The Influence of Prostaglandins and Other Agents on the Resorption and Synthesis of Mouse Calvarial Bone in Culture

The Influence of Prostaglandins and Other Agents on the Resorption and Synthesis of Mouse Calvarial Bone in Culture

Author: June Margaret Katz

Publisher:

Published: 1983

Total Pages: 416

ISBN-13:

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Calvaria dissected from 6-day-old mice were maintained in organ culture in a chemically-defined medium without serum additives. Bone resorption was quantified by the release of 45Ca or hydroxyproline (Hyp) into the medium. Collagen synthesis (Hyp) in bone was estimated by the incorporation of [5-3H]-proline. Prostaglandin E2 (PGE2), prostaglandin F (PGF) and 6-keto-prostaglandin F1a (6-keto-PGF1a) released into the medium from cultured calvaria, were measured by radioimmunoassay. Prostanoids were also quantified by the release of radioactively-labelled metabolites from calvaria pre-labelled in vitro with [3H]-arachidonic acid. These metabolites were separated by high performance liquid chromatography.


Prostaglandins In Bone Resorption

Prostaglandins In Bone Resorption

Author: Wilson Harvey

Publisher: CRC Press

Published: 2020-04-15

Total Pages: 176

ISBN-13: 1000696502

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First Published in 1988, this book offers a full, comprehensive guide into the process of bone resorption. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Osteology, and other practitioners in their respective fields.


Principles of Bone Biology

Principles of Bone Biology

Author: John P. Bilezikian

Publisher: Academic Press

Published: 2002-01-19

Total Pages: 1702

ISBN-13: 0080539602

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Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of boneProvides succinct coverage of the subjectContributors include over 200 of the most respected researchers in the fieldExtensive table of contents and index for easy referenceEasy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacologyComplete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996


The Kinin System

The Kinin System

Author: Stephen G. Farmer

Publisher: Academic Press

Published: 1997-04-01

Total Pages: 371

ISBN-13: 0080542522

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Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.


Connective Tissue and Its Heritable Disorders

Connective Tissue and Its Heritable Disorders

Author: Peter M. Royce

Publisher:

Published: 1993

Total Pages: 720

ISBN-13:

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Synthesizes a wealth of new information in the areas of biochemistry, genetics and molecular biology. Contains clear,well-organized material regarding advances in the study of heritable disorders of connective tissue, describing breakthroughs in the last ten years which, until now, have not been published.


Pathology Reviews · 1989

Pathology Reviews · 1989

Author: Emanuel Rubin

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 290

ISBN-13: 1461245028

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on the theories of Planck and Einstein. Rather, until The concept that human disease is a specialized branch of biology is universally accepted today, but in the mid-20th century, the accretion of individual historical perspective, is actually of recent origin. At examples of the biological nature of disease processes provided the framework for an evolutionary change in one time, the heliocentric theories of astronomy and the metallurgic transmutations of alchemy had their thinking. The new psychological and philosophical milieu provided the basis for an unprecedented accel counterparts in magical and vitalistic approaches to eration in the pace of biomedical research. It is clear human disease. Any relation between disease of humans and that of animals was not only unacceptable that the biological revolution of the last 35 years was made possible not only by technological advances and intellectually, but abhorrent theologically. Humans (and their diseases) were unique, and biology was the innovative analytical methods, but also by an intellec domain of those who studied animals and plants. tual emphasis on the unity of biological processes. The unification of biology and the study of human High school students are now aware that there is much disease, though begun some centuries ago, was con to be learned about the human condition by studying spicuously stimulated by the work of Darwin, and bacterial DNA, the chloroplasts of green leaves, or the reached its full flower in this century. For example, kinetics of enzymes in vitro.


Osteoporosis

Osteoporosis

Author: Robert Marcus

Publisher: Academic Press

Published: 2013-06-13

Total Pages: 2140

ISBN-13: 0123982529

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Now in its fourth edition, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine. Recognizes the critical importance of the Wnt signaling pathway for bone health Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone Examines essential updates on estrogen prevention and treatment and the recent results from the WHO Discusses the controversial topics of screening and clinical trial design for drug registration Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics