12

Total Pages: 393

ISBN-13: 0128111941

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Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived 'interactomics' as defined by the molecules and the processes by which virus gene products interact with themselves and their host's cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses - Provides key insights into recent technological advances, including high-throughput sequencing - Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life - Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions

Structural Virology
Structural Virology

Author: Mavis Agbandje-McKenna

Publisher: Royal Society of Chemistry

Published: 2010-11-11

Total Pages: 389

ISBN-13: 184973223X

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Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

The Physics of Viruses
The Physics of Viruses

Author: Ernest C. Pollard

Publisher: Academic Press

Published: 2013-10-22

Total Pages: 243

ISBN-13: 1483270920

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The Physics of Viruses presents what is known about viruses from the viewpoint of a physicist. In so doing, a major aim has proved to be the description of viruses, their shape, and structure. Rather surprisingly, definite shapes and structures are emerging, and it is with a heightened sense of excitement that the hoped-for simplicity and symmetry are beginning to be found. The book contains eight chapters and opens with a discussion of the nature of viruses and their relation to physics. Subsequent chapters present studies on the size, shape, and hydration of viruses; the effects of ionizing radiation on viruses, thermal inactivation of viruses, biological effects of ultraviolet light, sonic and osmotic effects on viruses, and virus genetics and multiplication. The account given here should interest not only the physicist but that growing body of students who admit to being virologists as well. There is no doubt that the processes of viruses are in some way the processes of biology, so that the fundamental actions of biology may well be clarified by thinking about how viruses perform their work.

Emerging Topics in Physical Virology
Emerging Topics in Physical Virology

Author: Peter G. Stockley

Publisher: World Scientific

Published: 2010

Total Pages: 333

ISBN-13: 1848164661

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Emerging Topics in Physical Virology is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, their assembly and disassembly, the organization of the viral genome, infection, evolution, as well as applications of viruses in Biomedical Nanotechnology. It is an essential primer for scientists working in all aspects of virology, including the increasing use of viruses and virus-like particles in bio- and nano-technology. Its review style makes it moreover suitable for non-experts as an introduction into this exciting research area.

Physical Virology
Physical Virology

Author: Urs F. Greber

Publisher: Springer

Published: 2019-07-17

Total Pages: 235

ISBN-13: 303014741X

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This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference. Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution. The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.

A Planet of Viruses
A Planet of Viruses

Author: Carl Zimmer

Publisher: University of Chicago Press

Published: 2015-10-06

Total Pages: 133

ISBN-13: 022632026X

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For years, scientists have been warning us that a pandemic was all but inevitable. Now it's here, and the rest of us have a lot to learn. Fortunately, science writer Carl Zimmer is here to guide us. In this compact volume, he tells the story of how the smallest living things known to science can bring an entire planet of people to a halt--and what we can learn from how we've defeated them in the past. Planet of Viruses covers such threats as Ebola, MERS, and chikungunya virus; tells about recent scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and shares new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and, for all its honesty about the threats, as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a world we all need to better understand.

Virus
Virus

Author: Marilyn J. Roossinck

Publisher:

Published: 2016-08-24

Total Pages: 0

ISBN-13: 9781782403265

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Viruses are the last frontier of undiscovered life on our planet. The most abundant type of organism on Earth, they infect all types of cellular life, and, as micro-organisms that cause disease in their hosts, they are highly opportunistic and relentlessly efficient. They exist at the vanguard of DNA variance, exhibiting more structural diversity than plants, animals, archaea, or even bacteria. This 21st-century guide offers an engaging introductory section explaining exactly what viruses are and how they operate, followed by individual profiles of 101 of the world's most notable examples, each with its own dazzling mugshot

How Pathogenic Viruses Think
How Pathogenic Viruses Think

Author: Lauren Sompayrac

Publisher: Jones & Bartlett Publishers

Published: 2013

Total Pages: 182

ISBN-13: 1449645798

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Over the past decade, the amount of data on viruses has grown dramatically. How can a virology student possibly make sense of all this information? In How Pathogenic Viruses Think, Second Edition, Dr. Sompayrac introduces an "organizing principle" - a paradigm to use to cut through all the details and focus on what's important. He demonstrates the use of this paradigm by "interviewing" twelve medically important viruses. During these interviews, each virus is encouraged to disclose not only what it does, but why it does it. And when a "talking virus" reveals its secrets, they are hard to forget! How Pathogenic Viruses Think covers the essential elements of virus-host interactions with descriptive graphics, helpful mnemonic tactics for retaining the information, and brief reviews of important concepts. It is an ideal book to help medical, science, and nursing students make sense of this complex subject. Example: Interviewer: I always ask the viruses I interview, "How do you attack your hosts, and why have you chosen that route?" Flu Virus: I favor the respiratory route. Interviewer: Okay, but why? For example, why not enter via the digestive tract? Flu Virus: Are you kidding me? Do I look like a dumb virus to you? My Uncle Harold tried the digestive tract once, and got as far as the stomach before the acid in there ate him alive! Not me. I take the easy way in. The respiratory route of infection provides direct access to my favorite target cells - the epithelial cells which line the human airway.

Viruses: More Friends Than Foes (Revised Edition)
Viruses: More Friends Than Foes (Revised Edition)

Author: Karin Moelling

Publisher: World Scientific

Published: 2020-08-26

Total Pages: 446

ISBN-13: 9811224765

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Coronavirus, AIDS, and Ebola: Viruses are normally defined as pathogens. Most viruses are, however, not enemies or killers. Well-known virologist and cancer researcher Karin Moelling describes surprising insights about a completely new and unexpected world of viruses. Viruses are ubiquitous, in the oceans, our environment, in animals, plants, bacteria, in our body, even in our genomes. They influence our weather, can contribute to control obesity, and can surprisingly be applied against threatening multi-resistant bacteria. The success story of the viruses started more than 3.5 billion years ago in the dawn of life when even cells did not exist. They are the superpower of life. There are more viruses on earth than stars in the sky. Viruses are everywhere. Some of them are incredibly ancient. Many viruses are hundredfold smaller than bacteria, but others are tenfold bigger and they were discovered only recently — the giant viruses, even deep within the permafrost where they were reactivated after 30,000 years.The author talks about a completely new world of viruses, which are based on the most recent, in part her own research results. Could viruses have been our oldest ancestors? Have viruses even 'invented' social behavior, do they lead to geniuses such as Mozart or Einstein — or alternatively to cancer? They can help to cure cancer. In this book, the author made a clear distinction between what is fact and what is her vision. This book is written for a general audience and not just for the experts. Its aim is to stimulate thinking, and perhaps to attract more young scientists to enter this field of research.This revised edition is brought up to date by a new chapter on the SARS-CoV-2 pandemic. Related Link(s)