The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.
The instant New York Times bestseller The New York Times Best Selling author of The End of Alzheimer's lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower. In The End of Alzheimer's Dale Bredesen laid out the science behind his revolutionary new program that is the first to both prevent and reverse symptoms of Alzheimer's disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed, it can be tailored to anyone's needs and will enhance cognitive ability at any age. What we call Alzheimer's disease is actually a protective response to a wide variety of insults to the brain: inflammation, insulin resistance, toxins, infections, and inadequate levels of nutrients, hormones, and growth factors. Bredesen starts by having us figure out which of these insults we need to address and continues by laying out a personalized lifestyle plan. Focusing on the Ketoflex 12/3 Diet, which triggers ketosis and lets the brain restore itself with a minimum 12-hour fast, Dr. Bredesen drills down on restorative sleep, targeted supplementation, exercise, and brain training. He also examines the tricky question of toxic exposure and provides workarounds for many difficult problems. The takeaway is that we do not need to do the program perfectly but will see tremendous results if we can do it well enough. With inspiring stories from patients who have reversed cognitive decline and are now thriving, this book shifts the treatment paradigm and offers a new and effective way to enhance cognition as well as unprecedented hope to sufferers of this now no longer deadly disease.
The End of Alzheimer's: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer's outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer's disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer's outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer's, and will hopefully redirect many into new avenues of cellular research and discovery. - Comprehensive literature-based summary of the current state of molecular Alzheimer's disease research - Details the shortcomings of the prevailing model and therapeutics in development - Reviews blood-based biomarkers for Alzheimer's and their link to amyloid- and Tau-independent causes outside the brain - Describes the tissues outside the brain impacted by Alzheimer's and the underlying molecular causes - Explains the whole-body risks associated with Alzheimer's, along with concomitant measures to slow or prevent the disease - Provides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer's patients
The scientifically-proven practical plan to help reverse Alzheimer’s and prevent cognitive decline from the international bestselling author of The End of Alzheimer's. Following his ground-breaking book that transformed how we think about Alzheimer's and its treatment, world-renowned neurology expert Dale Bredesen provides an unprecedented hands-on guide to achieving complete brain health. In The End of Alzheimer's Programme, he lays out step-by-step his highly sought after, scientifically-proven method that you can follow with a healthcare professional to stop Alzheimer's in its tracks. Alzheimer’s Disease is a protective response to an array of factors that directly affect the brain, such as inflammation, genetic inheritance, nutrients and hormones. In this book, Bredesen will show you which of these factors you need to address to enhance your cognitive abilities by laying out a personalised lifestyle plan. Covering sleep, exercise, diet, brain training and more, Bredesen will show you how to retain, regain and maximise cognitive function for any ability and for any age with extraordinary results. Based on cutting-edge research and full of inspiring success stories from Bredesen’s patients, this book is a must-read for anyone looking to enhance their brainpower and is a vital guide for carers and healthcare professionals.
First person stories of patients who recovered from Alzheimer's Disease--and how they did it. It has been said that everyone knows a cancer survivor, but no one has met an Alzheimer's survivor - until now. In his first two books, Dr. Dale Bredesen outlined the revolutionary treatments that are changing what had previously seemed like the inevitable outcome of cognitive decline and dementia. And in these moving narratives, you can hear directly from the first survivors of Alzheimer's themselves--their own amazing stories of hope told in their own words. These first person accounts honestly detail the fear, struggle, and ultimate victory of each patient's journey. They vividly describe what it is like to have Alzheimer's. They also drill down on how each of these patients made the program work for them--the challenges, the workarounds, the encouraging results that are so motivating. Dr. Bredesen includes commentary following each story to help point readers to the tips and tricks that might help them as well. Dr. Bredesen's patients have not just survived; they have thrived to rediscover fulfilling lives, rewarding relationships, and meaningful work. This book will give unprecedented hope to patients and their families.
An illuminating biography of "the plague of the twenty-first century" and scientists' efforts to understand and, they hope, prevent it, The End of Memory is a book for those who want to find out the true story behind an affliction that courses through families and wreaks havoc on the lives of millions. It is a wicked disease that robs its victims of their memories, their ability to think clearly, and ultimately their lives. For centuries, those afflicted by Alzheimer's disease have suffered its debilitating effects while family members sit by, watching their loved ones disappear a little more each day until the person they used to know is gone forever. The disease was first described by German psychologist and neurologist Alois Alzheimer in 1906. One hundred years and a great deal of scientific effort later, much more is known about Alzheimer's, but it still affects millions around the world, and there is no cure in sight. In The End of Memory, award-winning science author Jay Ingram writes a biography of this disease that attacks the brains of patients. He charts the history of the disease from before it was noted by Alois Alzheimer through to the twenty-first century, explains the fascinating science of plaques and tangles, recounts the efforts to understand and combat the disease, and introduces us to the passionate researchers who are working to find a cure.
