The Efficacy of Using Drosophila Melanogaster as a Model Organism for the Study of Parkinson's Disease at the Behavioral, Cellular, and Genetic Level
Author: Anthony Mell
Publisher:
Published: 2013
Total Pages: 76
ISBN-13:
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Author: Anthony Mell
Publisher:
Published: 2013
Total Pages: 76
ISBN-13:
DOWNLOAD EBOOKAuthor: Kinga Maria Michno
Publisher:
Published: 2009
Total Pages:
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DOWNLOAD EBOOKAuthor: Graziella Madeo
Publisher: Frontiers Media SA
Published: 2019-11-26
Total Pages: 144
ISBN-13: 2889631893
DOWNLOAD EBOOKAuthor: Amritpal Mudher
Publisher: Taylor & Francis
Published: 2020-11-25
Total Pages: 233
ISBN-13: 1000115534
DOWNLOAD EBOOKDrosophila gives an overview of the ways in which Drosophila is currently being used as a model organism to further our understanding of a spectrum of human neurological diseases. Each chapter is written by respected researchers and gives an excellent account of the subject that is suitable for postgraduate and postdoctoral researchers.
Author: Vitaly Koltover
Publisher: Academic Press
Published: 2022-12-07
Total Pages: 400
ISBN-13: 0128236809
DOWNLOAD EBOOKAnti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice. Includes updated information about current developments in anti-aging pharmacology Offers practical advice on the applicability of certain healthspan-promoting medications Discusses potential challenges related to the translation of anti-aging drugs in clinical practice
Author: Josh Dubnau
Publisher: Cambridge University Press
Published: 2014-06-26
Total Pages: 309
ISBN-13: 1107009030
DOWNLOAD EBOOKA comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Author: Farzana Khan Perveen
Publisher: BoD – Books on Demand
Published: 2018-02-28
Total Pages: 270
ISBN-13: 9535138537
DOWNLOAD EBOOKThis book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Author: Masamitsu Yamaguchi
Publisher: Springer
Published: 2018-06-27
Total Pages: 314
ISBN-13: 9811305293
DOWNLOAD EBOOKMost biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Author:
Publisher: Academic Press
Published: 2021-03-28
Total Pages: 244
ISBN-13: 0323853226
DOWNLOAD EBOOKReprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics. Offers a basic understanding and clear picture of genome editing CRISPR-Cas systems in different organisms Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for removal of virus, bacteria, fungi, protozoan, and many more Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, and many more
Author: David R. Riddle
Publisher: CRC Press
Published: 2007-04-19
Total Pages: 408
ISBN-13: 9781420005523
DOWNLOAD EBOOKRecognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur