Developmental Aspects of the Lymphatic Vascular System
Developmental Aspects of the Lymphatic Vascular System

Author: Friedemann Kiefer

Publisher: Springer Science & Business Media

Published: 2013-11-26

Total Pages: 212

ISBN-13: 3709116465

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The book focuses on the lymphatic vascular system from a developmental biologist’s point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.

The Development of the Lymphatic System in Man
The Development of the Lymphatic System in Man

Author: S.C.J. van der Putte

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 60

ISBN-13: 3642660908

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When Budge in the eighth decade of the nineteenth centlll'Y, started his investigations into the origin and development of the lymphatic system, he probably did not expect that these would be the starting-point for disputes that would continue well into our time. But rather than by his results were these disputes intensified by the controversial conclusions of some papers published by Gulland (1894), Ranvier (1897) and Sala (1900), and above all by some new investigations by Sabin (1902-1913) and Huntington (1908-1914) during the first decades of the twentieth century. The most important controversial point was the difference in opinion about the origin of the lymphatic system. An extensive review of the relevant literature is found in O. F. Kampmeier's book: "Evolution and Comparative Morphology of the Lymphatic System"; Thomas, Springfield, U.S.A. (1969). Whereas some investigators were of the opinion that the lymphatic system was formed from the venous system, there were many others, who believed that this system originates from confluent spaces in the mesenchyme and secondarily communicates with the veins. The most prominent advocate of the first mentioned opinion was Sabin (1902-1913). She believed that the lymphatics are formed by a process of sprouting from the large central veins in a limited number of definitely localized areas, but that these sprouts demonstrate almost immediately their own lymphatic character. From these sprouts separate primordia develop at first; these enlarge, confluence and form new sprouts which grow out into more peripheral parts of the embryo.

Lymphatic Structure and Function in Health and Disease
Lymphatic Structure and Function in Health and Disease

Author: Felicity N.E. Gavins

Publisher: Academic Press

Published: 2019-10-23

Total Pages: 180

ISBN-13: 0128156465

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Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction. Brings together lymphatic medicine as a whole, with an in-depth analysis of the specific basic science aspects of lymphatic structure and function Covers the clinical aspects of lymphatics in different vascular pathologies Co-published with the International Society of Neurovascular Diseases Discusses lymphatic structure and function in all of the major organ systems

The Lymphatic System in Health and Disease
The Lymphatic System in Health and Disease

Author: J. Winny Yun

Publisher: Biota Publishing

Published: 2018-11-09

Total Pages: 106

ISBN-13: 1615047921

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The lymphatic system develops and functions in parallel with the blood circulatory system (termed the "hemovasculature") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar. This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.

Angiogenesis Assays
Angiogenesis Assays

Author: Carolyn A. Staton

Publisher: John Wiley & Sons

Published: 2007-01-11

Total Pages: 410

ISBN-13: 047002934X

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Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

The American Journal of Anatomy
The American Journal of Anatomy

Author:

Publisher:

Published: 1917

Total Pages: 1056

ISBN-13:

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Volumes 1-5 include Proceedings of the Association of American anatomists (later American Association of Anatomists), 15th-20th session (Dec. 1901/Jan. 1902-Dec. 1905).