A revolutionary, proven program for reversing the symptoms of Alzheimer's disease and cognitive decline from award winning neurologists and codirectors of the Brain Health and Alzheimer's Prevention Program at Loma Linda University Medical Center Over 47 million people are currently living with Alzheimer’s disease worldwide. While all other major diseases are in decline, deaths from Alzheimer’s have increased radically. What you or your loved ones don’t yet know is that 90 percent of Alzheimer’s cases can be prevented. Based on the largest clinical and observational study to date, neurologists and codirectors of the Brain Health and Alzheimer’s Prevention Program at Loma Linda University Medical Center, Drs. Dean and Ayesha Sherzai, offer in The Alzheimer’s Solution the first comprehensive program for preventing Alzheimer’s disease and improving cognitive function. Alzheimer’s disease isn’t a genetic inevitability, and a diagnosis does not need to come with a death sentence. Ninety percent of grandparents, parents, husbands, and wives can be spared. Ninety percent of us can avoid ever getting Alzheimer’s, and for the 10 percent with strong genetic risk for cognitive decline, the disease can be delayed by ten to fifteen years. This isn’t an estimate or wishful thinking; it’s a percentage based on rigorous science and the remarkable results the Sherzais have seen firsthand in their clinic. This much-needed revolutionary book reveals how the brain is a living universe, directly influenced by nutrition, exercise, stress, sleep, and engagement. In other words: what you feed it, how you treat it, when you challenge it, and the ways in which you allow it to rest. These factors are the pillars of the groundbreaking program you’ll find in these pages, which features a personalized assessment for evaluating risk, a five-part program for prevention and symptom-reversal, and day-by-day guides for optimizing cognitive function. You can prevent Alzheimer’s disease from affecting you, your family, friends, and loved ones. Even with a diagnosis, you can reverse cognitive decline and add vibrant years to your life. The future of your brain is finally within your control.
A practical, helpful guide on how to fight back against Alzheimer’s disease—with expert medical advice and one woman’s inspiring personal journey. Jamie Tyrone was forty-nine years old when she learned by accident through genetic testing that she had a 91% chance of getting Alzheimer's disease. She was shocked, but after an initial bout with depression she decided to take action rather than concede defeat. Jamie teamed up with Dr. Marwan Sabbagh, a renowned neurologist, and together they created a resource detailing not just Jamie's experience, but expert medical advice for anyone facing the disease. This book is a practical, helpful guide for those who know they’re at greater risk of contracting Alzheimer’s disease. With cutting-edge medical guidance from Dr. Sabbagh about the true nature of Alzheimer’s, the risks involved, and daily steps you can take to protect yourself, Jamie’s story will encourage and empower you. In Fighting for My Life, readers will: Gain expert medical advice from Dr. Sabbagh on how to fight back against the disease Discover the pros, cons and possible dangers of genetic testing Witness a first-hand account of how to deal with the shadow of Alzheimer’s disease through Jamie’s story If Alzheimer’s has affected your life or the life of someone you know, this book is for you. You’ll be armed with information and ready to tackle Alzheimer’s head-on.
There is hope for sufferers of Alzheimer's disease and for those concerned about their future risk for the disease. The solution lies in the diagnosis, not in the treatments designated for the disease today. Alzheimer's is NOT a disease exclusively of the brain. A thorough broad and deep diagnosis of your entire health will often provide answers about the causes of Alzheimer's. With this knowledge in hand, you and your doctor may take measures to prevent, slow, stop, or reverse Alzheimer's and other forms of dementia. In "The End of Alzheimer's - A Differential Diagnosis Toward a Cure." Drs. Lewis and Trempe explore the disease and a proper diagnosis in detail. They describe the pitfalls and shortcoming of current medical research and clinical medicine. Most importantly they provide a simplified guide through a mountain of emerging science and medical information and explain what to obtain for a proper and comprehensive diagnosis, why there is hope for disease sufferers today, and forecast optimism for effective treatments in the future. They also include a 5-phase program to prevent Alzheimer's, diagnosis the disease in asymptomatic people, find route causes of the disease, and offer disease management and treatment advice. Here is what experts are saying about "The End of Alzheimer's?" Dr. Alzheimer, for whom Alzheimer's disease is named, would be totally perplexed and disheartened at the fact that after a century of research and over 100,000 scientific and medical papers written on the subject, patients presently diagnosed with Alzheimer's disease are no better off now than they were in 1907, when he diagnosed the first Alzheimer's case. This fact alone invites the troubling question, are we on the right track to finding a way to help Alzheimer patients? To search for an answer to this consequential question, one needs to read "The End of Alzheimer's?" by Dr. Thomas Lewis and Dr. Clement Trempe who write about this disquieting problem and possible ways to solve it. Drs. Lewis and Trempe have written a mind-opening, well-informed and intelligent account of the history, present and future interventions, and distillation of keen thinking on the subject of Alzheimer's disease. This book will be the focus of many prospective and pivotal discussions on how medical research will eventually govern this mind-shattering disorder. Jack C. de la Torre, MD, PhD, Professor of Psychology, University of Texas, Austin Austin, Texas 79712, Senior Editor, Journal of Alzheimer's Disease The brilliant strategy by Drs. Lewis and Trempe takes advantage of revolutionary new concepts for guiding enhancement of immune function and treatment of chronic infections in prevention and treatment of Alzheimer's disease. The diagnosis of mild cognitive impairment by psychological testing, combined with assessment of ophthalmological abnormalities and determination of health status through thorough testing of biochemical markers related to infection and inflammation, are necessary for improving the prognosis and reducing the risk of dementia. The implications of this strategy for the individual and for the population are enormous. Control of dementia, atherosclerosis, and degenerative diseases of aging by the insights of Drs. Lewis and Trempe has the potential for revolutionizing management of chronic disease in the general population. Kilmer S. McCully, MD, Chief of Pathology and Laboratory Medicine, United States Department of Veterans Affairs Medical Center, VA Boston Healthcare System, Boston, MA 02132. Pioneer of the Homocysteine Theory.
A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.
