The Catecholamines in Psychiatric and Neurologic Disorders

The Catecholamines in Psychiatric and Neurologic Disorders

Author: C. Raymond Lake

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 366

ISBN-13: 1483163121

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The Catecholamines in Psychiatric and Neurologic Disorders focuses on the contributions of catecholamines (CA) in the modulation of blood pressure, stress and exercise, body movements, memory, learning, emotions, thought processing, appetite, and mediation of psychotropic drug action. The selection first elaborates on the techniques for the assessment and interpretation of catecholamine measurements in neuropsychiatric patients and catecholaminergic response to stress and exercise. Discussions focus on noradrenergic response to isometric exercise, isotonic exercise, effect of acceleration on sympathetic activity, techniques for sympathetic nervous system evaluation, and measurements of CA and their metabolites in cerebrospinal fluid. The text then takes a look at urinary CA in behavioral research on stress; CA in anxiety disorders and mitral valve prolapse; and interaction with neurotransmitters in normal subjects and in patients with selected neurologic diseases. The selection examines noradrenergic responses in postural hypotension, norepinephrine, alcohol, and alcoholism, and catecholamine metabolism in anorexia nervosa. Topics include cerebral catecholamine metabolism in anorexia nervosa; central nervous system norepinephrine and voluntary alcohol drinking; and overview of norepinephrine in selected pediatric disorders. The book is a dependable reference for neuropsychiatrists and readers interested in the contributions of catecholamines on psychiatric disorders.


Magnesium in the Central Nervous System

Magnesium in the Central Nervous System

Author: Robert Vink

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 354

ISBN-13: 0987073052

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The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.


The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide

Author: Yogesh Dwivedi

Publisher: CRC Press

Published: 2012-06-25

Total Pages: 485

ISBN-13: 143983881X

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With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.


Stress and Mental Disorders

Stress and Mental Disorders

Author: Richard McCarty

Publisher: Oxford University Press, USA

Published: 2020

Total Pages: 673

ISBN-13: 0190697261

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Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.


Essential Clinical Anesthesia

Essential Clinical Anesthesia

Author: Charles Vacanti

Publisher: Cambridge University Press

Published: 2011-07-11

Total Pages: 1191

ISBN-13: 1139498401

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The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.


Endocrine Hypertension

Endocrine Hypertension

Author: Karel Pacak

Publisher:

Published: 2002

Total Pages: 0

ISBN-13: 9781573314183

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Several genetic, biochemical and radiologic discoveries have impacted the management of endocrine hypertension, while surgical procedures have revolutionized treatment of patients with endocrine hypertension. This text contains the proceedings of a 2001 workshop on the topic.


Orthogeriatrics

Orthogeriatrics

Author: Paolo Falaschi

Publisher: Springer Nature

Published: 2021

Total Pages: 355

ISBN-13: 3030481263

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This new open access edition supported by the Fragility Fracture Network aims at giving the widest possible dissemination on fragility fracture (especially hip fracture) management and notably in countries where this expertise is sorely needed. It has been extensively revised and updated by the experts of this network to provide a unique and reliable content in one single volume. Throughout the book, attention is given to the difficult question of how to provide best practice in countries where the discipline of geriatric medicine is not well established and resources for secondary prevention are scarce. The revised and updated chapters on the epidemiology of hip fractures, osteoporosis, sarcopenia, surgery, anaesthesia, medical management of frailty, peri-operative complications, rehabilitation and nursing are supplemented by six new chapters. These include an overview of the multidisciplinary approach to fragility fractures and new contributions on pre-hospital care, treatment in the emergency room, falls prevention, nutrition and systems for audit. The reader will have an exhaustive overview and will gain essential, practical knowledge on how best to manage fractures in elderly patients and how to develop clinical systems that do so reliably.


Psychosomatic Medicine

Psychosomatic Medicine

Author: Kurt Ackerman

Publisher: Oxford University Press, USA

Published: 2015

Total Pages: 489

ISBN-13: 0199329311

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Psychosomatic Medicine (PM) is a rapidly developing subspecialty of psychiatry focusing on psychiatric care of patients with other medical disorders. PM practitioners strive to stay current with the latest research and practice guidelines in a burgeoning field involving complex interactions and combinations of illnesses. To address these challenges, this book provides practical instruction from PM clinicians, educators and researchers, covering core clinical concepts routinely used in practice.


Obsessive-compulsive Disorder

Obsessive-compulsive Disorder

Author: Christopher Pittenger

Publisher: Oxford University Press

Published: 2017

Total Pages: 777

ISBN-13: 0190228164

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Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications.