This book provides a comprehensive treatment of the design of blocked and split-plot experiments. The optimal design approach advocated in the book will help applied statisticians from industry, medicine, agriculture, chemistry and many other fields of study in setting up tailor-made experiments. The book also contains a theoretical background, a thorough review of the recent work in the area of blocked and split-plot experiments, and a number of interesting theoretical results.
"This is an engaging and informative book on the modern practice of experimental design. The authors' writing style is entertaining, the consulting dialogs are extremely enjoyable, and the technical material is presented brilliantly but not overwhelmingly. The book is a joy to read. Everyone who practices or teaches DOE should read this book." - Douglas C. Montgomery, Regents Professor, Department of Industrial Engineering, Arizona State University "It's been said: 'Design for the experiment, don't experiment for the design.' This book ably demonstrates this notion by showing how tailor-made, optimal designs can be effectively employed to meet a client's actual needs. It should be required reading for anyone interested in using the design of experiments in industrial settings." —Christopher J. Nachtsheim, Frank A Donaldson Chair in Operations Management, Carlson School of Management, University of Minnesota This book demonstrates the utility of the computer-aided optimal design approach using real industrial examples. These examples address questions such as the following: How can I do screening inexpensively if I have dozens of factors to investigate? What can I do if I have day-to-day variability and I can only perform 3 runs a day? How can I do RSM cost effectively if I have categorical factors? How can I design and analyze experiments when there is a factor that can only be changed a few times over the study? How can I include both ingredients in a mixture and processing factors in the same study? How can I design an experiment if there are many factor combinations that are impossible to run? How can I make sure that a time trend due to warming up of equipment does not affect the conclusions from a study? How can I take into account batch information in when designing experiments involving multiple batches? How can I add runs to a botched experiment to resolve ambiguities? While answering these questions the book also shows how to evaluate and compare designs. This allows researchers to make sensible trade-offs between the cost of experimentation and the amount of information they obtain.
A complete and up-to-date discussion of optimal split plot and split block designs Variations on Split Plot and Split Block Experiment Designs provides a comprehensive treatment of the design and analysis of two types of trials that are extremely popular in practice and play an integral part in the screening of applied experimental designs--split plot and split block experiments. Illustrated with numerous examples, this book presents a theoretical background and provides two and three error terms, a thorough review of the recent work in the area of split plot and split blocked experiments, and a number of significant results. Written by renowned specialists in the field, this book features: * Discussions of non-standard designs in addition to coverage of split block and split plot designs * Two chapters on combining split plot and split block designs and missing observations, which are unique to this book and to the field of study * SAS? commands spread throughout the book, which allow readers to bypass tedious computation and reveal startling observations * Detailed formulae and thorough remarks at the end of each chapter * Extensive data sets, which are posted on the book's FTP site The design and analysis approach advocated in Variations on Split Plot and Split Block Experiment Designs is essential in creating tailor-made experiments for applied statisticians from industry, medicine, agriculture, chemistry, and other fields of study.
Offering deep insight into the connections between design choice and the resulting statistical analysis, Design of Experiments: An Introduction Based on Linear Models explores how experiments are designed using the language of linear statistical models. The book presents an organized framework for understanding the statistical aspects of experiment
There is an increasing need to rein in the cost of scientific study without sacrificing accuracy in statistical inference. Optimal design is the judicious allocation of resources to achieve the objectives of studies using minimal cost via careful statistical planning. Researchers and practitioners in various fields of applied science are now beginning to recognize the advantages and potential of optimal experimental design. Applied Optimal Designs is the first book to catalogue the application of optimal design to real problems, documenting its widespread use across disciplines as diverse as drug development, education and ground water modelling. Includes contributions covering: Bayesian design for measuring cerebral blood-flow Optimal designs for biological models Computer adaptive testing Ground water modelling Epidemiological studies and pharmacological models Applied Optimal Designs bridges the gap between theory and practice, drawing together a selection of incisive articles from reputed collaborators. Broad in scope and inter-disciplinary in appeal, this book highlights the variety of opportunities available through the use of optimal design. The wide range of applications presented here should appeal to statisticians working with optimal designs, and to practitioners new to the theory and concepts involved.
Provides timely applications, modifications, and extensions of experimental designs for a variety of disciplines Design and Analysis of Experiments, Volume 3: Special Designs and Applications continues building upon the philosophical foundations of experimental design by providing important, modern applications of experimental design to the many fields that utilize them. The book also presents optimal and efficient designs for practice and covers key topics in current statistical research. Featuring contributions from leading researchers and academics, the book demonstrates how the presented concepts are used across various fields from genetics and medicinal and pharmaceutical research to manufacturing, engineering, and national security. Each chapter includes an introduction followed by the historical background as well as in-depth procedures that aid in the construction and analysis of the discussed designs. Topical coverage includes: Genetic cross experiments, microarray experiments, and variety trials Clinical trials, group-sequential designs, and adaptive designs Fractional factorial and search, choice, and optimal designs for generalized linear models Computer experiments with applications to homeland security Robust parameter designs and split-plot type response surface designs Analysis of directional data experiments Throughout the book, illustrative and numerical examples utilize SAS®, JMP®, and R software programs to demonstrate the discussed techniques. Related data sets and software applications are available on the book's related FTP site. Design and Analysis of Experiments, Volume 3 is an ideal textbook for graduate courses in experimental design and also serves as a practical, hands-on reference for statisticians and researchers across a wide array of subject areas, including biological sciences, engineering, medicine, and business.
Design of Experiments: A Modern Approach introduces readers to planning and conducting experiments, analyzing the resulting data, and obtaining valid and objective conclusions. This innovative textbook uses design optimization as its design construction approach, focusing on practical experiments in engineering, science, and business rather than orthogonal designs and extensive analysis. Requiring only first-course knowledge of statistics and familiarity with matrix algebra, student-friendly chapters cover the design process for a range of various types of experiments. The text follows a traditional outline for a design of experiments course, beginning with an introduction to the topic, historical notes, a review of fundamental statistics concepts, and a systematic process for designing and conducting experiments. Subsequent chapters cover simple comparative experiments, variance analysis, two-factor factorial experiments, randomized complete block design, response surface methodology, designs for nonlinear models, and more. Readers gain a solid understanding of the role of experimentation in technology commercialization and product realization activities—including new product design, manufacturing process development, and process improvement—as well as many applications of designed experiments in other areas such as marketing, service operations, e-commerce, and general business operations.
