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The Biochemistry of the Nucleic Acids

Author: R.L.P. Adams

Publisher: Springer Science & Business Media

Published: 2013-04-18

Total Pages: 689

ISBN-13: 9401122903

When the first edition of this book was published in 1950, it predated the publication of the double-helical structure of DNA by three years. It is not, therefore, surprizing that nothing of the original book remains in the current edition. Indeed, such is the pace of change in the field of nucleic acids that less than 50% of material incorporated into the 1986 edition has been retained. The book aims at the advanced undergraduate and at graduates that are undertaking course work or requiring an in-depth background for their research. It also aims to provide the established scientist with a single text that permits updating across the whole field from DNA structure, replication and repair, through gene expression and its control to protein synthesis. Every chapter is accompanied by thorough referencing that enables the reader to evaluate personally the data and methodology that cannot be included in the text. In an attempt to keep this list within bounds, references are limited to about ten per page and, to accommodate the more recent literature, many of the older references have been left out in this latest edition.

The Biochemistry of the Nucleic Acids

Author: R. L. Adams

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 542

ISBN-13: 940094103X

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When the first edition of this book was published in 1950, it set out to present an elementary outline of the state of knowledge of nucleic acid biochemistry at that time and it was the first monograph on the subject to appear since Levene's book on Nucleic Acids in 1931. The fact that a tenth edition is required after thirty five years and that virtually nothing of the original book has been retained is some measure of the speed with which knowledge has advanced in this field. As a result of this vast increase in information it becomes increasingly difficult to fulfil the aims of providing an introduction to nucleic acid biochemistry and satisfying the requirements of advanced undergraduates and postgraduates in biochemistry, genetics and molecular biology. We have attempted to achieve these aims by con centrating on those basic aspects not normally covered in the general biochemistry textbooks and by providing copious references so that details of methodology can readily be retrieved by those requiring further information. The first seven editions emerged from the pen of J. N. Davidson who died in September 1972 shortly after completing the seventh edition. The subsequent editions have been produced by various colleagues who have tried to retain something of the character and structure of the earlier editions while at the same time introducing new ideas and concepts and eliminating some of the more out -dated material.

Nucleic Acids in Chemistry and Biology

Author: G Michael Blackburn

Publisher: Royal Society of Chemistry

Published: 2015-11-09

Total Pages: 503

ISBN-13: 1782625771

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The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Nucleic Acids

Author: Victor A. Bloomfield

Publisher: Sterling Publishing Company

Published: 2000-04-17

Total Pages: 854

ISBN-13: 9780935702491

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Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text has been organized to meet the needs of those who have only a basic understanding of physical chemistry and molecular biology.

The biochemistry of the Nucleic Acids

Author: J.N. Davidson

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 415

ISBN-13: 0323151590

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The Biochemistry of the Nucleic Acids provides an elementary outline of the main biochemical features of nucleic acids and nucleoproteins. The book describes the occurrence and biological functions of nucleic acids, their chemical constituents, and catabolism. This text is organized into 14 chapters and begins with a historical overview, from the discovery of the nucleic acids to their isolation and characterization. The discussion then shifts to bacterial transforming factors and transduction phenomena, along with the genetic function and metabolic stability of DNA, the chemical composition of the cell nucleus, and the Feulgen nucleal reaction. The reader is methodically introduced to the structure and biosynthesis of RNA and DNA; nucleic acids found in viruses; and biosynthesis of mononucleotides. An account of nucleases and related enzymes is also given. A chapter on the precise mechanism by which nucleic acids are broken down in the cell concludes the book. This book is intended for students of biochemistry, chemists, and biologists.

The Chemical Biology of Nucleic Acids

Author: Günter Mayer

Publisher: John Wiley & Sons

Published: 2011-06-17

Total Pages: 595

ISBN-13: 1119957265

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With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Chemistry of Nucleic Acids

Author: Harri Lönnberg

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2024-09-23

Total Pages: 553

ISBN-13: 311132592X

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Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function.

Nucleic Acids in Chemistry and Biology

Author: G. Michael Blackburn

Publisher: Irl Press

Published: 1996

Total Pages: 528

ISBN-13: 9780199635337

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Since the discovery of the DNA double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Nowhere is this more apparent than in the increasing efforts to determine the DNA sequence of the human genome and the development of new diagnostics of genetic disease. Recent sophistication of nucleic acids synthesis has been key to the establishment of the biotechnology industry and our improving knowledge of nucleic acid structures and interactions is noticeably influencing the design of novel drugs.This second and completely revised edition draws on the expertise of the same international group of authors to set the basics of the nucleic acids in the context of the expanding horizons set by modern structural biology, RNA enzymology, drug discovery and biotechnology.