Orphans of the Living

Orphans of the Living

Author: Jennifer Toth

Publisher: Simon and Schuster

Published: 1998-07-02

Total Pages: 326

ISBN-13: 068484480X

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Jails, hospitals, and strip joints; the celebrations of straight-A report cards, graduations, and Congressional honors - as the children demonstrate their humor, hope, and resilience in trying to overcome their society's failure.


The Great Arizona Orphan Abduction

The Great Arizona Orphan Abduction

Author: Linda Gordon

Publisher: Harvard University Press

Published: 2011-02-09

Total Pages: 433

ISBN-13: 0674061713

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In 1904, New York nuns brought forty Irish orphans to a remote Arizona mining camp, to be placed with Catholic families. The Catholic families were Mexican, as was the majority of the population. Soon the town's Anglos, furious at this "interracial" transgression, formed a vigilante squad that kidnapped the children and nearly lynched the nuns and the local priest. The Catholic Church sued to get its wards back, but all the courts, including the U.S. Supreme Court, ruled in favor of the vigilantes. The Great Arizona Orphan Abduction tells this disturbing and dramatic tale to illuminate the creation of racial boundaries along the Mexican border. Clifton/Morenci, Arizona, was a "wild West" boomtown, where the mines and smelters pulled in thousands of Mexican immigrant workers. Racial walls hardened as the mines became big business and whiteness became a marker of superiority. These already volatile race and class relations produced passions that erupted in the "orphan incident." To the Anglos of Clifton/Morenci, placing a white child with a Mexican family was tantamount to child abuse, and they saw their kidnapping as a rescue. Women initiated both sides of this confrontation. Mexican women agreed to take in these orphans, both serving their church and asserting a maternal prerogative; Anglo women believed they had to "save" the orphans, and they organized a vigilante squad to do it. In retelling this nearly forgotten piece of American history, Linda Gordon brilliantly recreates and dissects the tangled intersection of family and racial values, in a gripping story that resonates with today's conflicts over the "best interests of the child."


Rare Diseases and Orphan Products

Rare Diseases and Orphan Products

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2011-04-03

Total Pages: 442

ISBN-13: 0309158060

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Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.


Orphan Trains

Orphan Trains

Author: Elizabeth Raum

Publisher: Capstone

Published: 2010-12

Total Pages: 113

ISBN-13: 1429662735

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"Describes the people and events involved in the orphan trains. The reader's choices reveal the historical details from the perspectives of a New York City newsboy, a child trying to keep his siblings together, and a child sent west on the baby trains"--Provided by publisher.


Clinical Trials

Clinical Trials

Author: Tom Brody

Publisher: Academic Press

Published: 2016-02-19

Total Pages: 897

ISBN-13: 0128042583

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Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. - Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more - Extensively covers the "study schema" and related features of study design - Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials - Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers


The Song of the Orphans

The Song of the Orphans

Author: Daniel Price

Publisher: Penguin

Published: 2017-07-04

Total Pages: 753

ISBN-13: 0399164995

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The thrilling second novel in the category-defying Silvers trilogy—melding X-Men and the novels of Blake Crouch—about six extraordinary people who become unwitting refugees on an unfamiliar Earth, and their epic quest to find out why. The end of the world was just the beginning for Hannah and Amanda Given. Saved from apocalypse by three mysterious beings, the sisters, along with four other refugees from their world, were each marked with a silver bracelet and transported to an entirely different Earth: a place where restaurants move through the air like flying saucers and the fabric of time is manipulated by common household appliances, as well as by their very own hands—and a place where terrifying new adversaries seem to be around every corner. Now, after six months in this alt-America and a tumultuous cross-country journey that landed them in New York City, the Silvers find themselves in more trouble than ever. Their new world is dying, and a clan of powerful time benders believes that killing them is the only way to stop it. To make matters worse, the U.S. government has sent its most ruthless covert spy agency to track and capture them. But the biggest threat of all comes from the three god-like beings who first saved them. They had a reason for bringing the Givens and their friends to this world. And when the Silvers learn the awful truth, nothing will ever be the same.


Principles and Practice of Clinical Trials

Principles and Practice of Clinical Trials

Author: Steven Piantadosi

Publisher: Springer Nature

Published: 2022-07-19

Total Pages: 2573

ISBN-13: 3319526367

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This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.